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Artificial Intelligence Transforming Post-Translational Modification Research
Published 2024-12-01Subjects: Get full text
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Implication of protein post translational modifications in gastric cancer
Published 2025-02-01“…Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. …”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer
Published 2025-01-01Subjects: Get full text
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A computational tool to infer enzyme activity using post-translational modification profiling data
Published 2025-01-01“…Moreover, it is challenging to derive the activity of enzymes from proteome-wide post-translational modification (PTM) profiling data. To address this challenge, we introduce enzyme activity inference with structural equation modeling under the JUMP umbrella (JUMPsem), a novel computational tool designed to infer enzyme activity using PTM profiling data. …”
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The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
Published 2025-01-01“…In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes. …”
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H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts
Published 2025-01-01Subjects: “…H3K9 post-translational modifications…”
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A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications
Published 2016-01-01“…The growing interest in the characterization of protein post-translational modifications and the importance of handling large datasets using a systems biology approach are also discussed.…”
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Post-translational modifications as a key mechanism for herpes simplex virus type I evasion of host innate immunity
Published 2025-02-01Subjects: Get full text
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A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression
Published 2025-01-01Subjects: Get full text
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Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella
Published 2025-02-01Subjects: Get full text
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain
Published 2025-01-01Subjects: “…Post-translational modification…”
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Comparative Structural and Biophysical Investigation of <i>Lycosa erythrognatha</i> Toxin I (LyeTx I) and Its Analog LyeTx I-b
Published 2025-01-01Subjects: Get full text
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XGBoost-enhanced ensemble model using discriminative hybrid features for the prediction of sumoylation sites
Published 2025-02-01Subjects: Get full text
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Acetylation-enhanced Sp1 transcriptional activity suppresses Mlph expression
Published 2025-01-01Subjects: Get full text
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From canonical to unique: extension of a lipophilicity scale of amino acids to non-standard residues
Published 2024-07-01Subjects: Get full text
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