CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…Therefore, the development of cell products with improved therapeutic indexes is highly demanded.Methods In this project, we investigated how CD4 and CD8 populations cooperate during CD19 CAR-T cell responses and what is their specific role in CRS development. …”
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Characterisation of HBV and co-infection with HDV and HIV through spatial transcriptomics by Upkar S Gill, Patrick T F Kennedy, Andrew Hall, Rageshri Dhairyawan, Alberto Quaglia, James M Harris, Colin Nixon, Fadi Issa, Amy Cross, Edward Arbe-Barnes, Jane A McKeating, Dimitra Peppa

“…Varied cellular characteristics and immune cell populations, with an abundance of γδT cells in the HDV/HBV sample, were observed within analysed regions. …”
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Comparative genomic analysis of ten Elizabethkingia anophelis isolated from clinical patients in China by Fei Wu, Yan Wu, Miaomiao Zhang, Lijun Tian, Xue Li, Xi Luo, Yiquan Zhang, Renfei Lu

“…The genomic features are important for further investigations of epidemiology, resistance, virulence, and to identify appropriate treatments.IMPORTANCEElizabethkingia anophelis strains are opportunistic pathogens causing meningitis, bloodstream infections, and endophthalmitis in vulnerable populations. There is a lack of knowledge of the genetic diversity, presence of antimicrobial resistance genes (AMRs), and virulence factors (VFs) in E. anophelis isolated from clinical patients in China. …”
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User Experience of a Semi-Immersive Musical Serious Game to Stimulate Cognitive Functions in Hospitalized Older Patients: Questionnaire Study by Laurent Samson, Lena Carcreff, Frédéric Noublanche, Sophie Noublanche, Hélène Vermersch-Leiber, Cédric Annweiler

“…Therapies using virtual or augmented reality are efficient in ecologically assessing, and eventually training, episodic memory in older populations. We designed a semi-immersive musical game called “A Life in Songs,” which invites patients to immerse themselves in a past era through visuals and songs from that time period. …”
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Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity by Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, Ignacio Juárez, Alberto Gutiérrez-Calvo, Noelia Rodríguez-Pérez, Adela Lopez, Remedios Gómez, José M. Martin-Villa

“…Methods. T cell-enriched populations of blood or tissue (tumoral and nontumoral) origin from 44 patients with gastric adenocarcinoma and 33 healthy subjects were obtained. …”
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Sidewalk thermal comfort in street canyon and role of pavements under perpendicular sun rays during summer by D. Jareemit, M. Srivanit

“…This finding carries significant importance in densely populated areas with limited natural shade, where even slight improvements in thermal comfort can have a positive effect on public health and well-being.CONCLUSION: Albedo reduction alone may not significantly enhance outdoor comfort within the street canyons. …”
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Molecular-genetic bases of plumage coloring in chicken by A. V. Makarova, O. V. Mitrofanova, A. B. Vakhrameev, N. V. Dementeva

“…In poultry including chickens, the color of the plumage can be treated as a genetic marker, useful for identifying breeds, populations and breeding groups with their specific traits. …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…In contrast, the parental MDA-MB-231 cells and other HRR proficient cell lines produced smaller cell populations with short term treatment, but with much less cumulative DNA damage, and minimal cell death. …”
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The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States by Yi Zhang, Tingzhen Li, Qixin Chen, Maobiao Shen, Xinyang Fu, Changjin Liu

“…Our research suggests that, compared with other inflammatory markers derived from complete blood cell count, MLR has the highest predictive power for the prevalence of ED and all-cause mortality in these populations.…”
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The effects of active play interventions on children’s fundamental movement skills: a systematic review by Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai

“…To better understand the potential of AP in developing FMS in children, high-quality AP interventions and more in-depth studies across diverse populations, settings, and timeframes are needed. Additionally, greater clarity is needed regarding the components of AP interventions and their quantitative relationships with FMS efficacy.…”
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Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma by Jingyuan Wang, Shuai Yan

