Multicomponent rehabilitation to improve independence and functioning in elderly patients with common age-associated diseases: a scoping review by Omar Baritello, Hanna Stein, Heinz Völler, Annett Salzwedel, Theo Taxis, Machteld Luizink-Dogan

“…This review mapped the evidence on MR in elderly patients following hospitalisation for age-related conditions regarding functioning-related outcomes.Design Scoping review.Data sources PubMed, Cochrane Library, International Clinical Trials Registry Platform and ClinicalTrials.gov (searched through 24 June 2024).Eligibility criteria We included randomised controlled trials (RCT) and controlled cohort studies (CCS) comparing centre-based MR with usual care (medical care excluding exercise training) in patients ≥75 years, hospitalised for age-related cardiac, neurological, oncological and orthopaedic diseases. …”
Get full text

Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…Objective:To explore the mechanism of intervention of Hedyotis diffusa on osteosarcoma by network pharmacology and molecular docking.Methods:The active components and related targets of Hedyotis diffusa were predicted through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), while, osteosarcoma-related genes were obtained through Gene Expression Omnibus database. …”
Get full text

The Risk of Escalating Cyberattacks and Financial Fraud During Wartime: The Maturity of The County's Judicial System in Combating Cyber and Financial Crimes by Hanna Yarovenko, Iryna Pozovna, Roman Bylbas

“…The rapid digitalization of financial systems and public services during the war has expanded attack surfaces, with cybercriminals exploiting vulnerabilities in digital banking platforms and cryptocurrency transactions. While judicial efficiency has shown improvement in prosecuting certain offenses, the overall maturity of the system remains inconsistent, reflecting gaps in enforcement and resource allocation. …”
Get full text

A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…Peer-to-peer learning delivered across a variety of platforms, to share experiences of gene therapy and contextualise more ‘formal’ gene therapy education, was considered invaluable.…”
Get full text

Distribution Characteristics and Coupling Relationship Between Soil Erosion and Hydrologic and Sediment Connectivity in Changchong River Basin by LI Jianing, ZHANG Hongli, TIAN Changyuan, ZHANG Yi, ZHA Tonggang

“…[Methods] By using the RUSLE model and introducing the connectivity index (IC) and topographic humidity index (TWI), the distribution characteristics of soil erosion, hydrological and sediment connectivity in the Changchong River Basin in 2021 were quantitatively evaluated by GIS platform. The effects of different slope, land use, elevation and slope direction on soil erosion intensity and hydrologic and sediment connectivity in small catchments were discussed, and the coupling relationship between soil erosion and hydrologic and sediment connectivity was analyzed through spatial autocorrelation. …”
Get full text

Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy by Darwish A, Sándor N, Szenti I, Marosvölgyi T, Juhász K, Rónavári A, Kachal E, Kutus B, Kónya Z, Balogi Z

“…Finally, applying the most stable lipid composition, PC/PG/SM-LAg-c, and in part PC/PG/SM-LAg-u effectively inhibited a tissue-like invasion of melanoma spheroids.Conclusion: Altogether, highly stable purified LAg formulations were created, which effectively block survival, clonogenic potential and invasion of melanoma cells, therefore could be promising NP platforms for targeted tumor therapy.Keywords: silver nanoparticle, liposome, encapsulation, tumor cell viability, tumor spheroid invasion…”
Get full text

Evaluation of Real-World Evidence to Assess Effectiveness Outcomes of Janus Kinase Inhibitors for Rheumatoid Arthritis: A Systematic Review of US Studies by Gandy C, Bazzazzadehgan S, Bruera S, Huang Y

“…All citations were imported into COVIDENCE platform. Two reviewers independently performed title/abstract screening and full-text eligibility. …”
Get full text

Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease by Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang

“…The correlation between the screened genes and PD was evaluated with the online tool Comparative Toxicogenomics Database (CTD), and protein-protein interaction (PPI) networks were built by the STRING platform. We further investigated the expression of genes in the miRNA-mRNA regulatory network in blood samples collected from PD patients and healthy donors via qRT-PCR. …”
Get full text

Bacterial community profiling and identification of bacteria with lignin-degrading potential in different gut segments of African palm weevil larvae (Rhynchophorus phoenicis) by Jessica Lenka, Jessica Lenka, Enrique González-Tortuero, Shweta Kuba, Natalie Ferry

“…Bacterial metagenomic DNA was extracted from the foregut, midgut, and hindgut of larvae of the APW, and the V3–V4 hypervariable region of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The generated data were analysed and taxonomically classified to identify the different bacterial phylotypes within the gut community cumulatively and per gut segment. …”
Get full text

Establishment and characterization of a new mouse gastric carcinoma cell line, MCC by Yushen Wang, Xianju Li, Yi Wang, Jun Qin

“…Conclusions The MCC cell line serves as an indispensable model for gastric cancer research, offering a robust platform for investigating tumor development and progression. …”
Get full text

