Glutamate Receptors in Neuroinflammatory Demyelinating Disease

“…The search for new MS treatments invariably employs EAE to determine drug activity and provide a rationale for exploring clinical efficacy. The preclinical development of compounds for MS has generally followed a conventional, immunotherapeutic route. …”
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New Antibody Conjugates in Cancer Therapy by Serengulam V. Govindan, David M. Goldenberg

“…The advantage of pretargeted RAIT over directly labeled MAbs is continuing to be validated in preclinical models of lymphoma and solid tumors. Importantly, the advantages of combining RAIT with radiation sensitizers, with immunotherapy, or a drug conjugate targeting a different antigen are being studied clinically and preclinically. …”
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Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities by Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan

“…We also discussed the recent update on small-molecule inhibitors and PROTACs and their progress in preclinical and clinical trials.…”
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Stem Cell Applications in Tendon Disorders: A Clinical Perspective by Mark Young

“…However, tendons usually heal with fibrosis and scar tissue, which has suboptimal tensile strength and is prone to reinjury, resulting in lifestyle changes with activity restriction. Preclinical studies show that cell therapies have the potential to regenerate rather than repair tendon tissue, a process termed tenogenesis. …”
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Stem Cell Tracking with Nanoparticles for Regenerative Medicine Purposes: An Overview by Lisa Accomasso, Clara Gallina, Valentina Turinetto, Claudia Giachino

“…Moreover, this review has summarized the advantages and applications of stem cell tracking with nanoparticles in experimental and preclinical studies and investigated present limitations for their employment in the clinical setting.…”
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…Furthermore, encouraging preclinical data has necessitated the progression of a few of these drugs into clinical trials in order to make the most effective use of interventions in the development of viable targeted therapeutics. …”
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Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges by Ling He, Qianrong Li

“…This review discusses the use of various biomaterials in MSC-based therapies for endometrial reconstruction and summarizes evidence from preclinical and clinical studies, highlighting the efficacy and safety of these biomaterials. …”
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A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community by Nancy Bonareri Mitaki, Ilemobayo Victor Fasogbon, Onyinye Vivian Ojiakor, Wusa Makena, Emmanuel O. Ikuomola, Reuben Samson Dangana, Ibe Micheal Usman, Ekom Monday Etukudo, Augustine Oviosun, Swase Dominic Terkimbi, Elizabeth Bessy Umoren, Angela Mumbua Musyoka, Solomon A Mbina, Esther Ugo Alum, Ibrahim Babangida Abubakar, Godson Emeka Anyanwu, Patrick Maduabuchi Aja

“…We limited our search to peer-reviewed English articles, preclinical models, and intervention studies reporting the use of medicinal plants in the treatment of diabetes, particularly in EAC. …”
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Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review by Laya Jalilian-Khave, Razi Kitaneh, Binah Baht Ysrayl, Anna Borelli, Melissa C. Funaro, Marc N. Potenza, Gustavo A. Angarita

“…This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. …”
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Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…This review explores the different phases of in vitro and preclinical ASC characterisation and describes the development of appropriate potency assays. …”
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Cytokine landscapes of pregnancy: mapping gestational immune phases by Sulagna Dutta, Pallav Sengupta, Fong Fong Liew

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Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71 by Rosalba Parenti, Lucia Salvatorelli, Gaetano Magro

“…This review briefly focuses on main molecular events that characterize ATC and provides an update about preclinical studies. In addition, the overexpression of transferrin receptor 1 (TfR1/CD71) by neoplastic cells of ATC is emphasized in that it could represent a potential therapeutic target. …”
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EVALUATION OF THE THERAPEUTIC EFFECTS OF SALVIA ROSMARINUS ESSENTIAL OIL ON NERVOUS SYSTEM DISORDERS by Malina Mihaela Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica

“…This review explores the therapeutic potential of rosemary in alleviating nervous system disorders such as Alzheimer's disease (AD), major depressive disorder (MDD), epilepsy, Parkinson's disease (PD), addiction, and attention-deficit hyperactivity disorder (ADHD). Preclinical and clinical research suggests that rosemary extracts, through their active compounds, may enhance cognitive function, protect neurons from oxidative stress, and modulate neurotransmitters involved in cognitive and emotional processes. …”
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Gelatin-based biomaterials as a delivery strategy for osteosarcoma treatment by Qifan Yang, Xingpeng Chen, Jing Liu, Yeteng He

“…At present, gelatin-based hydrogels, gelatin scaffolds, and gelatin-based nanoparticles have been reported in preclinical studies. In this article, we introduce the application of gelatin-based biomaterials in the treatment of osteosarcoma, and summarize and look forward to them.…”
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Information and communication technologies' knowledge and use by Health Technology teachers by Rafaela Nayibe Curi Mendoza

“…The studied population was the Department of Health Technology's professors of the Victoria de Girón  Basic and Preclinical Sciences Institute  in 2021. Summary measures were used for the variables according to their nature.…”
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Intratumor heterogeneity in KRAS signaling shapes treatment resistance by Oleksi Petrenko, Varvara Kirillov, Stephen D'Amico, Nancy C. Reich

“…Combination immunotherapy leads to durable tumor regression in preclinical models.…”
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EGFR Amplification and Glioblastoma Stem-Like Cells by Katrin Liffers, Katrin Lamszus, Alexander Schulte

“…GS-cells with retained EGFR amplification could overcome the limitations of current in vitro model systems and contribute significantly to preclinical research on EGFR-targeted therapy. This review recapitulates recent methodological approaches to expand stem-like cells from GBM with different EGFR status in order to maintain EGFR-dependent intratumoral heterogeneity in vitro. …”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…In this review, we summarize and discuss promising immunotherapies for GBM currently under preclinical investigation as well as in clinical trials.…”
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New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway by Xiao Hua Pan, Jianxin Zhang, Xiaowei Yu, Ling Qin, Ligeng Kang, Peng Zhang

“…Therefore, new therapeutic approaches may rise from these two newly discovered pathways. More preclinical experiments and clinical trials are required to confirm our viewpoint.…”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Based on these abovementioned approaches, we aimed to comprehensively analyze various preclinical and clinical studies from traditional to regenerative therapeutic approaches in managing concomitant NAFLD and T2DM.…”
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