Cost Analysis for Robotic and Open Gastrectomy by Yuki Hirata, MD, PhD, Heather G. Lyu, MD, MBI, Ahad M. Azimuddin, MBA, Pamela Lu, MD, Jeeva Ajith, MBA, Jason A. Schmeisser, Elizabeth P. Ninan, MBA, Kyung Hyun Lee, PhD, Brian D. Badgwell, MD, MS, Paul Mansfield, MD, Naruhiko Ikoma, MD, MS

“…Background:. A robotic surgery platform has a high implementation cost and requires maintenance costs; however, whether the overall cost of RG, including all perioperative costs, is higher than conventional open gastrectomy (OG) remains unknown. …”
Get full text

Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…The generation of TCR-like antibody and its CAR-T cells provides the state-of-the-art platform and proof-of-concept validation to broaden the scope of target antigen recognition and sheds light on the development of novel therapeutics for cancer immunotherapy.…”
Get full text

Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats by Hui-Hua Liu, Xiao-Kuo He, Hsin-Yung Chen, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Hao-Li Liu, Yung-Hsiao Chiang, Jia-Yi Wang, Xiao-Jun Feng, Ying-Zu Huang, Tsung-Hsun Hsieh

“…This newly developed tDCS animal model could be useful to further explore mechanical insights and may serve as a translational platform bridging human and animal studies, establishing new therapeutic strategies for neurological disorders.…”
Get full text

Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa by Neil H. Wood, Koketso S. Makua, Ramokone L. Lebelo, Nina Redzic, Ina Benoy, Olivier M. Vanderveken, Johannes Bogers

“…Specimens were analysed for HPV DNA on 3 separate PCR/qPCR platforms. Statistical analyses were performed for associations between the study group and categorical variables, HPV status, and data from the questionnaires. …”
Get full text

How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…Additionally, the low-mechanical load nature of BFR exercise may allow for high-frequency use within residential military rehabilitation, providing a platform for conventional resistance training thereafter. …”
Get full text

Virtual Integration of Satellite and In-situ Observation Networks (VISION) v1.0: In-Situ Observations Simulator (ISO_simulator) by M. R. Russo, M. R. Russo, S. L. Bartholomew, S. L. Bartholomew, D. Hassell, D. Hassell, A. M. Mason, E. Neininger, A. J. Perman, D. A. J. Sproson, D. Watson-Parris, D. Watson-Parris, N. L. Abraham, N. L. Abraham

“…This arises from differences in spatial and temporal sampling between models and observational platforms: observational data from a research aircraft, for example, are sampled on specified flight trajectories at very high temporal resolution. …”
Get full text

Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…<b>Conclusions</b>: CS-MRZ-LPX tailored formulation can potentially be regarded as a prospective nano platform to boost bioavailability and enhance pharmacodynamics efficacy. …”
Get full text

L’amphithéâtre de Reims/Durocortorum : nouveaux éléments de localisation et de datation by Pierre Mathelart

“…These architectural remains are interpreted as constituting the wall of the ancient amphitheater, on the one hand, and an esplanade surrounded by a peribolos wall, on the other. Under this platform and within its vicinity, the remains of an earlier occupation are sufficiently well preserved to reconstruct its organization. …”
Get full text

THE SOLANUM TUBEROSUM KNOWLEDGE BASE: THE SECTION ON MOLECULAR-GENETIC REGULATION OF METABOLIC PATHWAYS by T. V. Ivanisenko, O. V. Saik, P. S. Demenkov, V. K. Khlestkin, E. K. Khlestkina, N A. Kolchanov, V. А. Ivanisenko

“…SOLANUM TUBEROSUM is a computer platform for complex intellectual processing of large data bodies, including (1) automatic analysis of scientific publications and databases for extraction of information on genetics, markers, breeding, diagnostics, protection and storage technologies for potato, (2) formalized representation of extracted information in the knowledge base, (3) user access to these data, (4) analysis and visualization of query results. …”
Get full text

Intraspecific variation for heat stress tolerance in wild emmer-derived durum wheat populations by Mohammed Yousif Balla, Mohammed Yousif Balla, Nasrein Mohamed Kamal, Nasrein Mohamed Kamal, Izzat Sidahmed Ali Tahir, Izzat Sidahmed Ali Tahir, Yasir Serag Alnor Gorafi, Yasir Serag Alnor Gorafi, Modather Galal Abdeldaim Abdalla, Hisashi Tsujimoto

