Time-series forest age estimation in Xinjiang based on forest disturbance and recovery detection by Lili Zhai, Mei Zan, Mao Ye, Jia Zhou, Cong Xue, Shunfa Yang, Yuntong Liu

“…Utilizing Landsat Time Series Stacked (LTSS) Data from 1991 to 2022, the LandTrendr(LT) algorithm was applied to identify forest disturbance and recovery events from 1992 to 2022 using the Google Earth Engine (GEE) platform. Finally, the forest age distribution in Xinjiang from 1991 to 2022 was mapped in conjunction with the forest disturbance events. …”
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Investigating Confined Space Asphyxias: Plastic Bag Involvement and Gas Inhalation – A Case Series and Literature Review by Sofija Saulė Kaubrytė, Sigitas Chmieliauskas, Giedrė Kažukauskė, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The accessibility of suicide-related information on online platforms contributes to the dissemination of new methods, posing challenges for suicide prevention efforts. …”
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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…The RAPID-PROTECTION trial will determine the levels of immune protection that AZD7442 offers patients at the very highest risk of SARS-CoV-2 infection and whether this protection can be further enhanced by repeated vaccination against SARS-CoV-2 virus.Methods RAPID-PROTECTION is a multicentre, interventional and open-label adaptive platform trial that aims to recruit 350 immunocompromised participants across five UK centres. …”
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Association between folate and glutamine metabolism and prognosis of kidney cancer by Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang

“…This study aimed to explore the association between folate and glutamine metabolism and prognosis of kidney cancer.MethodsWe performed expression analysis, survival analysis, genetic alteration analysis, and tumor immune infiltrate analysis of related genes using platforms such as UALCAN, GEPIA, GEPIA2, cBioPortal, and TIMER. …”
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Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation by A. Y. Tikunov, V. V. Morozov, A. N. Shvalov, A. V. Bardasheva, E. V. Shrayner, O. A. Maksimova, I. O. Voloshina, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The main method is a comparative analysis of 16S ribosomal RNA sequence libraries constructed using fecal samples obtained from patients with ulcerative colitis before and after FT and sequenced on the Illumina MiSeq platform. The obtained results showed that FT led to an increase in average biodiversity in samples after FT compared to samples before FT; however, the difference was not significant. …”
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Proteomic and serologic assessments of responses to mRNA-1273 and BNT162b2 vaccines in human recipient sera by Thomas E. Hickey, Uma Mudunuri, Heidi A. Hempel, Troy J. Kemp, Nancy V. Roche, Keyur Talsania, Brian A. Sellers, James M. Cherry, Ligia A. Pinto

“…IntroductionThe first vaccines approved against SARS-CoV-2, mRNA-1273 and BNT162b2, utilized mRNA platforms. However, little is known about the proteomic markers and pathways associated with host immune responses to mRNA vaccination. …”
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Cost Analysis for Robotic and Open Gastrectomy by Yuki Hirata, MD, PhD, Heather G. Lyu, MD, MBI, Ahad M. Azimuddin, MBA, Pamela Lu, MD, Jeeva Ajith, MBA, Jason A. Schmeisser, Elizabeth P. Ninan, MBA, Kyung Hyun Lee, PhD, Brian D. Badgwell, MD, MS, Paul Mansfield, MD, Naruhiko Ikoma, MD, MS

“…Background:. A robotic surgery platform has a high implementation cost and requires maintenance costs; however, whether the overall cost of RG, including all perioperative costs, is higher than conventional open gastrectomy (OG) remains unknown. …”
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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…The generation of TCR-like antibody and its CAR-T cells provides the state-of-the-art platform and proof-of-concept validation to broaden the scope of target antigen recognition and sheds light on the development of novel therapeutics for cancer immunotherapy.…”
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Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats by Hui-Hua Liu, Xiao-Kuo He, Hsin-Yung Chen, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Hao-Li Liu, Yung-Hsiao Chiang, Jia-Yi Wang, Xiao-Jun Feng, Ying-Zu Huang, Tsung-Hsun Hsieh

