Health and economic cost estimates of short-term total and wildfire PM2.5 exposure on work loss: using the consecutive California Health Interview Survey (CHIS) data 2015–2018 by Michael Jerrett, Yu Yu, Ying-Ying Meng, Diane Garcia-Gonzales, Mohammad Z Al-Hamdan, Miriam E Marlier, Joseph L Wilkins, Ninez Ponce

“…We calculated and applied the coefficient for the association between daily PM2.5 exposure and work loss from regression analyses to the Environmental Benefits Mapping and Analysis Program—Community Edition (BenMAP-CE) platform to assess the health and economic impacts of PM2.5 exposure on work loss due to sickness.Results We observed that each 1 µg/m3 increase in daily total PM2.5 exposure will lead to about 1 million days of work loss per year ranging from 1.1 to 1.6 million person-days, and the related economic loss was $310–390 million. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…Here, we identify a cancer cell-intrinsic mechanism that contributes to a T cell-resistant phenotype and describes potential combinatorial therapy.Methods We used an unbiased screening approach of T cell resistant and sensitive murine KPC (KrasLSL-G12D/+; Trp53fl/fl; Ptf1aCre/+) PDAC cells in a three-dimensional co-culture platform with syngeneic antigen-educated T cells to identify potential cell-intrinsic drivers of T cell suppression in PDAC. …”
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Digital Twin Technology in Resolving Polycystic Ovary Syndrome and Improving Metabolic Health: A Comprehensive Case Study by Paramesh Shamanna, MD, Anuj Maheshwari, MD, Ashok Keshavamurthy, MD, Sanjay Bhat, DM, Abhijit Kulkarni, DM, Shivakumar R, MD, Kumar K, MD, Mukulesh Gupta, MD, Mohamed Thajudeen, MD, Ranjita Kulkarni, MD, Shashikiran Patil, MD, Shashank Joshi, DM

“…She was enrolled in the Digital Twin (DT) platform, which uses artificial intelligence and Internet of Things to deliver personalized nutrition by predicting postprandial glucose responses and suggesting alternative foods with lower postprandial glucose response through a mobile app. …”
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Application of metagenomic next-generation sequencing in the diagnosis of post-stroke infections: a case series study using multiple sample types by Xiaopu Chen, Yong Liang, Wei Yang, Wenzhen He, Zhiqiang Xing, Shunxian Li, Shaoyu Cai, Jiping Fu, Xiaotang Peng, Manli Chen, Jiaming Wu

“…Additionally, we evaluated the performance differences among various sequencing platforms.ResultsAmong the 18 stroke patients enrolled, pulmonary infections were identified in 7 cases, urinary tract infections in 1 case, central nervous system infections in 10 cases, and combined pulmonary and central nervous system infections in 2 cases, with 2 cases yielding negative results. mNGS detected pathogens in 13 cases, aligning with clinical diagnoses (75% concordance), whereas culture-based methods yielded positive results in only 6 cases (22% concordance). …”
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Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis by Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin

“…Seven electronic databases and three clinical trial registry platforms were searched. Data from the eligible studies were combined to calculate pooled risk ratios or standardized mean differences, and some included studies are presented in a narrative synthesis.ResultsForty studies with 196 DMD participants were included in the analysis. …”
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mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae by Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao

“…This study provides a novel vaccine strategy against K. pneumoniae and a potent platform to elicit high levels of humoral and cell-meditated immunity.…”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…RNA extracted from mouse lung tissues was sequenced on the Illumina Novaseq platform. Results A severe lung injury model after irradiation was built based on pre-existing ILD mice induced by BLM administration. …”
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Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta‐Analysis of Randomized Controlled Trials by Zhaokai Jin, Yi Tang, Hua Huang, Lei Chen, Zhongyi Zhang, Tianyou Ma, Zhengming Wang, Hai Su, Haojing Zhou, Shuaijie Lv, Peijian Tong

“…Methods A comprehensive search of five databases and two clinical trial registration platforms was conducted from inception through March 31, 2024, and conducted to identify eligible randomized controlled trials (RCTs). …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…Metabolite fingerprinting was carried out by flow infusion electrospray ionisation high-resolution mass spectrometry and metabolomic data were analysed using the R-based platform MetaboAnalyst. The metabolites were identified using DIMEdb (dimedb.ibers.aber.ac.uk) from their mass/charge ratios. …”
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The Middle to Late Triassic of Central Saudi Arabia with emphasis on the Jilh Formation. Part I: lithostratigraphy, facies and paleoenvironments, palaeontology and biostratigraphic... by Le Nindre, Yves-Michel, Vaslet, Denis, Vrielynck, Bruno, Krystyn, Leopold, Manivit, Jacques, Memesh, Abdullah, Davies, Roger Brett

