MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo by Karolin Walter, Kanishka Tiwary, Marija Trajkovic-Arsic, Ana Hidalgo-Sastre, Laura Dierichs, Sven T. Liffers, Jiangning Gu, Johann Gout, Lucas-Alexander Schulte, Jan Münch, Thomas Seufferlein, Bruno Sainz, Jens T. Siveke, Eva Rodriguez-Aznar, Patrick C. Hermann

“…Herein, we use a genetically engineered mouse model of pancreatic cancer and primary pancreatic cancer cells were derived from this model to demonstrate that small-molecule MEK inhibitors functionally abrogate cancer stem cell populations as demonstrated by reduced sphere and organoid formation capacity. …”
Get full text

Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering by William S. Grubbe, Bixia Zhang, Aileen Kauffman, Fabian Byléhn, Kasia Padoł, Hae-Gwang Jung, Seung Bum Park, Jessica M. Priest, Engin Özkan, Juan J. de Pablo, T. Jake Liang, Minglei Zhao, Juan L. Mendoza

“…These findings provide a structural and functional understanding of the IFNλ4 protein and enable future comprehensive studies towards correcting IFNλ4 dysfunction in large populations of affected patients.…”
Get full text

Effect of Time and Temperature on the Detection of PRRSV RNA and Endogenous Internal Sample Control in Porcine Tongue Fluids by Isadora F. Machado, Onyekachukwu H. Osemeke, Kent Doolittle, Cesar A. A. Moura, Lucina Galina Pantoja, Giovani Trevisan, Phillip Gauger, Daniel C. L. Linhares

“…Population-based sampling has improved pathogen monitoring in the US swine industry by increasing sensitivity while reducing costs. …”
Get full text

Comparative Biotypic and Phylogenetic Profiles of Escherichia coli Isolated from Resident Stool and Lagoon in Fresco (Côte d’Ivoire) by Nadége Kouadio-Ngbesso, Koua Atobla, Paul Yao Attien, Mireille Kouame-Sina, René Ahua Koffi, Antoinette Ama Adingra, Adjehi Dadié

“…A close relationship was found between water and human strains, and the presence of commensal and extraintestinal pathogenic E. coli in all samples could represent a potential reservoir of extraintestinal infections for resident populations.…”
Get full text

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

“…The T cell compartment in the FL-PDLS preserves CD4 subsets (follicular helper, regulatory, and follicular regulatory), also encompassing the spectrum of activation/exhaustion phenotypes in CD4 and CD8 populations. Moreover, this system is suitable for chemo and immunotherapy testing, recapitulating results obtained in the clinic. …”
Get full text

Evaluating 36 years of fishing sustainability in a large reservoir by Luiz Guilherme dos Santos Ribas, Pitágoras Augusto Piana, Caroline Henn, Anderson Luís Maciel, Geuza Cantanhêde, Maurício Spagnolo Adames, Éder André Gubiani

“…Additionally, the data suggests that even 40 years after the reservoir was formed, fish populations may not yet be stable in large reservoirs.…”
Get full text

The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review by Julia Lachowska, Karolina Senior, Jerzy Smandek, Maja Mielczarek, Paulina Sroczyńska, Jan Sroczyński

“…The prevalence of AD is projected to increase significantly with aging populations. Despite the absence of a cure, early intervention during the prodromal phase can slow the progression of AD, highlighting the importance of identifying modifiable risk and protective factors. …”
Get full text

The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chines... by Ye Yuan, Yanling Tu, Yuqi Su, Lei Jin, Yu Tian, Xuesong Chang, Ke Yang, Haiyun Xu, Junyi Zheng, Daili Wu

“…It also examines possible means of implementing depression interventions in college populations through the mediating roles of self-efficacy and physical activity, and the moderating role of social support. …”
Get full text

Anatomical alterations: biparietal thinning in antiquity. Review of published cases and a new case by Nicol Rossetti, Roberta Fusco, Arianna Vanni, Francesca Garanzini, Alessandra Mazzucchi, Marta Licata

“…Cranial anatomical variations, such as biparietal thinning, offer critical insights into the health and living conditions of ancient populations. Despite the presence of extensive archaeological records, biparietal thinning remains a relatively rare and understudied condition. …”
Get full text

<i>Vibrio cholerae</i> Gut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response by Isabella Cubillejo, Kevin R. Theis, Jonathan Panzer, Xixia Luo, Shreya Banerjee, Ryan Thummel, Jeffrey H. Withey

“…<b>Background:</b> Cholera is a diarrheal disease prevalent in populations without access to clean water. Cholera is caused by <i>Vibrio cholerae,</i> which colonizes the upper small intestine in humans once ingested. …”
Get full text

