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    In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging β-Glucuronidase Activity in a Tumor/Inflammation Rodent Model by Iněs F. Antunes, Hidde J. Haisma, Philip H. Elsinga, Aren van Waarde, Antoon T.M. Willemsen, Rudi A. Dierckx, Erik F.J. de Vries

    Published 2012-01-01
    “…To investigate the role of β-GUS in pathologies and to optimize β-GUS-based prodrug therapies, we recently developed a positron emission tomographic (PET) tracer, 1-O-(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-D>-glucopyronuronate ([ 18 F]FEAnGA), which proved to be selectively cleaved by β-GUS. …”
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