The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells by Tao Du, Ying-Jian Zhu

“…Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. Various preclinical studies indicated the beneficial effects of MSCs in alleviating renal injury and accelerating tissue repair. …”
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Twenty-year review of author characteristics and academic articles published in a medical student journal by Lorna Pairman, Angad S Chauhan

“…There was a decline in the proportion of articles authored by preclinical students (from 25% to 6%) and with University of Otago affiliation (from (59% to 28%) when comparing the first and second decades of NZMSJ publication. …”
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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…Natural health products such as papaya leaf extract and dandelion root extract have been shown to demonstrate anticancer activity in preclinical and clinical studies, respectively. We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.…”
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Tofersen and other antisense oligonucleotides in ALS by Albert Ludolph, Maximilian Wiesenfarth

“…The results of treatment with the ASO tofersen in SOD1-ALS show that the drug has a convincing beneficial effect on ALS caused by SOD1 mutations, that preclinical studies in rodents predicted the therapeutic effect in the human disease, and that clinical efficacy is associated with a specific sequence of effects of the drug on mechanistic and degenerative biomarkers and, subsequently, functional outcomes such as weight stabilization and ALSFRS-R. …”
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Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer by Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang

“…In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. …”
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“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. …”
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Cannabinoids: A New Group of Agonists of PPARs by Yan Sun, Andy Bennett

“…This demands that these new compounds be free of the psychotropic effects that connected with the recreational use of cannabinoids. In preclinical studies cannabinoids displayed many of the characteristics of nonsteroidal anti-inflammatory drugs (NSAIDs) and it seems to be free of unwanted side effects. …”
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Immune links in comorbid depression and psoriasis: A narrative mini-review and perspective by Georgia Lada

“…Despite an early interest in the brain-skin axis and the role of stress in psoriasis immunopathogenesis, there is ongoing limited preclinical and clinical research into the inflammatory links between depression and psoriasis. …”
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Interleukin 2-Based Fusion Proteins for the Treatment of Cancer by Alana MacDonald, T.-C. Wu, Chien-Fu Hung

“…The ability of IL-2 to mediate tumor regression in preclinical and clinical settings led to FDA approval for its use in the treatment of metastatic renal cell carcinoma and metastatic melanoma in the 1990s. …”
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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

“…However, to date there are few preclinical models that accurately represent these disparate disease scenarios.Methods Using combinatorial radio-immunotherapy consisting of PD-1 blockade, IL2Rβγ biased signaling, and OX40 agonism we were able to generate preclinical tumor models with conflicting responses, where head and neck squamous cell carcinoma (HNSCC) models respond and pancreatic ductal adenocarcinoma (PDAC) progresses.Results By modeling these disparate states, we find that regulatory T cells (Tregs) are expanded in PDAC tumors undergoing treatment, constraining tumor reactive CD8 T cell activity. …”
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Assessment of Convergence Angle of Tooth Preparations for Complete Crowns Among Dental Students: Typodont vs Simulator by Meriem Amine, Hafsa Oumayma Wahid, Saliha Fahi, Safaa Lehmouddi, Mouna Hamza, Samira Elarabi

“…Are students able to reproduce, in preclinical, total occlusal convergence (TOC) angles recommended on typodont and simulator? …”
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Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes by Loredana Bucciarelli, Daniele Andreini, Giulio Stefanini, Roberta Maria Fiorina, Marco Francone, Federica Catapano, Maria Elena Lunati, Edoardo Conte, Davide Marchetti, Paolo Fiorina

“…In this review, we are revisiting the existence of atherosclerosis regression in preclinical and clinical studies, with a focus on the latest mechanistic insights and on the newest pharmacological agents, particularly in patients with diabetes. …”
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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

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Mesenchymal Stem Cells and Tissue Bioengineering Applications in Sheep as Ideal Model by Talita D’Paula Tavares Pereira Muniz, Mariana Correa Rossi, Vânia Maria de Vasconcelos Machado, Ana Liz Garcia Alves

“…This review aimed to describe recent MSC approaches, including those associated with biomaterials, from experimental, clinical, and preclinical studies with sheep models.…”
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The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds) by Agnieszka Owczarczyk-Saczonek, Anna Wociór, Waldemar Placek, Wojciech Maksymowicz, Joanna Wojtkiewicz

“…The promising results derived from the use of adipose-derived stem cells (ADSCs) in many diseases are a subject of observation in preclinical studies. ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. …”
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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…TIM-3 and LAG-3), have shown potential to reverse NK cell exhaustion in preclinical studies. This article explores the promise of these innovative strategies in HCC immunotherapy, providing new therapeutic directions for optimizing NK cell function and improving drug sensitivity.…”
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The Impact of the Myeloid Response to Radiation Therapy by Michael J. Gough, Kristina Young, Marka Crittenden

“…Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. …”
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Colorectal Polyposis and Immune-Based Therapies by Pearl Jacobson-Brown, Manuela G Neuman

“…A broad spectrum of new treatments, including innovative molecular therapies such as gene therapy and treatment with cytokines, is under experimental and preclinical investigation. Nonsteroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors have traditionally been used as inflammation-reducing agents in cases of colon adenoma. …”
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Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy by Jasmin S. Nurković, Radiša Vojinović, Zana Dolićanin

“…Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. …”
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