UPDATE ON CYTOMEGALOVIRUS INFECTION MANAGEMENT IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS by José Luis Piñana, Estela Giménez, Lourdes Vázquez, María Ángeles Marcos, Manuel Guerreiro, Rafael Duarte, Ariadna Pérez, Carlos de Miguel, Ildefonso Espigado, Marta González-Vicent, María Suarez-Lledó, Irene García-Cadenas, Rodrigo Martino, Angel Cedillo, Monserrat Rovira, Rafael de la Cámara, David Navarro, Carlos Solano

“…These recommendations aim to guide clinical practice and improve outcomes in this high-risk population. Further research is warranted to validate these recommendations and address ongoing challenges in CMV management with emerging antiviral combinations, particularly in pediatric populations. …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Therefore, we investigated if these symptoms are helpful for triage and diagnosis of ACS in females and males with acute chest discomfort.Design Cross-sectional study.Setting Nine out-of-hours service in primary care (OHS-PC) in the Netherlands participated, covering both rural and urban areas, serving a total population of 1.5 million people.Participants 2195 patients were selected calling the OHS-PC with acute chest discomfort, 55.4% were females. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

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Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…The rapid growth of the human population and urbanization has significantly increased the demand for animal proteins. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Se Chen,1 Zhonglei Wan2 1School of International Education, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, People’s Republic of China; 2Department of General Education, Jiangxi Youth Vocational College, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence: Se Chen, Jiangxi Science and Technology Normal University, 589 Xuefu Avenue, Nanchang, Jiangxi Province, 330038, People’s Republic of China, Tel +0086 – 18679059130, Email chense063@foxmail.comBackground: The rapid growth of the global aging population highlights the need to address ageism and promote social inclusiveness. …”
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Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages by Fred Owino, Fred Owino, Fred Owino, Caroline Kijogi, Caroline Kijogi, Caroline Kijogi, Omu Anzala, Omu Anzala, Edwin Walong, Obiero Jael, Steven G. Nyanjom, Agola Lelo Eric, Bernard N. Kanoi, Bernard N. Kanoi, Jesse Gitaka, Jesse Gitaka

“…Following enzymatic dissociation of placental tissue, immune cells were enriched from the total population of placental cells by density centrifugation. …”
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The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study by Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener

“…Cesarean delivery was more common among SSRI-treated mothers than in the general population (p < 0.001). Infants of SSRI-treated mothers had lower WHO-classified birthweight z-scores (-0.25 ± 0.93 vs -0.04 ± 0.92, p < 0.001) and a higher rate of small-for-gestational-age infants (13.4% vs 8.2%, p < 0.001). …”
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Hubungan Indeks Masa Tubuh dan Lingkar Perut dengan Low Density Lipoprotein pada Pasien Penyakit Jantung Koroner di Poliklinik Jantung RSUP Dr. M. Djamil Padang by Medika Prasetya, Fadil Oenzil, Yerizal Karani

“…The design of this study was a cross-sectional study to<br />collect primary data such as height, weight, and abdominal circumference, but LDL data got from medical records. The study population was all patients with coronary heart disease with normal LDL above 20 years old to 64 years who came from County/City of West Sumatra had been treated at the clinic Dr M. …”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Conclusions Persistent eGFRcre decrease to < 90 ml/min/1.73 m2 after switch to DTG was common in this Thai population. eGFRcystC was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…Future studies should be designed to further interrogate our findings, while accommodating for nuances specific to the paediatric deceased-donor population and their families. …”
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Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice by Lifeng Zheng, Chao Lan, Xinyue Gao, An Zhu, Yaoqing Chen, Jinluan Lin, Sunjie Yan, Ximei Shen

“…Osteoporosis (OP) is a prevalent chronic bone metabolic disorder that affects the elderly population, leading to an increased susceptibility to bone fragility. …”
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Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People by Weiwei Hu, Jinwei He, Luyue Qi, Chun Wang, Hua Yue, Jiemei Gu, Hao Zhang, Yi Wang, Zhenlin Zhang

