Arginase-1-specific T cells target and modulate tumor-associated macrophages by Mads Hald Andersen, Inés Lecoq, Ayako Wakatsuki Pedersen, Evelina Martinenaite, Shamaila Munir Ahmad, Maria Perez-Penco, Lucia Lara de la Torre, Marion Chapellier, Lars Rønn Olsen, Mia Aaboe-Jørgensen, Hannah Jorinde Glöckner, Anne Mette Askehøj Rømer

“…The effect of Arg1-derived peptide IMV on TAMs in vivo was assessed by multiplex gene analysis of F4/80+cells.Results We show that Arg1-based IMV-mediated tumor control was linked to a decrease in multiple immunosuppressive pathways in the TAM population of the treated animals. Tumor-conditioned media (TCM) derived from Arg1-vaccinated mice induced significantly higher upregulation of MHC-II on exposed myeloid cells compared with controls. …”
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Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking by Xiao-Yao Li, Bei-Yuan Zhang, Xin-Ran Liang, Yan-Yu Han, Min-Hua Cheng, Mei Wei, Ke Cao, Xian-Cheng Chen, Ming Chen, Jian-Feng Duan, Wen-Kui Yu

“…A biogenic analysis was performed to study the population frequency, conservation, and electric potential diagram of the new variant p.K327N. …”
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Associations of dietary choline intake and kidney function with hyperuricemia in Chinese children and adolescents: a cross-sectional studyResearch in context by Chengping Li, Jing Li, Zhiquan Diao, Lianhong Chen, Siwen Yu, Lianlong Yu, Qianrang Zhu, Xiaomei Dong, Yiya Liu, Tao Liu, Dan Liu

“…We aim to investigate the associations between choline intake and hyperuricemia (HUA), as well as the mediating role of kidney function in this relationship, among the Chinese population aged 6–17 years. Methods: Participants were divided into quartiles according to residual energy-adjusted dietary choline intake in our cross-sectional study. …”
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Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012 by Zou W, Ou J, Wu F, Xiao S, Deng Z, Li H, Wang Z, Tang G, Liu S, Ye D, Zhu D, Hu J, Ran P

“…Weifeng Zou,1,2,* Jie Ou,1,2,* Fan Wu,3,4,* Shan Xiao,5 Zhishan Deng,3 Haiqing Li,3 Zihui Wang,3 Gaoying Tang,3 Shuling Liu,1 Dong Ye,6 Dongshuang Zhu,2 Jinxing Hu,1 Pixin Ran3,4 1State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Shufu County People’s Hospital, Kashgar region, Xinjiang, People’s Republic of China; 3State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Guangzhou National Laboratory, Guangzhou, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Shenzhen Longgang District Central Hospital, Shenzhen, People’s Republic of China; 6Department of Internal Medicine, Guangdong Province Second People’s Hospital, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fan Wu; Pixin Ran, State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Center for Respiratory Medicine & National Clinical Research Center for Respiratory Disease & The First Affiliated Hospital of Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, 510120, People’s Republic of China, Email wu.fan@vip.163.com; pxran@gzhmu.edu.cnBackground: It is unclear whether patients with Global Initiative for Chronic Obstructive Lung Disease stage 1 (mild) chronic obstructive pulmonary disease (COPD) have a higher risk of all-cause mortality than participants with normal spirometry results.Methods: We used the data from the National Health and Nutrition Examination Survey (NHANES) III and 2007– 2012, which included participants aged 20– 79 years, to investigate whether patients with mild COPD (whole population and subgroups) have a higher risk of all-cause mortality than participants with normal spirometry. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…These findings not only contribute to a deeper understanding of the diversity and geographical distribution of human bacteria but also enrich the microbiome data of the Asian population for further studies.…”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…A composite feed additive formulated to reduce the methanogenic archaeal population without affecting fibrolytic rumen microbes has been demonstrated to increase milk production, antioxidant status, and immunity with abatement of enteric methane production in Murrah buffaloes. …”
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Exploring agronomic diversity and disease tolerance in soybeans to combat Cowpea mild mottle virus by H. Kuswantoro, S. Zubaidah, E. Uge, K. Rozana, P. Purwantoro, J. Purnomo

“…To set up the experiment, a population of Bemisia tabaci carrying the Cowpea mild mottle virus was established in the field, enabling natural biotic environmental stress of the plants by the virus infection. …”
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Penerapan Model Technology Readiness Index untuk Mengukur Tingkat Kesiapan Mahasiswa dalam Penerimaan Sistem E-Polvot by M Khairul Anam, Fransiskus Zoromi, Soni, Torkis Nasution, Khusaeri Andesa

“…The analysis of students' readiness utilizes the Technology Readiness Index (TRI) model, which consists of four variables: Optimism, Innovativeness, Discomfort, and Insecurity. The population used for this study comprises all students of STMIK Amik Riau, and the total sampling technique is employed. …”
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Climats et origines des grands singes et des hommes by Brigitte Senut