“…This newly developed tDCS animal model could be useful to further explore mechanical insights and may serve as a translational platform bridging human and animal studies, establishing new therapeutic strategies for neurological disorders.…”
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Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa by Neil H. Wood, Koketso S. Makua, Ramokone L. Lebelo, Nina Redzic, Ina Benoy, Olivier M. Vanderveken, Johannes Bogers

“…Specimens were analysed for HPV DNA on 3 separate PCR/qPCR platforms. Statistical analyses were performed for associations between the study group and categorical variables, HPV status, and data from the questionnaires. …”
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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…Additionally, the low-mechanical load nature of BFR exercise may allow for high-frequency use within residential military rehabilitation, providing a platform for conventional resistance training thereafter. …”
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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…<b>Conclusions</b>: CS-MRZ-LPX tailored formulation can potentially be regarded as a prospective nano platform to boost bioavailability and enhance pharmacodynamics efficacy. …”
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L’amphithéâtre de Reims/Durocortorum : nouveaux éléments de localisation et de datation by Pierre Mathelart

“…These architectural remains are interpreted as constituting the wall of the ancient amphitheater, on the one hand, and an esplanade surrounded by a peribolos wall, on the other. Under this platform and within its vicinity, the remains of an earlier occupation are sufficiently well preserved to reconstruct its organization. …”
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THE SOLANUM TUBEROSUM KNOWLEDGE BASE: THE SECTION ON MOLECULAR-GENETIC REGULATION OF METABOLIC PATHWAYS by T. V. Ivanisenko, O. V. Saik, P. S. Demenkov, V. K. Khlestkin, E. K. Khlestkina, N A. Kolchanov, V. А. Ivanisenko

“…SOLANUM TUBEROSUM is a computer platform for complex intellectual processing of large data bodies, including (1) automatic analysis of scientific publications and databases for extraction of information on genetics, markers, breeding, diagnostics, protection and storage technologies for potato, (2) formalized representation of extracted information in the knowledge base, (3) user access to these data, (4) analysis and visualization of query results. …”
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Intraspecific variation for heat stress tolerance in wild emmer-derived durum wheat populations by Mohammed Yousif Balla, Mohammed Yousif Balla, Nasrein Mohamed Kamal, Nasrein Mohamed Kamal, Izzat Sidahmed Ali Tahir, Izzat Sidahmed Ali Tahir, Yasir Serag Alnor Gorafi, Yasir Serag Alnor Gorafi, Modather Galal Abdeldaim Abdalla, Hisashi Tsujimoto

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Editorial by Editor

“… Dev Sanskriti: Interdisciplinary International Journal, published by Dev Sanskriti Vishwavidyalaya, Haridwar, continues its mission to serve as a platform for research on interdisciplinary subjects, particularly emphasizing the integration of indigenous ancient Indian science with modern scientific inquiry. …”
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HIV-1 resistance mutations and genetic diversity among children failing antiretroviral treatment in five healthcare facilities in Benin, West Africa. by Edwige Hermione Dagba Gbessin, Edmond Tchiakpe, René Kpemahouton Keke, Nicole Vidal, Michel Kiréopori Gomgnimbou, Haziz Sina, Euloge Senan Adjou, Aldric Afangnihoun, Moussa Bachabi, Akadiri Yessoufou, Abdoul-Salam Ouedraogo, Lamine Baba-Moussa

“…Viral loads were measured using the m2000 RealTime Abbott platform. Genotyping was carried out with the commercial Viroseq kit. …”
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The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…Thus, the antibody-M6P conjugate is highly efficient in inducing internalization and subsequent lysosome-mediated protein degradation. Our platform provides a unique method for producing biologics-based degraders that may be used to treat diseases through event-driven pharmacology, thereby addressing unmet medical needs.…”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

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