Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

“…We conducted a 16S rRNA amplicon sequencing using a nanopore-based platform, alongside routine polymerase chain reaction (PCR) testing or bacterial culture, to compare its clinical performance in pathogen detection on CSF samples. …”
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The Influence of Soil Parameters on the Impulse and Airblast Overpressure Loading above Surface-Laid and Shallow-Buried Explosives by John Q. Ehrgott Jr., Stephen A. Akers, Jon E. Windham, Denis D. Rickman, Kent T. Danielson

“…During the past several years, the US Army has focused considerable attention on developing improved methods for predicting the below-vehicle environment from these threats for use by vehicle/armor analysts; thereby, improving the survivability of these platforms. The US Army Engineer Research and Development Center recently completed the first year of a three-year effort to experimentally and numerically quantify the blast and fragment loading environments on vehicles due to surface and subsurface mine and IED detonations. …”
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Manipulating Intracellular Oxidative Conditions to Enhance Porphyrin Production in <i>Escherichia coli</i> by Bahareh Arab, Murray Moo-Young, Yilan Liu, C. Perry Chou

“…This work offers an effective platform to enhance the bio-based production of porphyrins.…”
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Analysis of Spiders’ Joint Kinematics and Driving Modes under Different Ground Conditions by Xin Hao, Wenxing Ma, Chunbao Liu, Yilei Li, Zhihui Qian, Luquan Ren, Lei Ren

“…In this study, spider locomotion was observed in detail on three pavement test platforms: horizontal hard pavement, horizontal soft pavement, and sloped soft pavement. …”
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A Novel Therapeutic Calcium Peroxide Loaded Injectable Bio-adhesive Hydrogel Against Periodontitis by Shaojie Dong, Yukun Mei, Yuwei Zhang, Wenqing Bu, Yifei Zhang, Changjie Sun, Rui Zou, Lin Niu

“…Conclusions: CP-P hydrogel can be developed as a new therapeutic platform to enhance the effectiveness of local drug administration strategy against periodontitis.…”
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Intracranial germ cell tumors: advancement in genomic diagnostics and the need for novel therapeutics by Kee Kiat Yeo, Kee Kiat Yeo, Joanna Gell, Joanna Gell, Joanna Gell, Girish Dhall, Girish Dhall, Ching Lau, Ching Lau, Ching Lau

“…Given the heterogeneity of these tumors, we highlight the challenges and controversy with these conventional approaches.ResultsWe discuss the advancements in the understanding of the underlying genetic changes in intracranial GCT and the utility of novel molecular techniques in the diagnosis and classification of intracranial germ cell tumors as well as development of potential novel therapeutics.DiscussionDevelopment of liquid biopsy platforms for diagnosis and management of malignancies is a rapidly growing field. …”
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Ultra-broadband all-optical nonlinear activation function enabled by MoTe2/optical waveguide integrated devices by Chenduan Chen, Zhan Yang, Tao Wang, Yalun Wang, Kai Gao, Jiajia Wu, Jun Wang, Jianrong Qiu, Dezhi Tan

“…The present nonlinear activator promises a general platform for three-dimensional (3D) ultra-broadband ONNs with dense integration and low activation thresholds by integrating a variety of strong nonlinear optical (NLO) materials (e.g., 2D materials) and OWGs in glass.…”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

“…We systemically screened allele-specific antisense oligonucleotides (ASOs) targeting the mutated allele to identify a potent and specific sequence using both reporter-based platforms and a patient-derived cellular model. We show that reduction of mutated GNAO1 in vitro by knockout or by ASO has a beneficial functional outcome, which can be measured by cAMP accumulation and gene expression changes. …”
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Power generation expansion planning with high penetration of geothermal energy – Potential, prospects and policy by Muhammad Amir Raza, Mahmoud Ahmad Al-Khasawneh, Yahya Z. Alharthi, Muhammad Faheem, Raza Haider, Laveet Kumar

“…Pakistan is blessed with 100 GW of geothermal capacity and it is exploited using the Low Emissions Analysis platform (LEAP) software for the study period 2024 to 2060 by taking the base year 2023. …”
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Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches by Hui Qu, Bao-dong Xie, Jian Wu, Bo Lv, Jun-bo Chuai, Jian-zhong Li, Jun Cai, Hua Wu, Shu-lin Jiang, Xiao-ping Leng, Kai Kang

“…Recently, we used 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride chemistry (EDC) to initiate a strengthened, cytokine-conjugated collagenous platform with a controlled degradation speed. In vitro, the biomaterial exhibited an enhanced mechanical strength maintaining a porous ultrastructure, and the constant release of cytokines promoted the proliferation of seeded human mesenchymal stem cells (hMSCs). …”
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Analytical Analysis of the Mechanism and Mitigation Methods of Transient Overvoltage in Direct-Drive Wind Turbine Generators Connected to Weak Power System by Xu Tian, Shengtao Wu, Luran Wei, Lixin Zhang, Nan Wang, Quan Zheng