“…Instead, new identifications of Middle and Late Triassic conodonts in the formation and at the base of the overlying Minjur Sandstone/Formation, allied to re-interpretation of previously described ammonoids, provide new paleogeographic and chronostratigraphic data, which improve our understanding of transgressive–regressive (T–R) sequences at the outcrop and platform scales and demonstrate that the lithostratigraphic units of the Jilh Formation were inconsistently recognized at outcrop north of 25°30$^{\prime }$N due to erosion by a fourth unit of early Alaunian (Middle Norian) age; this raises the issue of the Jilh–Minjur boundary addressed in Part II. …”
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Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…HA2, the neck of the HA protein, and M2e, the extracellular N-terminal structural domain of the M2 protein, are conserved and effective protective antigens.In this study, the HA2 sequences were fused with three M2e copies (H9N2, H1N1 and H5N1) to the norovirus VP1 protein via the SpyTag-SpyCatcher platform to form self-assembled nanoparticles and display antigenic proteins on its surface, yielding pYL262. …”
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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…The present study intends to pilot a combined multidisciplinary, online screening platform and general practitioner (GP) shared care neurodevelopmental follow-up model to determine feasibility of a larger, future study. …”
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Development and evaluation of optimized PCR and indirect ELISA for the detection of Morganella morganii in dairy cows by Meihua Zhang, Jiayi Li, Jianfeng Xue, Huiling Xu, Muzi Li, Yibo Xia, Changxi Qi, Pu Zhang, Yongxia Liu, Jianzhu Liu

“…The PCR technique’s efficiency and sensitivity make it ideal for pathogen detection in fecal samples, while the I-ELISA method provides a robust platform for serological analysis. Together, these tools enable timely intervention, contributing to improved livestock health management and mitigating the negative impacts of M. morganii on dairy cow productivity. …”
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Failure of Value Co-creation; Co-destruction of Brand Value in Social Media by Ghazale Taheri, Azim Zarei, Davood Feiz, Mehdi Dehghani soltani

“…Objective With the increase in the use of social media platforms by customers to buy products and services of brands, the importance of interactions between companies and customers to improve the value of brands has increased. …”
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Developing a Prototype Machine Learning Model to Predict Quality of Life Measures in People Living With HIV by Mercadal-Orfila G, Serrano López de las Hazas J, Riera-Jaume M, Herrera-Perez S

“…Furthermore, leveraging platforms like NAVETA for deploying these models presents a scalable approach to implementation, fostering patient-centered, value-based care.Keywords: machine-learning in healthcare, PROMs-PREMs, chronic HIV management, evidence-based medicine, NAVETA…”
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Designing and Modeling Digital Transformation in the Automotive Industry: Leveraging the Fourth Industrial Revolution by Mohammad Saeed Mozafari Mehr, Mohammad Taghi Taghavifard

“…The fourth industrial revolution provides the necessary platform and the competitiveness of Iran Khodro plays an intervening role. …”
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Comparing Deep Learning models for mapping rice cultivation area in Bhutan using high-resolution satellite imagery by Biplov Bhandari, Timothy Mayer

“…Two Deep Learning approaches, point-based (DNN) and patch-based (U-Net), models were used in conjunction with cloud-computing platforms. Four different models per Deep Learning approaches (DNN and U-Net) were trained: (1) Red, Green, Blue, and Near-Infrared (RGBN) channels from Planet, (2) RGBN and Elevation data (RGBNE), (3) RGBN and Sentinel-1 data (RGBNS), and (4) RGBN with Elevation and Sentinel-1 data (RGBNES). …”
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Identifying Touchpoints for Foreign Tourists in the Customer Journey through 5 A's Approach by Mostafa Esmaeili Mahyari, Mohammad Ghaffari, Hamid Reza Irani, Elham Ebrahimi

“…Additionally, brand advocates active on social media platforms play a critical role in influencing potential tourists' decisions to travel to Iran by sharing their experiences and reacting to negative reviews.…”
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Digital Mindfulness Training for Burnout Reduction in Physicians: Clinician-Driven Approach by Lia Antico, Judson Brewer

“…In the first study, 27 physicians received the digital MT in a podcast format, while in the second study, 29 physicians and nurse practitioners accessed the same training through a free app-based platform. The main outcome measure was cynicism, one dimension of burnout. …”
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Assessing the visibility and public engagement of bone marrow and stem cell transplantation research: An altmetric analysis by Mohammad Ahmadian, Shaban Alizadeh, Azadeh Omidkhoda, Fatemeh Sheikhshoaei, Brenda Van Wyk

“…Conclusion: A high percentage of articles in this field are present on social networks and platforms. Furthermore, highly cited articles on social media have attracted more attention. …”
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