Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer by Qingqing Meng, Zheng Li

“…Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. …”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. …”
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Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis by Matthew D. Silva, Jason Ruan, Elizabeth Siebert, Anneli Savinainen, Bruce Jaffee, Lisa Schopf, Sudeep Chandra

“…Quantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. …”
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Practical Vessel Imaging by Computed Tomography in Live Transgenic Mouse Models for Human Tumors by Gordon L. Kindlmann, David M. Weinstein, Greg M. Jones, Christopher R. Johnson, Mario R. Capecchi, Charles Keller

“…This study lays a groundwork for the qualitative and quantitative assessment of anti-angiogenesis preclinical studies using transgenic mice.…”
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Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential by M. Isakson, C. de Blacam, D. Whelan, A. McArdle, A. J. P. Clover

“…This review examines the body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies and also the possible mechanisms controlling its efficacy. …”
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Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy by Maurizio Ceppi, Bruno Gomes, Simon Deycmar, Jehad Charo, J Mark Cline

“…The complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. …”
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Measuring Brain Tumor Growth: Combined Bioluminescence Imaging–Magnetic Resonance Imaging Strategy by Sarah C. Jost, Lynne Collins, Sarah Travers, David Piwnica-Worms, Joel R. Garbow

“…The results led us to suggest a cost-effective, multimodality strategy for selecting cohorts of animals with similar tumor growth patterns that improves the accuracy of longitudinal in vivo measurements of tumor growth and treatment response in preclinical therapeutic studies.…”
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Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome by Jibin Han, Yanmin Li, Yuanyuan Li

“…Accordingly, several strategies have been explored to improve MSC retention in the lung and enhance the innate properties of MSCs in preclinical models of ARDS. To provide a comprehensive and updated view, we summarize a large body of experimental evidence for a variety of strategies directed towards strengthening the therapeutic potential of MSCs in ARDS.…”
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Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration by Gloria Huerta-Ángeles, Edgar Mixcoha

“…This review reports many of the latest developments of hyaluronan and its derivatives in research, preclinical, and published clinical trials for wound healing. …”
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Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs by Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar

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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth Iceland, Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…To address resistance, most preclinical studies increased the dosage and the treatment time, and this failed to improve the patient’s prognosis. …”
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Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques by Elena Rodriguez, Charrell M. Bullard, Milena H. Armani, Thomas L. Miller, Thomas H. Shaffer

“…The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.…”
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Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions by Sarah Bibi Mungly, Evelyn Priya Peter, Ling-Wei Hii, Chun-Wai Mai, Felicia Fei-Lei Chung

“…In this review, we summarise and present the preclinical and clinical evidence for epigenetic drugs in treating breast cancer. …”
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Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…The current review provides an update on novel approaches, preclinical, clinical evidence, and delivery route of ASOs. …”
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The Potential of Curcumin in Treatment of Spinal Cord Injury by Raghavendra Sanivarapu, Vijayalakshmi Vallabhaneni, Vivek Verma

“…We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy.…”
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Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges by Claire MacNabb, D. Patton, J. S. Hayes

“…In anticipation of phase III trial results which may potentially signify a significant step in achieving market approval here, we review the preclinical and clinical emergence of sclerostin antibody therapies for both osteoporosis and alternative applications. …”
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Hubungan antara Kebiasaan Olahraga dengan Dismenore pada Mahasiswi Pre-Klinik Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas Tahun Ajaran 2012 - 2013 by Ayu Anissa Bahri, Afriwardi , Yusrawati

“…The population of this study were all female preclinical students of Medical Faculty Andalas University in academic<br />year 2012-2013. …”
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Establishment and characterization of a new mouse gastric carcinoma cell line, MCC by Yushen Wang, Xianju Li, Yi Wang, Jun Qin

“…By integrating proteomic profiles from clinical gastric cancer patients and the murine subcutaneous tumor model, several molecular targets suitable for preclinical investigation were identified. Trametinib, a MEK inhibitor, was employed as a model compound in our preclinical study. …”
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Interactions of miR-34b/c and TP53 Polymorphisms on the Risk of Intracranial Aneurysm by Lijuan Li, Xiutian Sima, Peng Bai, Lushun Zhang, Hong Sun, Weibo Liang, Jianxing Liu, Lin Zhang, Linbo Gao

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Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects by Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes, Andrew M. Scott

“…Notably, cancer-associated fibroblasts (CAFs) have emerged as one of the primary contributors in shaping TME, creating a favourable environment for cancer development. Many preclinical studies have identified promising targets on CAFs, demonstrating remarkable efficacy of some CAF-targeted treatments in preclinical models. …”
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