Polygenic risk scores for complex diseases: where are we now? by Marie Loh, John Campbell Chambers

Get full text

Development and evaluation of patient-centred polygenic risk score reports for glaucoma screening by Georgina L Hollitt, Mark M Hassall, Owen M Siggs, Jamie E Craig, Emmanuelle Souzeau

Subjects: “…Polygenic risk scores…”
Get full text

Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch. by Rui Cao, David P Schladt, Casey Dorr, Arthur J Matas, William S Oetting, Pamala A Jacobson, Ajay Israni, Jinbo Chen, Weihua Guan

“…<h4>Methods</h4>We carried out a genome-wide scan (HLA and non-HLA regions) on AR with a large kidney transplant cohort of 784 living donor-recipient pairs of European ancestry. An AR polygenic risk score (PRS) was constructed with the non-HLA single nucleotide polymorphisms (SNPs) filtered by independence (r2 < 0.2) and P-value (< 1×10-3) criteria. …”
Get full text

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions by Shauna R. Goldberg, MPH, Linda K. Ko, PhD, Li Hsu, PhD, Hang Yin, MS, Charles Kooperberg, PhD, Ulrike Peters, PhD, MPH, Andrea N. Burnett-Hartman, PhD, MPH

Subjects: Get full text

The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort by Martin Pariès, Stéphanie Bougeard, Aida Eslami, Zhonglin Li, Michel Laviolette, Louis-Philippe Boulet, Evelyne Vigneau, Yohan Bossé

Subjects: Get full text

Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans by Mehdi Momen, Hannah K. Kearney, Margaret M. Patterson, Susannah J. Sample, Zijie Zhao, Qiongshi Lu, Guilherme J. M. Rosa, Peter Muir

“…We investigated ACL rupture heritability, genetic architecture, selection pressure, sharing of risk genes and biological pathways, and polygenic risk score (PRS) prediction of disease risk. In both species, ACL rupture has moderate heritability, is likely under negative selection, and has a highly polygenic architecture where thousands of variant effects act together to influence disease risk. …”
Get full text

Positive associations between cannabis and alcohol use polygenic risk scores and phenotypic opioid misuse among African-Americans. by Jill A Rabinowitz, Jin Jin, Sally I-Chun Kuo, Adrian I Campos, Miguel E Rentería, Andrew S Huhn, Johannes Thrul, Beth A Reboussin, Kelly Benke, Benjamin Domingue, Nicholas S Ialongo, Brion S Maher, Darlene Kertes, Vanessa Troiani, George Uhl

“…<h4>Background</h4>This study examined whether polygenic risk scores (PRS) for lifetime cannabis and alcohol use were associated with misusing opioids, and whether sex differences existed in these relations in an urban, African-American sample.…”
Get full text

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

“…Abstract Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work relatively well in South Asians, despite being derived from largely European-ancestry samples. …”
Get full text

Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study by Ying Li, Mengjiao Yang, Lu Yuan, Ting Li, Xinli Zhong, Yanying Guo

Subjects: Get full text

Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies by Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao, Emily Simmonds, Ying Wu, Niklas Mattsson-Carlgren, Oskar Hansson, Michael W. Nagle, Valentina Escott-Price, the Alzheimer’s Disease Neuroimaging Initiative

Subjects: Get full text

Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and methodology by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

Subjects: “…polygenic risk score…”
Get full text

Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study by Yidan Wang, Shan Zhong, Na Sun, Yunfei Wu, Jun Lyu, Minghui Piao, Wenbo Qu, Xueyu Wang, Wenjun Ni, Xia Gu, Tianshu Han, Jinwei Tian

Subjects: Get full text

Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

Subjects: “…Polygenic risk score…”
Get full text

The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes by Anthony Yazbeck, Reem Akika, Zainab Awada, Nathalie K. Zgheib

Subjects: Get full text

The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation... by Derek Clougher, Àlex G. Segura, Maria F. Forte, Gisela Mezquida, Manuel J. Cuesta, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Covadonga M. Díaz-Caneja, Alexandra Roldán, Giovanna Fico, Elena de la Serna, Daniel Bergé, Patricia Gassó, Natalia Rodriguez, Norma Verdolini, Alfonso Tortorella, Giulia Menculini, Marta Ribasés, Miguel Bernardo, Sergi Mas

Subjects: Get full text

Women’s preferences for testing to predict breast cancer risk – a discrete choice experiment by Yi Wang, Peh Joo Ho, Langming Mou, Jingmei Li

Subjects: Get full text

Deep learning captures the effect of epistasis in multifactorial diseases by Vladislav Perelygin, Alexey Kamelin, Alexey Kamelin, Nikita Syzrantsev, Layal Shaheen, Layal Shaheen, Anna Kim, Nikolay Plotnikov, Anna Ilinskaya, Valery Ilinsky, Alexander Rakitko, Alexander Rakitko, Maria Poptsova

Subjects: “…polygenic risk score…”
Get full text

Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer by Wen Wen, Sen Zhao, Yiwen Jiang, Chengzhu Ou, Changyuan Guo, Ziqi Jia, Jiayi Li, Yansong Huang, Hengyi Xu, Pengming Pu, Tongxuan Shang, Lin Cong, Xiang Wang, Nan Wu, Jiaqi Liu

Subjects: Get full text

Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions by Vilde Øverlien Dåstøl, Vilde Øverlien Dåstøl, Kristine Løkås Haftorn, Hamid Khoshfekr Rudsari, Piotr Pawel Jaholkowski, Piotr Pawel Jaholkowski, Ketil Størdal, Ketil Størdal, Siri Eldevik Håberg, Siri Eldevik Håberg, Clarice R. Weinberg, Lisa G. Rider, Ole A. Andreassen, Ole A. Andreassen, Ole A. Andreassen, Anne Lise Brantsæter, Ida Henriette Caspersen, Ida Henriette Caspersen, Helga Sanner, Helga Sanner

Subjects: Get full text

Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

Subjects: Get full text