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Pluripotency Factors on Their Lineage Move
Published 2016-01-01“…Interestingly, pluripotency has various shades with distinct developmental potential, an observation that coined the term of a ground state of pluripotency. …”
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Long Noncoding RNA Regulation of Pluripotency
Published 2016-01-01“…Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. …”
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Analysis of Embryoid Bodies Derived from Human Induced Pluripotent Stem Cells as a Means to Assess Pluripotency
Published 2012-01-01“…Key among numerous criteria to assess pluripotency includes the in vivo teratoma assay that has been widely proposed as a standard functional assay to demonstrate the pluripotency of hiPSCs. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine
Published 2011-01-01“…Induced pluripotent stem (iPS) cells are generated by reprogramming human somatic cells through the forced expression of several embryonic stem (ES) cell-specific transcription factors. …”
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Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP
Published 2017-01-01“…Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids
Published 2021-01-01“…With the rapid rise in gene-editing technology, pluripotent stem cells (PSCs) and their derived organoids have increasingly broader and practical applications in regenerative medicine. …”
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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
Published 2012-01-01“…They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. …”
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Patient-Specific Pluripotent Stem Cells in Neurological Diseases
Published 2011-01-01“…The increasing availability of induced pluripotent stem cells (iPSCs) derived from adult human somatic cells provides new prospects for cellreplacement strategies and disease-related basic research in a broad spectrum of human neurologic diseases. …”
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Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells
Published 2018-01-01“…Previous studies have demonstrated the ability of reprogramming endochondral bone into induced pluripotent stem (iPS) cells, but whether similar phenomenon occurs in intramembranous bone remains to be determined. …”
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Biological Effects of Culture Substrates on Human Pluripotent Stem Cells
Published 2016-01-01“…In recent years, as human pluripotent stem cells (hPSCs) have been commonly cultured in feeder-free conditions, a number of cell culture substrates have been applied or developed. …”
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Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation
Published 2019-01-01“…Moreover, phosphorylation has recently been shown to tightly control the regulatory network of kinases responsible for the induction and maintenance of pluripotency, defined as the particular ability to differentiate pluripotent stem cells (PSCs) into every cell type in the adult body. …”
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The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation
Published 2025-01-01Subjects: Get full text
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Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders
Published 2019-01-01“…Over the past decade, enormous progress has been made in the field of induced pluripotent stem cells (iPSCs). Patients’ somatic cells such as skin fibroblasts or blood cells can be used to generate disease-specific pluripotent stem cells, which have unlimited proliferation and can differentiate into all cell types of the body. …”
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Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent
Published 2016-01-01“…The inability of real adult SSCs to shift to a pluripotent state coincides with a decline in expression of the core pluripotency genes Oct4, Nanog, and Sox2 in SSCs with age. …”
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Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Published 2019-01-01“…Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome. …”
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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation
Published 2016-01-01“…Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors and mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. …”
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Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming
Published 2011-01-01“…During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. …”
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BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation
Published 2025-02-01Subjects: Get full text
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