Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

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Dyspareunia is rarely assessed in rodent models of endometriosis and interstitial cystitis/bladder pain syndrome by Paulina Nunez-Badinez, Razneen Shah, Lysia Demetriou, Bianca De Leo, Jane Meijlink, Judy Birch, Nicole Schmidt, Jens Nagel, Katy Vincent

“…This review evaluates how dyspareunia has been addressed in preclinical investigations of these conditions. A systematic search was conducted using Embase from 1998 to 2021, identifying original in vivo preclinical studies using female rodents to model (i) endometriosis and (ii) IC/BPS. …”
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Rethinking Assessment Concepts in Dental Education by Mohamed El-Kishawi, Khaled Khalaf, Dana Al-Najjar, Zahra Seraj, Sausan Al Kawas

“…The following key terms, clinical skills, preclinical, dental students, and assessment, were included in the search. …”
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Rotation errors in path integration are associated with Alzheimer’s disease tau pathology: a cross-sectional study by Lise Colmant, Lisa Quenon, Lara Huyghe, Adrian Ivanoiu, Thomas Gérard, Renaud Lhommel, Pauline Coppens, Yasmine Salman, Vincent Malotaux, Laurence Dricot, Lukas Kunz, Nikolai Axmacher, Philippe Lefèvre, Bernard Hanseeuw

“…Standard neuropsychological evaluation does not identify clinically normal individuals with brain amyloidosis, the first stage of the pathology, defined as preclinical Alzheimer’s disease. Spatial navigation assessment, in particular path integration, appears promising to detect preclinical symptoms, as the medial temporal lobe plays a key role in navigation and is the first cortical region affected by tau pathology. …”
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A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors by Umberto Cillo, Caterina Lonati, Alessandra Bertacco, Lucrezia Magnini, Michele Battistin, Liver NMP Consortium, Lara Borsetto, Francesco Dazzi, David Al-Adra, Enrico Gringeri, Maria Laura Bacci, Andrea Schlegel, Daniele Dondossola

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Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation by Jie Wang, Peiling Luo, Jingjie Zhao, Junhua Tan, Feifan Huang, Ruiying Ma, Peng Huang, Meiying Huang, Yuming Huang, Qiuju Wei, Liuzhi Wei, Zechen Wang, Lingzhang Meng

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Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies by Hidekazu Kawashima

“…This review outlines the fundamentals of RIT and current knowledge of the preclinical/clinical trials for cancer treatment.…”
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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation by Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman

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Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib by Bojan Labachevski, Dragica Zendelovska, Marija Petrushevska, Marija Popova-Labachevska, Aleksandra Pivkova-Veljanovska, Liljana Gjatovska-Labachevska, Nevenka Ridova, Sanja Trajkova, Irina Panovska-Stavridis, Trajan Balkanov

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The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction by Andrej Dzupina, Dominik Pella, Pavol Zenuch, Zuzana Zenuchova, Jaipaul Singh, Monika Jankajova, Jan Fedacko

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Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review by Mardiana L, Milanda T, Hadisaputri YE, Chaerunisaa AY

“…This review highlights the potential of phytosome-based formulations as a novel approach to anticancer therapy, supporting further development in preclinical, in vitro, and potential clinical applications. …”
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N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis by Bin Ma, Jing Li, Wen-Ke Yang, Mei-Gui Zhang, Xiao-Dong Xie, Zhong-Tian Bai

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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…Preclinical cancer studies have revealed increased activation of and infiltration by tumor-fighting immune cells, especially CD8+ T cells, but also M1 macrophages and natural killer cells, in response to a KD regimen. …”
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Potential Human Models of Infammatory Bowel Disease by Stephen B Hanauer

“…Current human models can be classified into models depicting risk of disease; preclinical disease; acute inflammation; and miscellaneous IBD. …”
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Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

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Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium by Eileen S. Kim, Jennifer E. Kim, Mira A. Patel, Antonella Mangraviti, Jacob Ruzevick, Michael Lim

“…Results from recent preclinical and clinical studies demonstrate how checkpoint inhibition can be utilized to prevent tumor immune evasion and both local and systemic immune suppression. …”
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The Pharmacotherapy of Chronic Pain: A Review by Mary E Lynch, C Peter N Watson

“…The past two decades have contributed a large body of preclinical work that has assisted in our understanding of the underlying pathophysiological mechanisms that cause chronic pain. …”
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MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives by Michael Karin, Ju Youn Kim

“…Numerous preclinical models have been created but not many mimicked anthropometric measures and the course of disease progression shown in the patients. …”
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Near-Infrared Imaging of Injured Tissue in Living Subjects Using IR-820 by Suresh I. Prajapati, Carlo O. Martinez, Ali N. Bahadur, Isabel Q. Wu, Wei Zheng, James D. Lechleiter, Linda M. McManus, Gary B. Chisholm, Joel E. Michalek, Paula K. Shireman, Charles Keller

“…The unprecedented increase in preclinical studies necessitates high-throughput, inexpensive, and straightforward methods for evaluating diseased tissues. …”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth, Iceland Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…To address resistance, most preclinical studies increased the dosage and the treatment time, and this failed to improve the patient’s prognosis. …”
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