Integrated malaria vector control strategies and their effectiveness in sub-Saharan Africa: a systematic review protocol for interventional studies by Diederick E Grobbee, Lihanimpo Djalogue, Marianne van der Sande, Patrice Ngangue, Gountante Kombate, Kamba Andre-Marie Soubeiga

“…Several vector control strategies are being implemented to reduce mosquito density and protect the most vulnerable populations, such as children under 5 and pregnant women. …”
Get full text

Musical Pitch Perception and Categorization in Listeners with No Musical Training Experience: Insights from Mandarin-Speaking Non-Musicians by Jie Liang, Fen Zhang, Wenshu Liu, Zilong Li, Keke Yu, Yi Ding, Ruiming Wang

“…Together, these two experiments revealed the cognitive mechanism underlying musical pitch perception in ordinary populations and provided insights into future musical pitch training strategies.…”
Get full text

Goat Genomic Resources: The Search for Genes Associated with Its Economic Traits by A. M. A. M. Zonaed Siddiki, Gous Miah, Md. Sirazul Islam, Mahadia Kumkum, Meheadi Hasan Rumi, Abdul Baten, Mohammad Alamgir Hossain

“…Several genetic characterization attempts of different goats have reported the existence of genotypic and morphological variations between different goat populations. As a result, different whole-genome sequences along with annotated gene sequences, gene function, and other genomic information of different goats are available in different databases. …”
Get full text

Challenges and strategies in meeting urban tree canopy targets: A scenario discovery analysis to guide urban forest planning in new developments by Raymundo Marcos Martinez, Natthanij Soonsawad, Mariana Dias Baptista, Stephen Cook, Guy Barnett, Joseph Chee, Tim Field, Tim Muster

“…With increasing urban populations worldwide, new developments face ambitious tree canopy cover targets to mitigate urban heat, reduce stormwater runoff, support biodiversity, and promote health benefits. …”
Get full text

<i>Naegleria fowleri:</i> Portrait of a Cerebral Killer by Nguyen The Nguyen Phung, Huong Thien Pham, Thuc Thanh Tran, Vu Hoang Dinh, Nhut Minh Tran, Nuong Ai Nguyen Tran, Minh Quang Ngoc Ngo, Huong Thanh Thi Nguyen, Duy Khanh Tran, Thao Kieu Thi Le, Camelia Quek, Van Hung Pham, Son Truong Pham

“…The geographical expansion of PAM due to climate change further underscores the urgency of these measures to improve health outcomes in vulnerable populations.…”
Get full text

Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study by Umberto Vespasiani-Gentilucci, Chiara Dell’Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi

“…Methods. Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD and healthy controls, were enrolled. …”
Get full text

Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats by Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel

“…Background/Objectives: Cocaine use disorder is an intersecting issue in populations with HIV-1, further exacerbating the clinical course of the disease and contributing to neurotoxicity and neuroinflammation. …”
Get full text

Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct... by Yunqian Guan, Xiaobo Li, Wenxiu Yu, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen

“…This suggests that the Ly6C+ cells may constitute heterogeneous populations which react differentially to the microenvironments in the infarct area. …”
Get full text

Planting Date and Seeding Rate Effects on Sunn Hemp Biomass and Nitrogen Production for a Winter Cover Crop by Kipling S. Balkcom, Jessica M. Massey, Jorge A. Mosjidis, Andrew J. Price, Stephen F. Enloe

“…Our objectives were to assess the growth of a new sunn hemp cultivar breed to produce seed in a temperate climate and determine the residual N effect on a rye (Secale cereale L.) cover crop in east-central Alabama from 2007 to 2009. Plant populations, plant height, stem diameter, biomass production, and N content were determined for two sunn hemp planting dates, following corn (Zea mays L.) and wheat (Triticum aestivum L.) harvest, across different seeding rates (17, 34, 50, and 67 kg/ha). …”
Get full text

Omega-3 Fatty Acids: Key Players in Cognitive Function and Brain Health by Wiktoria Wesołowska, Emilia Bachoń, Michalina Doligalska, Aleksandra Stremel, Agnieszka Leszyńska, Julia Linke, Zuzanna Bałoniak, Dominika Kozłowska, Julia Bałoniak, Weronika Tuszyńska

“…Their supplementation, combined with cognitively stimulating activities, offers substantial benefits, especially in aging populations. Further research is needed to fully understand omega-3s' mechanisms, optimal dosing, and their use in preventing and treating neurological disorders. …”
Get full text