The Relationship between Russian Identity and Political Polarization: The Role of Secure National Identification and National Narcissism by O.A. Gulevich, S.S. Kosimova

“…Respondents participated in an online survey conducted in Yandex Toloka platform (sample 1) and Anketolog (sample 2). The study involved two measurements: the first was conducted in 2023, and the second in 2024. …”
Get full text

Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

“…Methods Utilizing The Cancer Genome Atlas database, and other publicly accessible platforms, we comprehensively analyzed SETD4 gene expression, methylation patterns, and prognostic significance. …”
Get full text

Developing a method for root-zone soil moisture monitoring at the field scale using remote sensing and simulation modeling by Hamideh Noory, Morteza Khoshsima, Atsushi Tsunekawa, Mitsuru Tsubo, Nigussie Haregeweyn, Salar Pashapour

Get full text

How Authoritative Media and Personal Social Media Influence Policy Compliance Through Trust in Government and Risk Perception: Quantitative Cross-Sectional Survey Study by Hua Zhang, Cheng Yang, Xiuxian Deng, Chunyan Luo

“…Media use, specifically the use of authoritative media and “we-media,” that is, personal social media accounts and media platforms operated by individuals, was set as the independent variable. …”
Get full text

Gender Preferences in Healthcare: A Study of Saudi Patients&rsquo; Physician Preferences by Alhomayani KM, Bukhary HA, Aljuaid FI, Alotaibi TA, Alqurashi FS, Althobaiti KN, Althobaiti NS, Althomali OY, Althobaiti AA, Aljuaid MM, Muhyei AM

“…The study was conducted across various regions of Saudi Arabia, with participants recruited via social media platforms using convenience sampling aged 18 years and older who were actively pursuing medical care. …”
Get full text

Study protocol for COVID-19 breakthrough infections and vaccine-induced immune response among a cohort of healthcare workers, Bangladesh. by Md Zakiul Hassan, Ahamed Khairul Basher, Mohammed Ziaur Rahman, Taufiqur Rahman Bhuiyan, Fahmida Chowdhury, Md Kamal Hossain, Aninda Rahman, Md Nazmul Islam, Lindsey M Duca, Susan Cornelia Kaydos-Daniels, Benjamin A Dahl, Firdausi Qadri, Nancy Ortiz

“…We will use the EUROIMMUN kit and will also perform in-house ELISA to assess host immune factors with Luminex platform.<h4>Discussion</h4>This proposed study will generate useful data on COVID-19 breakthrough infection and the durability of anti-SARS-CoV-2 antibodies among HCWs following vaccination. …”
Get full text

The Exposure Assessment in Current Time Study: Implementation, Feasibility, and Acceptability of Real-Time Data Collection in a Community Cohort of Illicit Drug Users by Gregory D. Kirk, Beth S. Linas, Ryan P. Westergaard, Damani Piggott, Robert C. Bollinger, Larry W. Chang, Andrew Genz

“…Hand-held electronic diaries used in the initial trials were transitioned to a smartphone platform for the final trial with identical data collection. …”
Get full text

Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Summary statistics for plasma proteins were obtained from genome-wide association studies performed using SomaLogic (N = 35,559; deCODE) and Olink (N = 34,557; UK Biobank; UKB) proteomic platforms and for MM risk from a meta-analysis of UKB and FinnGen (case = 1649; control = 727,247) or FinnGen only (case = 1085; control = 271,463). …”
Get full text

Exploring barriers to early breast examination and screening among Arab women in the MENA region: A KAP study by Ehsan Qtaishat, Reem Al-Ajlouni, Khawlah Ammar, Mohammed Liswi, Abdallah Al-Ani, Rasha Fakheraldeen, Shorouq Al-hasson

“…The survey was distributed over social media platforms during the period between June 2022–September 2022. …”
Get full text

European ILD registry algorithm for self-assessment in interstitial lung diseases (eurILDreg ASA-ILD). by Ekaterina Krauss, Laurenz H Claas, Silke Tello, Jennifer Naumann, Sandra Wobisch, Stefan Kuhn, Raphael W Majeed, Karen Moor, Maria Molina-Molina, Oisin Byrne, Rebecca Borton, Marlies S Wijsenbeek, Nik Hirani, Carlo Vancheri, Bruno Crestani, Andreas Guenther, eurILDreg investigators

“…This ASA-ILD algorithm is integrated into the patientMpower Ltd. smartphone application, used for patient-led monitoring, research, and clinical care since 2016, and available on both Apple and Android platforms.<h4>Discussion</h4>For patient-centered measurements, participants in the multicenter eurILDreg study will receive a patientMpower account, a handheld clinical-grade spirometer (Spirobank Smart, MIR, Italy), and a pulse oximeter (Nonin Medical, Inc. …”
Get full text