“…This study was designed to study the GWAS of osteoporosis in Shanghai Han population. Methods. We collected 1224 unrelated healthy young men (20–40 years old), young women (20–40 years old), and postmenopausal women (over 50 years old) who lived in Shanghai. …”
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Self-Perceived Barriers to Pediatric Cancer Care in Sub-Saharan Africa: A Cross-Sectional Multinational Study by Ole Stoeter, Nikolaus C.S. Mezger, Tamara Koenig, Eric Chokunonga, Girum Tessema, Adugna Fekadu Damise, Alda Stevy Makouanzi, Esther Majaliwa, Mahine Ivanga, Bakarou Kamate, Franck Gnahatin, Sarah Nambooze, Ima-Obong A. Ekanem, Toralf Bernig, Biying Liu, Sumit Gupta, Eva Johanna Kantelhardt

“…Our study explored barriers to CC treatment from a patient's perspective to guide the health care providers.METHODSFrom February to September 2021, we conducted a multinational cross-sectional study with a sample from nine population-based cancer registries in nine sub-Saharan countries. …”
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Length of stay after colorectal surgery in Italy: the gap between “fit for” and “actual” discharge in a prospective cohort of 4529 cases by Lorenzo Pandolfini, Duccio Conti, Piercarlo Ballo, Silvia Rollo, Alessandro Falsetto, Gian Matteo Paroli, Paolo Ciano, Michele Benedetti, Leonardo Antonio Montemurro, Giacomo Ruffo, Massimo Giuseppe Viola, Felice Borghi, Gianandrea Baldazzi, Massimo Basti, Pierluigi Marini, Mariano Fortunato Armellino, Vincenzo Bottino, Giovanni Ciaccio, Alessandro Carrara, Gianluca Guercioni, Marco Scatizzi, Marco Catarci, the Italian ColoRectal Anastomotic Leakage (iCral) study group

“…The association between the gap and the LOS in the whole population was then assessed through a multivariate regression model including other confounding variables. …”
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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial by Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

“…Therefore, POLA1 expression may be predictive for CHK1i resistance, and the concurrent POLA1 inhibition may improve the efficacy of CHK1i monotherapy in this hard-to-treat population, deserving further investigation.…”
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Human papillomavirus vaccination hesitancy among young girls in Ethiopia: factors and barriers to uptake by Ashenafi Kibret Sendekie, Ashenafi Kibret Sendekie, Biruk Beletew Abate, Biruk Beletew Abate, Betelhem Anteneh Adamu, Aschalew Mulatu Tefera, Kaleab Temelket Mekonnen, Melkam Alemu Ashagrie, Yabibal Berie Tadesse, Abera Dessie Dagnaw, Mequannent Sharew Melaku, Gizachew Kassahun Bizuneh

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Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…Restricted cubic spline and sensitivity analyses were used to assess the association between DII and the degree of disability of the older adult population.ResultsInactivity (never exercising, OR = 8.48, 95% CI = 2.30–31.31) and reduced activity (formerly exercising, OR = 4.85, 95% CI = 1.39–16.96), stroke (OR = 2.78, 95% CI = 1.61–4.80), and dementia (OR = 2.69, 95% CI = 1.26–5.78) were significantly associated with increased disability. …”
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Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension by Marta Banaszkiewicz, Arkadiusz Pietrasik, Szymon Darocha, Michał Piłka, Michał Florczyk, Anna Dobosiewicz, Piotr Kędzierski, Ewa Pędzich-Placha, Janusz Kochman, Grzegorz Opolski, Adam Torbicki, Marcin Kurzyna

“…Results The median sST2 concentration was 32.8 ng/ml (IQR: 21.6–48.5 ng/ml) in the whole study population. Significant differences were found between median sST2 in successive WHO FCs (FC II vs. …”
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Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort... by Raj Tummala, Richard A Furie, Laurent Arnaud, Eric F Morand, Martin Aringer, Stephanie Chen, Barnabas Desta, Alberta Hoi, Bo Ding, Christine Peschken, Jonatan Hedberg, Tina Grünfeld Eén, Alessandro Sorrentino, Danuta Kielar

“…Subgroup analyses were stratified by baseline interferon gene signature (IFNGS) status and disease activity (SLEDAI-2K) status.Results Patient demographics and baseline characteristics were similar among subgroups; the majority of patients were on antimalarials (n=670; 81.1%), followed by glucocorticoids (n=537; 65.0%), immunosuppressants (n=453; 54.8%) and biologics (n=175; 21.2%). In the overall population, median (IQR) SLEDAI-2K scores decreased within 12 months (baseline: 8.0 (6.0–12.0); 12 months: 4.0 (2.0–8.0)) and remained stable thereafter. …”
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