Get full text

Editorial by Editor

“… Dev Sanskriti: Interdisciplinary International Journal, published by Dev Sanskriti Vishwavidyalaya, Haridwar, continues its mission to serve as a platform for research on interdisciplinary subjects, particularly emphasizing the integration of indigenous ancient Indian science with modern scientific inquiry. …”
Get full text

Acceptance, Safety, and Effect Sizes in Online Dialectical Behavior Therapy for Borderline Personality Disorder: Interventional Pilot Study by Ruben Vonderlin, Tali Boritz, Carola Claus, Büsra Senyüz, Saskia Mahalingam, Rachel Tennenhouse, Stefanie Lis, Christian Schmahl, Jürgen Margraf, Tobias Teismann, Nikolaus Kleindienst, Shelley McMain, Martin Bohus

“… BackgroundThe potential of telehealth psychotherapy (ie, the online delivery of treatment via a video web-based platform) is gaining increased attention. However, there is skepticism about its acceptance, safety, and efficacy for patients with high emotional and behavioral dysregulation. …”
Get full text

HIV-1 resistance mutations and genetic diversity among children failing antiretroviral treatment in five healthcare facilities in Benin, West Africa. by Edwige Hermione Dagba Gbessin, Edmond Tchiakpe, René Kpemahouton Keke, Nicole Vidal, Michel Kiréopori Gomgnimbou, Haziz Sina, Euloge Senan Adjou, Aldric Afangnihoun, Moussa Bachabi, Akadiri Yessoufou, Abdoul-Salam Ouedraogo, Lamine Baba-Moussa

“…Viral loads were measured using the m2000 RealTime Abbott platform. Genotyping was carried out with the commercial Viroseq kit. …”
Get full text

The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

Get full text

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…Thus, the antibody-M6P conjugate is highly efficient in inducing internalization and subsequent lysosome-mediated protein degradation. Our platform provides a unique method for producing biologics-based degraders that may be used to treat diseases through event-driven pharmacology, thereby addressing unmet medical needs.…”
Get full text

A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

Get full text

Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…ObjectiveTo explore the mechanism of <italic>Coptis chinensis</italic> in the treatment of type 2 diabetes mellitus based on network pharmacology and molecular docking.MethodsThe active chemical ingredients of <italic>Coptis chinensis</italic> were screened through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), oral bioavailability (OB) ≥30% and drug-likeness (DL) ≥0.18 were set. …”
Get full text

Impact of COVID-19 on rheumatic diseases in india: Determinants of mortality and adverse outcome: A retrospective, cross-sectional cohort study by Avinash Jain, Vineeta Shobha, S Chandrashekara, Padmanabha Shenoy, Sapan C Pandya, Prakash Chotalia, Sharath Kumar, Sourabh Malviya, Yogesh Preet Singh, Abhishek Patil, Vikas Gupta, Puja Srivastava, Vijaya Prasanna Parimi, Chanakya Kodishala, Ramya Janardana, Benzeeta Pinto, Sudhir Bhandari, Govind Rankawat, Praveen Pratap Jadhav, Damodaram Potugari, Vishnu Sharma, Alpana Parmar, Sunitha Kayidhi, Paul T Antony, Ashish Badika, Amit Sharma

“…Methods: All registered members of IRA were invited to participate in this registry and provide information of reverse transcription–polymerase chain reaction confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected RD patients using an online platform https://iradatabaseard.in/iracovid/index.php. …”
Get full text

Educating the digital generation: the role of virtual communities by E. M. Kharlanova, N. V. Sivrikova, S. V. Roslyakova, E. G. Chernikova

“…One of them is virtual communities, i.e. communities existing on the platforms of digital resources, using digital devices, information and communication technologies. …”
Get full text

Digital Information Exchange Between the Public and Researchers in Health Studies: Scoping Review by Nazli Soltani, Thilo Dietz, Doris Ochterbeck, Jens Dierkes, Katja Restel, Lara Christianson, Karina Karolina De Santis, Hajo Zeeb

“…The digital information exchange methods included websites, emails, forums, platforms, social media, and portals. Interactivity (ie, if digital information exchange is or should be active or passive) was addressed in half of the studies. …”
Get full text