Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Multi‐omics sequencings of the lower respiratory tract possess the potential to predict the long‐term clinical responses to ICB among advanced NSCLC.…”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…Strikingly, we found that one-third of this cohort possessed a TRBV allele haplotype that appeared to be protective against severe irAEs.Conclusion The data suggest that long-amplicon TCRB repertoire sequencing can potentially identify TRBV haplotype groups that correlate with the risk of severe irAEs. …”
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Enhancing the ductility of cast Mg-Li alloys via dispersed α-Mg phase mitigating the dimension and distribution of interspersed eutectics along grain boundaries by Yu Wang, Ziyang Xia, Jingpeng Xiong, Gang Zeng, Penghao Wang, Lan Luo, Ruizhi Wu, Jian Wang, Yong Liu

“…Mg-Li alloys with high lithium concentrations possess a lightweight body-centered cubic (BCC) matrix structure (β-Li). …”
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Sewage sludge-based organomineral fertilizer: A pathway to enhanced soil fertility and chickpea production by Athos Rodrigues Soares Viana, Rodinei Facco Pegoraro, Regynaldo Arruda Sampaio, Luiz Arnaldo Fernandes, Leidivan Almeida Frazão, Cândido Alves da Costa, Verônica Aparecida Santos Ferreira Soares

“… Purpose: Sewage sludge compounds possess physical and chemical attributes that make them well-suited for formulating fertilizers intended for agricultural purposes. …”
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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction by Zhi-rong Luo, Han Li, Zhong-xin Xiao, Shui-jin Shao, Tian-tian Zhao, Yue Zhao, Fang-fang Mou, Bo Yu, Hai-dong Guo

“…In summary, THSWD may possess a beneficial effect on cardiac function by improving the local ischemic microenvironment and by decreasing mitochondrial fission after MI. …”
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Linkage Analysis between Solid-Fluid Coupling and the Strength Reduction Method for Karst Cave Water Inrush in Mines by Yanlin Zhao, Jian Liao, Qiang Liu, Yang Li, Jianchao Cheng

“…The reason leading to Karst water inrush of Qiyi Mine is that without advanced boreholes, the water-proof rock pillar is set so small that it could not possess safety margin, so the confined Karst cave water breaks the water-proof rock pillar and bursts out. …”
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Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells by Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang

“…Beyond regulating p53, MDM2 possesses p53-independent activity in promoting cell cycle progression and tumorigenesis via its RING domain ubiquitin E3 ligase activity. …”
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Impact of pharmacist-led educational intervention on knowledge of self-management among asthmatic patients: a prospective cohort study by Ahmad Khan, Saima Mushtaq, Amjad Khan, Nafees Ahmad, Shahzadi Sidra Saleem, Rubina Aman, Shahzadi Sadia Saleem, Ayesha Bibi, Saifullah Mehsud, Ivan R Green, Sheikh Abdur Rashid, Kifayat Ullah Shah

“…The administration of educational intervention protocols resulted in significantly improved level of knowledge of asthma self-management (<0.001) in the treatment group (mean ASMQ score improved from 4.20 to 9.77).Conclusion On baseline visit, patients possessed a poor knowledge about asthma self-management. …”
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Comprehensive analysis of metabolomics and transcriptomics reveals varied tepal pigmentation across Gloriosa varieties by Yue Sun, Pinli Hu, Yanan Jiang, Zhenzhen Wang, Jiaxing Chang, Yiwei Zhou, Haojing Shao

“…Abstract Gloriosa L. possesses exceptional ornamental value, with its floral hues exhibiting a wide range of variations. …”
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Morphology, phylogeography, phylogeny, and taxonomy of Cyclorhiza (Apiaceae) by Bo-Ni Song, Xueyimu Aou, Rong-Ming Tian, Jing Cai, Wei-Yan Tan, Chang-Kun Liu, Chang-Kun Liu, Xing-Jin He, Song-Dong Zhou

“…Finally, we performed the phylogenetic analyses based on three datasets (plastome data, ITS sequences, and haplotypes) and estimated the origin and divergence time of the genus.Results and discussionThe morphology of Cyclorhiza plants and S. purpureovaginatum was highly similar, and their plastomes in structure and features were conserved. The genus possessed high genetic diversity and significant lineage geographic structure, which may be associated with the long-term evolutionary history, complex terrain and habitat, and its sexual reproduction mode. …”
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Comparative Evaluation of Different Mint Species Based on Their In Vitro Antioxidant and Antibacterial Effect by Ameni Sfaxi, Szilvia Tavaszi-Sárosi, Kovács Flórián, Katalin Patonay, Péter Radácsi, Ákos Juhász

