PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Methods After thoroughly evaluating the gene expression and signaling patterns characterizing ACC, we applied PandaOmics (an AI-driven software platform for novel therapeutic target discovery) on the unique transcriptomic dataset of 87 primary ACCs. …”
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Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol by Yue Wang, Xin Li, Ying Wang, Hongmei Zhao, Qian Lu, Yujie Zhou, Liyuan Zhang, Aomei Shen, Jingru Bian, Wanmin Qiang, Jingming Ye, Hongmeng Zhao, Yubei Huang, Zhongning Zhang, Peipei Wu

“…Data collection, storage and management were conducted using the online ‘H6WORLD’ data management platform. Survival analysis using the Kaplan-Meier estimate will determine the incidence of BCRL. …”
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Questionnaire survey on the clinical application of Hall technique preformed metal crowns in caries of primary molars in China by Junhui Wang, Baize Zhang, Yujiang Chen, Lulu Wang, Yang Du, Xin Ge, Fen Liu, Fen Liu, Jing Gong, Jing Gong, Xiaojing Wang

“…ObjectiveTo analyze the clinical application and limiting factors of the Hall technique (HT) preformed metal crowns in caries of primary molars and to provide reference for its clinical application based on a questionnaire survey.Materials and methodsFrom June to December 2022, a questionnaire was distributed to pediatric dentists through the WeChat platform using “Questionnaire Star” to analyze the clinical application and influencing factors of the HT preformed metal crowns in caries of primary molars.ResultsA total of 700 survey questionnaires were distributed, and 650 valid questionnaires were recovered, with a effectiveness rate of 92.86%. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…The main source of Salmonella for humans is animal-borne foods; however, the monitoring of Salmonella in the food chain via genomic platforms was limited in China. This study evaluated the prevalence, resistome, and virulome diversity of Salmonella strains identified from pork, retail environment, aquatic products, and poultry eggs of retail markets in Yichun city, Jiangxi province. …”
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Novel biomarkers: the RUNX family as prognostic predictors in colorectal cancer by Yingting Liu, Yingting Liu, Yingting Liu, Junjun Chen, Junjun Chen, Junjun Chen, An Li, An Li, An Li, Yue Wu, Yue Wu, Yue Wu, Junwei Ge, Junwei Ge, Junwei Ge, Maoling Yuan, Maoling Yuan, Maoling Yuan, Bin Xu, Bin Xu, Bin Xu, Xiao Zheng, Xiao Zheng, Xiao Zheng, Lujun Chen, Lujun Chen, Lujun Chen, Jingting Jiang, Jingting Jiang, Jingting Jiang

“…Moreover, further bioinformatic analysis conducted utilizing the TISIDB and TIMER platforms demonstrated significant associations between the members of the RUNX family and immune-infiltrating cells, specifically diverse subpopulations of CD8+TILs. …”
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Spatio-temporal Evolution of Land Surface Temperature and Its Response to LULC in the Urban Agglomeration of Central Yunnan by LIN Zhiqiang, PENG Shuangyun, SHI Shuangfu, HUANG Bangmei, MA Dongling, ZHU Ziyi, MA Xiaoliang, GONG Luping

“…[Methods] Based on Google Earth Engine (GEE) platform, LST was inverted using Landsat satellite image data of central Yunnan urban agglomeration region from 1990 to 2020, and was analyzed using Sen-MK trend analysis, mean-standard deviation method, urban thermal field variance index (UTFVI) and correlation analysis were used to quantitatively analyze the spatial and temporal variations of LST and its response to LULC types in central Yunnan urban agglomeration from 1990 to 2020. …”
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The Impact of Social Media for Hand Surgeons: A Prevalence and Correlation Study With Online and Academic Reputations by Sameer R. Khawaja, BS, Krishna N. Chopra, MA, Musab Gulzar, BS, Ozair R. Khawaja, HS, Shammah E. Udoudo, BS, Joseph G. Monir, MD, Michael B. Gottschalk, MD, Adrian L. Huang, MD, Nina Suh, MD, Eric R. Wagner, MD, MS

“…Each name was searched on various social media platforms. Average ratings, number of reviews, and number of comments were collected from Healthgrades, Google reviews, and Vitals. …”
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The Role of Extracts of Edible Parts and Production Wastes of Globe Artichoke (<i>Cynara cardunculus</i> L. var. <i>scolymus</i> (L.)) in Counteracting Oxidative Stress by Valentina Laghezza Masci, Irene Mezzani, Enrica Alicandri, William Tomassi, Anna Rita Paolacci, Stefano Covino, Vittorio Vinciguerra, Elisabetta Catalani, Davide Cervia, Mario Ciaffi, Stefania Garzoli, Elisa Ovidi

“…Additionally, extracts were obtained from the same tissues of four landraces/clones included in the varietal platform of the PGI “Carciofo Romanesco del Lazio”, which served as reference genotypes: Campagnano, Castellammare, C3, and Grato 1. …”
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A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associat... by Afshana Quadiri, Swayam Prakash, Latifa Zayou, Nisha Rajeswari Dhanushkodi, Amruth Chilukuri, Gemma Ryan, Kelly Wang, Hawa Vahed, Aziz A. Chentoufi, Lbachir BenMohamed

