Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…This study analysed the secretomes of bone-marrow (BM.MSCs), umbilical-cord (UC.MSCs), adipose-tissue (AT.MSCs) and clinical/commercial-grade induced pluripotent stem cell-derived MSCs (iMSCs), under resting and inflammatory licenced conditions. iMSCs recapitulated the inflammatory licensing process, validating their comparability to tissue-derived MSCs. …”
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Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients by Deepa Bhartiya, Kalpana Sriraman, Seema Parte

“…We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). …”
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Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem by Karim M. Fawzy El-Sayed, Christof E. Dörfer

“…The present review summarizes the current scientific evidence on G-MSCs’ isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs’ delivery. …”
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Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Current in vitro systems of induced pluripotent stem cells (iPSCs) generated by cell reprogramming of somatic cells from patients have provided valuable disease models recapitulating key pathological molecular events. …”
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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Ioannis Papaioannou, J. Paul Simons, James S. Owen

“…This technology is applicable ex vivo, for example to target haematopoietic or induced pluripotent stem cells, and also for in vivo hepatic gene targeting. …”
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Stem Cells as In Vitro Model of Parkinson's Disease by Patricia L. Martínez-Morales, Isabel Liste

“…The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Gene circuits were transduced into induced pluripotent stem cells that were tissue-engineered into cartilage constructs. …”
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Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation by Rosaria Santoro, Gianluca Lorenzo Perrucci, Aoife Gowran, Giulio Pompilio

“…In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripotent stem cells (iPSC), since this process may strongly influence cell fate and, thus, augment the precision of differentiation into specific cell types, e.g., cardiomyocytes. …”
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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…In this review, we outline the current state of translational research involving adult stem cell and pluripotent stem cell derived intestinal organoids, highlighting the advances and limitations in disease modeling, drug-screening, personalized medicine, and stem cell therapy. …”
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Amniotic Fluid Stem Cells: Future Perspectives by Margit Rosner, Katharina Schipany, Bharanidharan Shanmugasundaram, Gert Lubec, Markus Hengstschläger

“…Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. …”
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Primordial Germ Cells: Current Knowledge and Perspectives by Aleksandar Nikolic, Vladislav Volarevic, Lyle Armstrong, Majlinda Lako, Miodrag Stojkovic

“…With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. …”
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Parthenogenesis and Human Assisted Reproduction by Adriana Bos-Mikich, Fabiana F. Bressan, Rafael R. Ruggeri, Yeda Watanabe, Flávio V. Meirelles

“…Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. …”
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Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources by Yoojin Seo, Kyung-Hwa Shin, Hyung Hoi Kim, Hyung-Sik Kim

“…In this review, we provide a general overview regarding the current strategies for generating RBCs from various stem cell sources including pluripotent stem cells (PSCs) as well as circulating blood stem cells and the remaining challenges that must be overcome prior to their practical application.…”
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Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering by Gaskon Ibarretxe, Antonia Alvarez, Maria-Luz Cañavate, Enrique Hilario, Maitane Aurrekoetxea, Fernando Unda

“…The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…This was parallel to laboratory molecular investigations of in vitro GABAergic neurons derived from induced human pluripotent stem cells (hiPSCs) of SSADHD subjects and biochemical analyses performed on a versatile murine model that uses an inducible and reversible rescue strategy allowing on-demand and cell-specific gene therapy. …”
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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. …”
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The effect of culture media and seeding densities on the human malignant testicular germ cell line (NT2/D1) growth pattern by Rawabi S. Altuwayjiri, Ibtesam S. Almami

“…The NT2/D1 cell line, a pluripotent embryonal carcinoma, is valuable in cancer and developmental biology research due to its differentiation potential into neurons and glial cells. …”
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Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy by Peter Gee, Huaigeng Xu, Akitsu Hotta

“…In the past decade, the development of two innovative technologies, namely, induced pluripotent stem cells (iPSCs) and the CRISPR Cas9 system, has enabled researchers to model diseases derived from patient cells and precisely edit DNA sequences of interest, respectively. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have already been integrated into transplantable patches and are in preclinical efforts to reverse fibrotic scarring from myocardial infarctions. …”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Bharathi Suresh, Junwon Lee, Kye-Seong Kim, Suresh Ramakrishna

“…We also discuss the possibility of using DUBs, along with core transcription factors, to efficiently generate induced pluripotent stem cells. Our review provides a relatively new understanding regarding the importance of ubiquitination/deubiquitination of stem cell transcription factors for efficient cellular reprogramming.…”
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