Bacteria in Cancer Therapy: Renaissance of an Old Concept by Sebastian Felgner, Dino Kocijancic, Michael Frahm, Siegfried Weiss

“…This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. …”
Get full text

Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias by Hagai Yavin, Mark Prasad, Jonathan Gordon, Tolga Aksu, Henry D. Huang

“…In this review, we discuss the available preclinical and clinical evidence for PFA for atrial fibrillation, developments for ventricular arrhythmia (VA) ablation, and future perspectives.…”
Get full text

Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…The results from recent preclinical studies regarding stem cell-based therapies are promising. …”
Get full text

Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco by Soufiane Drioua, Abha Cherkani-Hassani, Otman El-Guourrami, Mouna Ameggouz, Ahmed Zahidi, Abdelhakim Bouyahaya, Sayyed Ibrahim Shah, Yaser Mohammed Al-Worafi, Long Chiau Ming, Hanane Benzaied, Anass Doukkali

“…Further research, including preclinical and clinical trials, should be conducted to investigate the potential therapeutic benefits of these plants. …”
Get full text

Advances in the Use of Stem Cells in Veterinary Medicine: From Basic Research to Clinical Practice by Melissa Medeiros Markoski

“…Knowledge about how adult stem cells modulate the molecular signals to activate cell homing has also been increasingly determined, evidencing the mechanisms which enable cells to repair and regenerate injured tissues. Preclinical studies were designed for many animal models and they have contributed to the translation to the human clinic. …”
Get full text

Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease by Allison P. Watson, Claudio G. Brunstein, Shernan G. Holtan

“…Ruxolitinib is an oral selective Janus-associated kinase 1 (JAK1) and JAK2 inhibitor that was initially approved by the FDA in 2014 for treatment of myelofibrosis. In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD. …”
Get full text

CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms by Raanan Greenman, Chris J. Weston

“…This review delves into the intricate role of CCL24 in fibrotic diseases, highlighting its impact on fibrotic, immune, and vascular pathways. We focus on the preclinical and clinical evidence supporting the therapeutic potential of blocking CCL24 in diseases that involve excessive inflammation and fibrosis.…”
Get full text

The role of high-density lipoproteins in sepsis by Liam R. Brunham

“…In epidemiological studies, low levels of HDL cholesterol are strongly associated with risk of infectious diseases and death from sepsis and, during sepsis, a larger decline in HDL cholesterol predicts a worse outcome. Many preclinical studies have examined strategies to augment HDL genetically or pharmacologically and have shown that this leads to protection from sepsis in animal models. …”
Get full text

Regulatory T Cells in Allogeneic Stem Cell Transplantation by Maria Michael, Avichai Shimoni, Arnon Nagler

“…Over the last decade, a large body of evidence from preclinical models has demonstrated their crucial role in auto- and tumor immunity and has opened the door to their “first-in-man” clinical application. …”
Get full text

Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping by Shunsuke Ohnishi, Stephen J. Lomnes, Rita G. Laurence, Andrew Gogbashian, Giuliano Mariani, John V. Frangioni

“…One contrast agent, NIR fluorescent human serum albumin (HSA800), emerged as the molecule with the best overall performance with respect to entry to lymphatics, flow to the SLN, retention in the SLN, fluorescence yield and reproducibility. This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies.…”
Get full text

A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome by Clara Gallina, Valentina Turinetto, Claudia Giachino

“…Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in humans. …”
Get full text

The Role of CARD9 Deficiency in Neutrophils by Ruanmei Sheng, Xiaoming Zhong, Zhiwen Yang, Xuemin Wang

“…Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.…”
Get full text

Leukocyte Adhesion Molecules in Diabetic Retinopathy by Kousuke Noda, Shintaro Nakao, Susumu Ishida, Tatsuro Ishibashi

“…This paper summarizes the recent clinical and preclinical works on the roles of leukocyte adhesion molecules in DR.…”
Get full text

Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

“…The role of the vagal nerves in activation of various immune responses through preclinical and clinical evidence has established its role in assisting the control of inflammation and improving survival in the infectious and inflammatory disorders through efferent as well as afferent vagal pathways that regulate the peripheral inflammation via the central nervous system. …”
Get full text

Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer by Andrea L. A. Wong, Soo-Chin Lee

“…This paper summarizes existing preclinical and clinical evidence on the mechanisms of trastuzumab action and resistance and provides an up-to-date overview of novel HER2-directed therapies in clinical development.…”
Get full text

Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…This comprehensive review article specifically examines classical unconjugated and toxin-conjugated monoclonal antibodies, which are currently in the preclinical phase or undergoing evaluation in clinical trials. …”
Get full text

Is platelet activating factor (PAF) an important mediator in bronchial asthma? by R. H. Gundel, H. O. Heuer, L. G. Letts

“…The development of selective PAF receptor antagonists may provide a novel approach to the treatment of human bronchial asthma. In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. …”
Get full text

Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus by Muhammad U. Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E. Marei

“…Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.…”
Get full text

In Vivo Molecular Imaging in Retinal Disease by Fang Xie, Wenting Luo, Zhongyu Zhang, Dawei Sun

“…In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current preclinical findings and advances in instrumentation such as endoscopes and microcatheters suggest that these molecular imaging modalities have numerous clinical applications and will be translated into clinical use in the near future.…”
Get full text

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity by Urszula Doboszewska, Piotr Wlaź, Gabriel Nowak, Maria Radziwoń-Zaleska, Ranji Cui, Katarzyna Młyniec

“…Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. …”
Get full text