Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…The current review provides an update on novel approaches, preclinical, clinical evidence, and delivery route of ASOs. …”
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The Potential of Curcumin in Treatment of Spinal Cord Injury by Raghavendra Sanivarapu, Vijayalakshmi Vallabhaneni, Vivek Verma

“…We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy.…”
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Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges by Claire MacNabb, D. Patton, J. S. Hayes

“…In anticipation of phase III trial results which may potentially signify a significant step in achieving market approval here, we review the preclinical and clinical emergence of sclerostin antibody therapies for both osteoporosis and alternative applications. …”
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Hubungan antara Kebiasaan Olahraga dengan Dismenore pada Mahasiswi Pre-Klinik Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas Tahun Ajaran 2012 - 2013 by Ayu Anissa Bahri, Afriwardi , Yusrawati

“…The population of this study were all female preclinical students of Medical Faculty Andalas University in academic<br />year 2012-2013. …”
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Establishment and characterization of a new mouse gastric carcinoma cell line, MCC by Yushen Wang, Xianju Li, Yi Wang, Jun Qin

“…By integrating proteomic profiles from clinical gastric cancer patients and the murine subcutaneous tumor model, several molecular targets suitable for preclinical investigation were identified. Trametinib, a MEK inhibitor, was employed as a model compound in our preclinical study. …”
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Interactions of miR-34b/c and TP53 Polymorphisms on the Risk of Intracranial Aneurysm by Lijuan Li, Xiutian Sima, Peng Bai, Lushun Zhang, Hong Sun, Weibo Liang, Jianxing Liu, Lin Zhang, Linbo Gao

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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…As the field develops and evolves, there is a need for standardized frameworks for generation, culture, storage, and analysis of intestinal organoids to ensure reproducibility, comparability, and interpretability of these preclinical and clinical studies to ultimately enable clinical translation.…”
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Metabotropic Glutamate Receptors for Parkinson's Disease Therapy by Fabrizio Gasparini, Thérèse Di Paolo, Baltazar Gomez-Mancilla

“…Metabotropic receptor (mGlu receptor) modulators were considered to have a more favourable side-effect profile, and several agents have been studied in preclinical models of PD. The most promising results have been seen clinically with selective antagonists of mGlu5 receptor and preclinically with selective positive allosteric modulators of mGlu4 receptor. …”
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Prevalence of Plaque Induced Gingivitis Among Dental Students in College of Dentistry, Hawler Medical University. by Zainab Salim Mahmood, Qehraman Ismayil Ahmed, Ahmed Luqman Saifullah

“…Method: The study enrolled 120 (65 male, 55 female) dental students from different years of study including both clinical and preclinical years. Intra-oral clinical parameters including (plaque index, gingival index, bleeding on probing) were recorded to evaluate the students’ periodontal health status. …”
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Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

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Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration by Hossein Rayat Pisheh, Mahsa Sani

“…Despite the growing interest, there remains a lack of comprehensive reviews synthesizing the molecular mechanisms, preclinical, and clinical evidence related to the specific role of MSC-derived exosomes in cardiac therapies. …”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

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Automatic Adaptive Algorithm for Delineation of Cerebral-Spinal Fluid Regions for Non-contrast Magnetic Resonance Imaging Volumetry and Cisternography in Mice by Ryszard Gomolka

“…This study presents a novel analytical algorithm developed in MATLAB for the automatic segmentation of cerebrospinal fluid (CSF) spaces in preclinical non-contrast MR images of the mouse brain. …”
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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…As such, PET imaging has long been used as a tool to aid drug discovery programs from preclinical biomarker validation all the way through to clinical trials. …”
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Exploring Cervical Adenocarcinoma: Epidemiological Insights, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms by Shuhui Li, Congrong Liu, Liang Weng

“…Additionally, we also summarize the common preclinical models for CA and discuss the advantages and disadvantages of using various models in research. …”
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Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease by Anelya Kh. Alieva, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Petr A. Slominsky, Maria I. Shadrina

“…Based on these results, it can be suggested that the upregulation of the mRNA levels of ATP13A2, PARK7, and ZNF746 in untreated patients in the earliest clinical stages can also be observed in the preclinical stages of PD, and that these genes can be considered as potential biomarkers of the preclinical stage of PD.…”
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Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture by Ryan C. Gessner, C. Brandon Frederick, F. Stuart Foster, Paul A. Dayton

“…These preliminary images provide visually compelling evidence to suggest that acoustic angiography may serve as a powerful new tool in preclinical and future clinical imaging.…”
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Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers by A.N.K.V. Sravani, John Thomas

“…Although there is extensive preclinical evidence regarding EMT's function in the development of cancer, there is still a deficiency in clinical translation at the therapeutic level. …”
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Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies by Ravi Kumar Madireddy, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta

“…The present study demonstrates a broad-spectrum toxicological evaluation of LN18178 utilizing in vitro and in vivo preclinical models following the Organization for Economic Cooperation and Development (OECD) guidelines for testing chemicals. …”
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A refined, minimally invasive, reproducible ovine ischaemia–reperfusion–infarction model using implantable defibrillators: Methodology and validation by Charlene Pius, Barbara Niort, Emma J. Radcliffe, Andrew W. Trafford

“…Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising from ischaemic heart disease and the identification of sites for new therapeutic interventions requires a preclinical model that reproduces the key clinical characteristics of myocardial ischaemia, reperfusion and infarction. …”
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