“…Ultimately, a simulation model was developed within the PSCAD/EMTDC platform, and the accuracy of the transient overvoltage formulation was substantiated via analytical case studies. …”
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Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Conclusions: These findings suggest that the env–gag VLP mRNA platform holds significant promise for HIV-1 vaccine development.…”
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Refactoring BZIP2 on the new‐generation sunway supercomputer by Xiaohui Liu, Zekun Yin, Haodong Tian, Wubing Wan, Mengyuan Hua, Wenlai Zhao, Zhenchun Huang, Ping Gao, Fangjin Zhu, Hua Wang, Xiaohui Duan

“…This paper focuses on the design and realization of a parallelized BZIP2 algorithm tailored for deployment on the New‐Generation Sunway supercomputing platform. By leveraging the unique cache patterns of the New‐Generation Sunway processor, we propose the highly tuned multi‐threading and multi‐node implementations of the BZIP2 applications for different scenarios. …”
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The Canadian Registry for Pulmonary Fibrosis: Design and Rationale of a National Pulmonary Fibrosis Registry by Christopher J. Ryerson, Benjamin Tan, Charlene D. Fell, Hélène Manganas, Shane Shapera, Shikha Mittoo, Mohsen Sadatsafavi, Teresa To, Andrea Gershon, Jolene H. Fisher, Kerri A. Johannson, Nathan Hambly, Nasreen Khalil, Theodore K. Marras, Julie Morisset, Pearce G. Wilcox, Andrew J. Halayko, Mohammad Adil Khan, Martin Kolb

“…As the largest and most comprehensive cohort of Canadian ILD patients, CARE-PF establishes a network for future clinical research and early phase clinical trials and provides a platform for translational and basic science research.…”
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The plastid and mitochondrial genomes of <i>Vavilovia Formosa</i> (Stev.) Fed. and the phylogeny of related legume genera by N. V. Shatskaya, V. S. Bogdanova, O. E. Kosterin, G. V. Vasiliev, A. K. Kimeklis, E. E. Andronov, N. A. Provorov

“…Fed. were assembled on the base of the data of high-throughput sequencing of DNA isolated from a sample from North Osetia, Russia, using Illumina and PacBio platforms. The long PacBio reads were sufficient for reliable assembling organellar genomes while the short Illumina reads obtained from total DNA were unacceptable for this purpose because of substantial contamination by nuclear sequences. …”
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Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population by Yan Su, Yuan Feng, Xinran Lin, Chunyang Ma, Jiali Wei

“…Four candidate loci were identified using the MassARRAY platform. Logistic regression analysis was employed to assess the association between TERT gene variants and the risk of CKD. …”
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Genome assembly of <i>Vitis rotundifolia</i> Michx. using third-generation sequencing (Oxford Nanopore Technologies) by M. M. Agakhanov, E. A. Grigoreva, E. K. Potokina, P. S. Ulianich, Y. V. Ukhatova

“…Third-generation sequencing on the MinION platform was performed to obtain information on the primary structure of the cultivar’s genomic DNA, employing also the results of Illumina sequencing available in databases. …”
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Dynamic changes of extracellular vesicles during zebrafish organogenesis by Linda-Marie Mulzer, Tim Felger, Luis E. Muñoz, Gesa Engl, Heiko Reutter, Mario Schiffer, Leila Pourtalebi Jahromi, Fanni Annamária Boros, Friederike Zunke, Philipp Arnold, Alina C. Hilger

“…Since EVs serve as cargo delivery platforms, the increase in size of sEVs may reflect the need for a higher transport capacity.…”
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Improving wind and power predictions via four-dimensional data assimilation in the WRF model: case study of storms in February 2022 at Belgian offshore wind farms by T. Ivanova, T. Ivanova, S. Porchetta, S. Porchetta, S. Buckingham, G. Glabeke, G. Glabeke, J. van Beeck, W. Munters

“…Our findings indicate that assimilating wind observations significantly reduces the relative root-mean-square error for wind speed at a wind farm located 47 km downwind from the offshore lidar platform. This leads to more accurate power production outputs. …”
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Development and Characterization of Lyophilized Chondroitin Sulfate-Loaded Solid Lipid Nanoparticles: Encapsulation Efficiency and Stability by Marta E. Bustos Araya, Anna Nardi Ricart, Ana C. Calpena Campmany, Rafel Prohens, Montserrat Miñarro Carmona

“…This study explores the development and characterization of lyophilized chondroitin sulfate (CHON)-loaded solid lipid nanoparticles (SLN) as an innovative platform for advanced drug delivery. <b>Background/Objectives:</b> Solid lipid nanoparticles are increasingly recognized for their biocompatibility, their ability to encapsulate diverse compounds, their capacity to enhance drug stability, their bioavailability, and their therapeutic efficacy. …”
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