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221
Regeneration in the absence of canonical neoblasts in an early branching flatworm
Published 2025-01-01“…Abstract The remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system. …”
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222
Supramolecular Biopolymers for Tissue Engineering
Published 2021-01-01“…These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. …”
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223
Existence of Neural Stem Cells in Mouse Spleen
Published 2019-01-01“…Pluripotent stem cells are used in regenerative medicine and exist in various internal organs. …”
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224
Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration
Published 2018-01-01“…We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.…”
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225
Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives
Published 2010-01-01“…These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. …”
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226
The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons
Published 2022-01-01“…Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. …”
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227
Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells
Published 2016-01-01“…We therefore sought to determine if a simple, one-step, and cost effective method, previously reported to induce neuronal differentiation of embryonic stem cells and induced-pluripotent stem cells, can be applied to adult stem cells. …”
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228
Research prospects for kidney xenotransplantation: a bibliometric analysis
Published 2024-12-01“…We found that ‘co-stimulation blockade’, ‘xenograft survival’, ‘pluripotent stem cell’, ‘translational research’, and ‘genetic engineering’ were likely to be the focus of attention in the coming years.Conclusions This study screened global publications related to xenogeneic kidney transplantation; analyzed their literature metrology characteristics; identified the most cited articles in the research field; understood the current situation, hot spots, and trends of global research; and provided future development directions for researchers and practitioners.…”
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229
Regenerative Medicine for Neurological Disorders
Published 2010-01-01“…Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. …”
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230
The Potential for Cellular Therapy Combined with Growth Factors in Spinal Cord Injury
Published 2012-01-01“…Research is being conducted in the following areas: pathophysiology, cellular therapies (Schwann cells, embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, olfactory ensheathing cells), growth factors (BDNF), inhibitory molecules (NG2, myelin protein), and combination therapies (cell grafts and neurotrophins, cotransplantation). …”
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231
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model
Published 2025-01-01“…We investigated gut microbiota dynamics in a nonhuman primate (NHP) cardiac ischemia/reperfusion model while under immunosuppression and receiving cell therapy with human induced pluripotent stem cell (hiPSC)-derived endothelial cells (EC) and cardiomyocytes (CM). …”
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232
Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy
Published 2025-01-01“…Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties. …”
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233
Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture
Published 2015-01-01“…In addition, hPPCs can be subcultured and exhibit expression of pluripotent genes (OCT-4, KLF-4, and NANOG) as well as a remarkable vasculogenic potential. …”
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234
The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches
Published 2024-12-01“…Epigenetic reprogramming strategies, such as induced pluripotent stem cells, may further complement senolytics by rejuvenating aged cells. …”
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235
Organoid models: applications and research advances in colorectal cancer
Published 2025-02-01“…This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. …”
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236
Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts
Published 2012-01-01“…Thus, the feasibility of substituting cMyc transgene with (non-integrative) recombinant “pTAT-mcMyc” protein delivery was assessed, without compromising reprogramming efficiency or the pluripotent phenotype. Purification and delivery of semisoluble/particulate pTAT-mcMyc maintained Oct4-GFP+ colony formation (i.e., reprogramming efficiency) whilst supporting pluripotency by various criteria. …”
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237
Drug repurposing screen for the rare disease ataxia-telangiectasia
Published 2025-01-01“…The cause of neurodegeneration due to mutations in ATM is still an area of investigation, and currently there is no known treatment to slow down or stop the progression of the neurological problems.In this collaboration of the A-T Children's Project (ATCP) with Charles River Discovery, we successfully developed a high-throughput assay using induced pluripotent stem cells (iPSC) from A-T donors to measure DNA damage response (DDR). …”
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238
Use of a Sendai virus-based vector for effcient transduction of pinniped fbroblasts
Published 2019-01-01“…Generation of induced pluripotent stem (iPS) cells expanded possibilities of pluripotency and early development studies. …”
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239
Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review
Published 2018-01-01“…Recently, advancements in pluripotent stem cells technology enable restoration of retinal functionalities after transplantation of these cells into animals with retinal degeneration. …”
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240
Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
Published 2017-01-01“…A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. …”
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