“…Un scénario proposé par Coppens en 1981 supposait que l’Afrique orientale était le berceau des origines en lien avec l'ouverture du Rift africain qui allait isoler une population d'hominoïdes en deux: celle située à l'ouest allait évoluer vers les gorilles et les chimpanzés, alors que celle située à l'est allait donner naissance à l'homme. …”
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Impact of surgical site infection (SSI) following gynaecological cancer surgery in the UK: a trainee-led multicentre audit and service evaluation by Rachel L O’Donnell, Georgios Angelopoulos, James P Beirne, Ioannis Biliatis, Helen Bolton, Melissa Bradbury, Elaine Craig, Ketan Gajjar, Michelle L Mackintosh, Wendy MacNab, Thumuluru Kavitha Madhuri, Mark McComiskey, Eva Myriokefalitaki, Claire L Newton, Nithya Ratnavelu, Sian E Taylor, Amudha Thangavelu, Sarah A Rhodes, Emma J Crosbie, Richard J Edmondson, Yee-Loi Louise Wan

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Assessment of Environmental Hazards and Vulnerability of The Rud–E-Shur, Rud-E-Shirin and Rud-E-Minab International Wetland Using the DPSIR Model by Hengameh Safa Eisini, Saber Ghasemi, Afshin Danehkar, Mohsen Dehghani Ghanateghestani, Hossein Parvaresh

“…At the second stage, the intensity of the effect, the probability of occurrence and the sensitivity of the environment accepting the specified risks and threats are scored in five categories: very high, high, medium, low and very low (in the numerical range of 1 to 5) and finally using the method TOPSIS and TOPSIS Solver software were rated.Results: The results of the study showed that 30 risky factors including 24 human and 7 environmental origin cases; put living and existence of International Wetland into danger and risk. 5 threat indicators with human origin include population growth, human activities, excessive harvesting of ecosystem services, aquaculture, and management weakness; 2 threat indicators with environmental origin include drought and climate change have been prioritized. …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…These stratified associations were validated using two large population-based cohorts (the ABCD study; n = 1680, 11.92 ± 0.62 years; and UK Biobank, n = 20547, 55.38 ± 7.43 years). …”
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Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

“…This study highlights the value of neuroimaging studies in this population, and provides relevant information for prognostication.…”
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The authority of the printed word in the Lithuanian village of the XIX century by Džiuljeta Maskoliūnienė

“…The ability to read was rather limited for the major part of the population. They could read only "their own" prayer book, that is, the book they were taught to read (A. …”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…Natural killer (NK) cells emerged as a promising effector population that can be harnessed for anti-tumor therapy. …”
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Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution) by V. T. Ivashkin, V. V. Fomin, O. N. Tkacheva, O. S. Medvedev, E. A. Poluektova, D. I. Abdulganieva, S. R. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, M. S. Zharkova, O. Yu. Zolnikova, K. V. Ivashkin, I. L. Kliaritskaia, N. V. Korochanskaya, S. N. Mammaev, R. V. Maslennikov, R. G. Myazin, M. V. Perekalina, A. V. Povtoreyko, A. I. Ulyanin, M. V. Fadeeva, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin

“…Optimization of approaches to the diagnosis and treatment of SIBO, the development of domestic gas analyzers, increasing the awareness of physicians in all regions of the Russian Federation, as well as the development and optimization of clinical recommendations appear to be necessary measures to increase the effectiveness of medical care, the duration and quality of life of the Russian population. These goals can be achieved within the framework of Federal programs under the supervision of specialized reference centers of the Ministry of Health of the Russian Federation.…”
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Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study by Satoshi Kubota, Ai Sato, Manami Hosokawa, Yosuke Okubo, Shohei Takayama, Atsuko Kaneko, Yasuho Shimada, Yuki Asano, Yoshihiko Sato, Masanori Yamazaki, Mitsuhisa Komatsu

“…Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. …”
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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact by Liuqingqing Liu, Xinyao Li, Xianxiang Luo, Xiao Wang, Linjia Liu, Zixi Yuan, Cuizhu Sun, Hao Zheng, Elvis Genbo Xu, Fengmin Li

“…., dimethyl phthalate (DMP), di-n-butyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP), and their molecular mechanisms on juvenile Sebastes schlegelii, revealed alarming results from molecular to population levels. After a 20-day foodborne exposure at a low marine environmental concentration (1.0 μg g−1), we observed that all three PAEs significantly increased the thigmotaxis (behavioral tendency to stay close to physical boundaries) and mobility of juvenile fish by 28.2–59.4 % and 23.3–74.5 %, respectively, indicating anxiety-like behavior of fish. …”
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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…This study employed the widely recognized and commonly used technique of defining the review's scope in a focused manner by first identifying the population, intervention, comparison, and outcome. This study identified 358 studies, and 31 studies were included in the review after screening. …”
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Effect of retirement on the body mass index in China: a nationwide study based on the regression discontinuity design by Jiarun Mi, Xueyan Han, Hanchao Cheng, Zhaoyang Pan, Jian Guo, Hailu Zhu, Qi Wang, Yicong Wang, Yuanli Liu, Congyi Zheng, Xin Wang, Xue Cao, Zhen Hu, Yixin Tian, Zengwu Wang, Tianjia Guan

“…When considering adjustments to existing retirement policies, the differential health effects of retirement across various populations should be taken into account.…”
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