“…We further conducted comprehensive analyses of molecular mechanisms, immune microenvironment, and drug sensitivity associated with the risk stratification.ResultsWe identified distinct histone modification patterns across five major cell populations in LGG and developed a robust 20-gene HMRS from 129 candidate genes that effectively stratified patients into high- and low-risk groups with significantly different survival outcomes (training set: AUC = 0.77, 0.73, and 0.71 for 1-, 3-, and 5-year survival; P < 0.001). …”
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Understanding the cost-utility of implementing HIV self-testing with digital-based supports by Brianna Empringham, Brianna Empringham, Angela Karellis, Marta Fernandez-Suarez, Sergio Carmona, Nitika Pant Pai, Alice Zwerling

“…Strategies to improve cost-utility include reducing testing costs, targeting key populations with increased rates of HIV test-positivity, and ensuring strong support for linkage to care.…”
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Factors Influencing Informed Consent Preferences in Digital Health Research: Survey Study of Prospective Participants by Brian J McInnis, Ramona Pindus, Daniah Kareem, Daniela G Vital, Eric B Hekler, Camille Nebeker

“…ConclusionsThe findings point toward new ways of evaluating informed consent communication: (1) for responsiveness to specific prospective participant populations, and (2) effectiveness at eliciting informed questions from people considering participation. …”
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Risk factors associated with human Mpox infection: a systematic review and meta-analysis by Nicola Luigi Bragazzi, Jianhong Wu, Jude Dzevela Kong, James Orbinski, Chigozie Louisa Jane Ugwu, Ali Asgary, Woldegebriel Assefa Woldegerima

“…Background Mpox emerged as a significant global public health concern during the 2022–2023 outbreak, impacting populations in both endemic and non-endemic countries. …”
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The simpler modified fried frailty scale predicts 2-year mortality in older adults with heart failure: a pilot study by Celalettin Küçük, Serdar Özkök, Gülistan Bahat, Ekrem Bilal Karaayvaz, Mustafa Altınkaynak, Alpay Medetalibeyoğlu, Mehmet Akif Karan

“…Its predictive validity needs to be clarified, especially in populations with a high prevalence of frailty, such as patients with heart failure (HF). …”
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The availability and distribution of health services and resources across different regions in Afghanistan by Nelly Hegazy, Sherif El Deeb, Marwa Rashad Salem, Jerome A. Shaguy, Ramesh Nassery Mohammed, Abdullah Khawari, Jamshed Tanoli, Alaa Abouzeid, Alaa Abouzeid

“…This analysis emphasises the need for targeted resource allocation and infrastructure improvements to address inequities in access to essential healthcare services, particularly for underserved populations, thereby facilitating the achievement of equitable health outcomes in Afghanistan.…”
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Molecular cytogenetic characteristics of new spring bread wheat introgressive lines resistant to stem rust by O. A. Baranova, I. G. Adonina, S. N. Sibikeev

“…Thus, highly resistant to both local populations of P. graminis and the Ug99 race, bread wheat lines are promising donors for the production of new varieties resistant to stem rust.…”
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Profiles and predictors of access to human and veterinary healthcare in multispecies households by Jennifer W. Applebaum, Courtney Dunn, Shelby E. McDonald, Kaylinn Escobar, Erin K. King, Rosalie Corona, Megan K. Mueller

“…., the Colorado “Peticaid” proposal and the Seattle One Health Clinic) to mitigate disparities and enhance healthcare and veterinary care access for vulnerable populations.…”
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Vitamin D Deficiency as a Risk Factor for Diabetic Retinopathy: A Systematic Review and Meta-Analysis by Claudia Elena Petrea, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Dorel Săndesc

“…Secondary analyses indicated that vitamin D deficiency prevalence ranged from 27% to 95% in DR populations, highlighting its potential role in disease progression. …”
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Targeted sequencing analysis pipeline for species identification of human pathogenic fungi using long-read nanopore sequencing by Nattapong Langsiri, Navaporn Worasilchai, Laszlo Irinyi, Piroon Jenjaroenpun, Thidathip Wongsurawat, Janet Jennifer Luangsa-ard, Wieland Meyer, Ariya Chindamporn

“…The ability of the method to distinguish mixed species within sub-populations of large datasets has the potential to aid computer analysis by reducing the required processing power. …”
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