“…The least effective oil in the case of Gram-negative bacteria was bergamot mint (inhibition zone: 7.67–8.67 mm, MIC: 2.00, >2.00 <i>v</i>/<i>v</i>%, IC₅₀: 0.11–0.25 <i>v</i>/<i>v</i>%, MBC: 2.00, >2.00 <i>v</i>/<i>v</i>%), while in the case of Gram-positive bacteria, oils containing dihydrocarvone as the main compound possessed the weakest antibacterial effect (inhibition zone: 9.00–10.00 mm, MIC: 1.00–2.00 <i>v</i>/<i>v</i>%, IC₅₀: 0.22–0.37 <i>v</i>/<i>v</i>%, MBC: >2.00 <i>v</i>/<i>v</i>%). …”
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Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Pyrus calleryana fruit) by Huan Zhao, Huan Zhao, Qinqin Wang, Lanlan Yang, Lanlan Yang, Yuanquan Ran, Qiong Hu, Yi Hong, Minyi Tian, Minyi Tian, Minyi Tian

“…Our findings suggested that P. calleryana fruit WE and EE possess significant antioxidant, anti-inflammatory, α-glucosidase, and tyrosinase inhibitory properties. …”
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Allelic variants for Waxy genes in common wheat lines bred at the Lukyanenko National Grain Center by E. R. Davoyan, L. A. Bespalova, R. O. Davoyan, E. V. Agaeva, G. I. Bukreeva, Yu. S. Zubanova, D. S. Mikov, D. M. Boldakov

“…Selected lines found to possess null alleles of the Wx genes are applicable in breeding programs aimed at the improvement of technological qualities of grain and raise of bread wheat varieties with modified starch properties.…”
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Comparing prediction accuracy for 30-day readmission following primary total knee arthroplasty: the ACS-NSQIP risk calculator versus a novel artificial neural network model by Anirudh Buddhiraju, Michelle Riyo Shimizu, Tony Lin-Wei Chen, Henry Hojoon Seo, Blake M. Bacevich, Pengwei Xiao, Young-Min Kwon

“…Although both models possessed similar accuracy (Brier score: ANN = 0.03; SRC = 0.02), only the ANN demonstrated a higher net benefit than intervening in all or no patients on the decision curve analysis. …”
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The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum by Alexander A. Morano, Wei Xu, Francesca M. Navarro, Neeta Shadija, Jeffrey D. Dvorin, Hangjun Ke

“…PfDyn2’s singular role in mediating both apicoplast and mitochondrial fission has not been observed in other organisms possessing two endosymbiotic organelles, including other Apicomplexans, thus reflecting a unique, potentially exploitable method of organellar division in P. falciparum.IMPORTANCEPlasmodium falciparum remains a significant global pathogen, causing over 200 million infections and over 600,000 deaths per year. …”
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Knowledge, attitude and practices associated with COVID-19 among undergraduate students from Malaysian public universities during the endemic phase: a cross-sectional study by Nur Umairah Mohd Hawary, Nor Malia Abd Warif, Ismarulyusda Ishak, Arimi Fitri Mat Ludin, Barathan Muttiah, Navindra Kumari P, Kumutha Malar Vellasamy, Vanitha Mariappan

“…Results Around 73% of the respondents had good knowledge of COVID-19, 58.6% possessed positive attitudes, and 54.6% were classified as having good practices in COVID-19 prevention. …”
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IDENTIFIKASI PEMBEKALAN KETERAMPILAN ABAD 21 PADA ASPEK LITERASI TEKNOLOGI INFORMASI DAN KOMUNIKASI SISWA SMA NEGERI BENGKULU DALAM MATA PELAJARAN FISIKA by Annisatul Jannah, Afrizal Mayub, Dedy Hamdani

“…Kata Kunci: pembekalan, keterampilan abad 21, keterampilan literasi teknologi informasi dan komunikasi, pelajaran fisika, descriptive reasearch   ABSTRACT   This reasearch has aimed to (1) to describe debriefing of  century skills on aspects of LTIK skills that have been given to students according to the perceptions of Bengkulu city high school teachers in physics subjects. (2) to describe debriefing of  century skills on aspects of LTIK skills that have been carried out by teachers according to the perceptions of Bengkulu city high school students in physics subjects. (3) describe the provision of 21st century skills in aspects of information and communication technology literacy skills possessed by students according to their own perception of bengkulu high school students in physics subjects. (4) describe the provision of  century skills in aspects of LTIK skills that students have according to their own perceptions of high school students in Bengkulu City in physics. …”
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Examining the Impact of Cognitive and Emotional Factors on Consumer Behavioral Responses in Online Behavioral Advertising by Hossein Norouzi, Bahareh Osanlou, Ali Saleh Gohari

“…Additionally, information control demonstrates a negative impact on perceived intrusiveness and privacy concerns, while persuasion knowledge exhibits a positive correlation with privacy concerns. Consumers possessing high levels of persuasion knowledge express increased privacy concerns regarding OBA. …”
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Automatic segmentation model and machine learning model grounded in ultrasound radiomics for distinguishing between low malignant risk and intermediate-high malignant risk of adnex... by Lu Liu, Wenjun Cai, Feibo Zheng, Hongyan Tian, Yanping Li, Ting Wang, Xiaonan Chen, Wenjing Zhu

“…The machine learning model possesses the capability to enhance the proficiency of less-experienced radiologists. …”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…It seems that they anchor their gaze on the player's possession of the ball to monitor peripheral events (e.g., movements of other players). …”
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