Engineering of ovarian tissue for ovarian dysfunctions: A review by Aliya Zhylkybekova, Gulbakit K. Koshmaganbetova, Myltykbay S. Rysmakhanov, Nurgul Abdullayevna Abenova, Nadiar Maratovich Mussin, Asset Askerovich Kaliyev, Mahdi Mahdipour, Amin Tamadon

“…Both approaches show promise in preclinical studies for creating functional ovarian tissue. …”
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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…Natural health products such as papaya leaf extract and dandelion root extract have been shown to demonstrate anticancer activity in preclinical and clinical studies, respectively. We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.…”
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Tofersen and other antisense oligonucleotides in ALS by Albert Ludolph, Maximilian Wiesenfarth

“…The results of treatment with the ASO tofersen in SOD1-ALS show that the drug has a convincing beneficial effect on ALS caused by SOD1 mutations, that preclinical studies in rodents predicted the therapeutic effect in the human disease, and that clinical efficacy is associated with a specific sequence of effects of the drug on mechanistic and degenerative biomarkers and, subsequently, functional outcomes such as weight stabilization and ALSFRS-R. …”
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Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer by Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang

“…In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. …”
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Reduction of Image Artifacts in Mice by Bladder Flushing with a Novel Double-Lumen Urethral Catheter by Chad R. Haney, Adrian D. Parasca, Kazuhiro Ichikawa, Benjamin B. Williams, Martyna Elas, Charles A. Pelizzari, Howard J. Halpern

“…Mouse model images have become increasingly important in preclinical testing. To minimize bladder accumulation on mouse images, we developed a novel, minimally invasive, MRI/EPRI-friendly procedure for flushing a female mouse bladder. …”
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“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. …”
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Cannabinoids: A New Group of Agonists of PPARs by Yan Sun, Andy Bennett

“…This demands that these new compounds be free of the psychotropic effects that connected with the recreational use of cannabinoids. In preclinical studies cannabinoids displayed many of the characteristics of nonsteroidal anti-inflammatory drugs (NSAIDs) and it seems to be free of unwanted side effects. …”
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CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity by Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen

“…Besides, CAR-based cell therapy have extended its reach beyond oncology to autoimmune disorders. We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. …”
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Immune links in comorbid depression and psoriasis: A narrative mini-review and perspective by Georgia Lada

“…Despite an early interest in the brain-skin axis and the role of stress in psoriasis immunopathogenesis, there is ongoing limited preclinical and clinical research into the inflammatory links between depression and psoriasis. …”
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Interleukin 2-Based Fusion Proteins for the Treatment of Cancer by Alana MacDonald, T.-C. Wu, Chien-Fu Hung

“…The ability of IL-2 to mediate tumor regression in preclinical and clinical settings led to FDA approval for its use in the treatment of metastatic renal cell carcinoma and metastatic melanoma in the 1990s. …”
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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We developed a novel “two-hit” model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical features of HFpEF. …”
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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer by Lukas Klein, Mengyu Tu, Niklas Krebs, Laura Urbach, Daniela Grimm, Muhammad Umair Latif, Frederike Penz, Anna Blandau, Xueyan Wu, Rebecca Diya Samuel, Stefan Küffer, Florian Wegwitz, Nathan Chan, Kazeera Aliar, Foram Vyas, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Elisa Espinet, Argyris Papantonis, Rama Khokha, Volker Ellenrieder, Barbara T. Grünwald, Shiv K. Singh

“…Consequently, combined preclinical anti-TNF-α immunotherapy and chemotherapy reduces macrophages and promotes CD3+/CD8+ T cell infiltration in basal-like PDAC, improving survival. …”
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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

“…However, to date there are few preclinical models that accurately represent these disparate disease scenarios.Methods Using combinatorial radio-immunotherapy consisting of PD-1 blockade, IL2Rβγ biased signaling, and OX40 agonism we were able to generate preclinical tumor models with conflicting responses, where head and neck squamous cell carcinoma (HNSCC) models respond and pancreatic ductal adenocarcinoma (PDAC) progresses.Results By modeling these disparate states, we find that regulatory T cells (Tregs) are expanded in PDAC tumors undergoing treatment, constraining tumor reactive CD8 T cell activity. …”
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Assessment of Convergence Angle of Tooth Preparations for Complete Crowns Among Dental Students: Typodont vs Simulator by Meriem Amine, Hafsa Oumayma Wahid, Saliha Fahi, Safaa Lehmouddi, Mouna Hamza, Samira Elarabi

“…Are students able to reproduce, in preclinical, total occlusal convergence (TOC) angles recommended on typodont and simulator? …”
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Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes by Loredana Bucciarelli, Daniele Andreini, Giulio Stefanini, Roberta Maria Fiorina, Marco Francone, Federica Catapano, Maria Elena Lunati, Edoardo Conte, Davide Marchetti, Paolo Fiorina

“…In this review, we are revisiting the existence of atherosclerosis regression in preclinical and clinical studies, with a focus on the latest mechanistic insights and on the newest pharmacological agents, particularly in patients with diabetes. …”
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Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development by Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar-Regenscheit

“…Recent advancements in engineering Complex in vitro models (CIVMs) such as Blood-brain barrier (BBB) organoids offer promising platforms for preclinical drug testing. However, their application in drug development, and especially for the regulatory purposes of toxicity assessment, requires robust and reproducible techniques. …”
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S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines by Yong-Sik Bong, David Brown, Ezra Chung, Neeti Ananthaswamy, Renxiang Chen, Renxiang Chen, Evan Lewoczko, William Sabbers, Athéna C. Patterson-Orazem, Zachary Dorsey, Yiqing Zou, Xue Yu, Jiening Liang, Jiaxi He, Steven Long, Dong Shen

“…The vaccine’s immunogenicity and protective efficacy were evaluated in preclinical models, including monovalent (RV-1730) and bivalent (RV-1731) formulations targeting the Delta and BA.1 variants. …”
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Positron Emission Tomographic Imaging of the Cannabinoid Type 1 Receptor System with [C]OMAR ([C]JHU75528): Improvements in Image Quantification Using Wild-Type and Knockout Mice by Raúl Herance, Santiago Rojas, Sergio Abad, Xavier Jiménez, Juan Domingo Gispert, Olga Millán, Elena Martín-García, Aurelijus Burokas, Miquel Àngel Serra, Rafael Maldonado, Deborah Pareto

“…In addition, this methodology can be used to assess the effect of new drugs in preclinical studies using genetically manipulated animals.…”
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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

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