“…Studies on using the mRNA/LNP platform for vaccines have largely focused on the nucleic acid cargo with less attention paid to the LNP vehicle. …”
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Baseline [18F]FDG PET/CT radiomics for predicting interim efficacy in follicular lymphoma treated with first-line R-CHOP by Zeying Wen, Xiaohe Gao, Qingxia Wu, Jianwei Yang, Jian Sun, Keliu Wu, Hongfei Zhao, Ruihua Wang, Yanmei Li

“…Lesion segmentation was performed using LIFEx software, and radiomics features were extracted through the uAI Research Portal (uRP) platform, including first-order features, shape features, and texture features. …”
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Prostate cancer cells elevate glycolysis and G6PD in response to caffeic acid phenethyl ester-induced growth inhibition by Tzu-Ping Lin, Pei-Chun Chen, Ching-Yu Lin, Bi-Juan Wang, Ying-Yu Kuo, Chien-Chih Yeh, Jen-Chih Tseng, Chieh Huo, Cheng-Li Kao, Li-Jane Shih, Jen-Kun Chen, Chia-Yang Li, Tzyh-Chyuan Hour, Chih-Pin Chuu

“…Methods Seahorse Bioenergetics platform was applied to analyzed the extra cellular acidification rate (ECAR) and oxygen consumption rate (OCR) of PCa cells under CAPE treatment. …”
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Impact of viral load on sample pooling for reverse-transcription polymerase chain reaction detection-based diagnosis of coronavirus disease 2019 in Nigeria by Timan T. Eliya, Elvis E. Isere, Bassey Emmana, Chukwuebuka Ugwu, Jonathan Kushim, Precious Ishaku, Aisha E. Ibrahim, John S. Bimba

“…Positive samples were pooled with negative ones at increasing dilution ratios (1:4–1:64), to assess detection sensitivity on the GeneXpert platform. Results: A positive sample with a Ct value ≤ 25 could be pooled with up to 64 negative samples while maintaining a detectable positive result. …”
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Galileo multi-day precise orbit determination using L-band and SLR data by Tianhe Xu, Honglei Yang, Song Li, Zhenlong Fang, Wenfeng Nie, Min Li, Baoguo Yu

“…To explore the rationality and reliability of the L-band and satellite laser ranging (SLR) data processing strategies, we design the Galileo L-band, the SLR-only, and the combined L-band/SLR dynamic precise orbit determination (POD) strategies by using the normal equations (NEQs) stacking, and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023, based on the BeiDou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4. …”
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Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…Methods A Delphi Method process was utilized involving three rounds of questionnaires in which the first two were completed individually online and the third was discussed on a virtual platform with all the panelists. 17 fellowship trained rhinologists across Canada evaluated the 28 original statements on a scale of 1–10 and provided comments. …”
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Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

“…The HB-CCT consisted of the Neurotablet® platform that was used to target cognitive domains such as Attention, Memory, Perception, Executive Functioning and Language. …”
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Robotic versus laparoscopic surgery for severe deep endometriosis: protocol for a randomised controlled trial (ROBEndo trial) by Tero Rautio, Pasi Ohtonen, Outi Uimari, Anna Maria Terho, Johanna Mäkelä-Kaikkonen, Terhi Puhto, Sari Koivurova

“…Advanced endometriosis surgery offers an excellent platform to study the feasibility and long-term outcomes of robotic surgery compared with conventional laparoscopy.Methods and analysis ROBEndo is a prospective, randomised, controlled clinical trial in a single-centre setting. …”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…Interpretation: Lipidots® are effective platform for the development of vaccines against cancer based on mRNA delivery. …”
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Impact of surgical site infection (SSI) following gynaecological cancer surgery in the UK: a trainee-led multicentre audit and service evaluation by Rachel L O’Donnell, Georgios Angelopoulos, James P Beirne, Ioannis Biliatis, Helen Bolton, Melissa Bradbury, Elaine Craig, Ketan Gajjar, Michelle L Mackintosh, Wendy MacNab, Thumuluru Kavitha Madhuri, Mark McComiskey, Eva Myriokefalitaki, Claire L Newton, Nithya Ratnavelu, Sian E Taylor, Amudha Thangavelu, Sarah A Rhodes, Emma J Crosbie, Richard J Edmondson, Yee-Loi Louise Wan

“…There is a clear need for new trials in SSI prevention in this patient group; our trainee-led initiative provides a platform for their successful completion.…”
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The use and subjective experience of sleep apps and their relationship with personality characteristics among young adults by Ståle Pallesen, Ståle Pallesen, Øystein Vedaa, Øystein Vedaa, Erlend Sunde, Erlend Sunde, Anette Harris, Siri Waage, Siri Waage, Ingvild West Saxvig, Jiewen Zhang, Bjørn Bjorvatn, Bjørn Bjorvatn

“…Still, understanding of characteristics of users and the impact of sleep app usage remains limited.MethodsA sample of 940 young adults (18–30 years) living in the UK were recruited from Prolific (online research platform offering researchers access to survey panels) and invited to participate in a survey on the use and experience with sleep apps. …”
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Prediction of coal dust particle size after spraying dust reduction in roadway based on orthogonal experiment and regression analysis by Bingyou JIANG, Yuqian ZHANG, Changfei YU, Ben JI, Haoyu WANG, Zhuang LIU

“…Based on the comprehensive experimental platform for spray dust removal, orthogonal experiments and regression analysis methods were applied to study the change rule of coal dust characteristic particle size D90 after spray dust reduction under the effect of three factors, namely, spray frame distance from dust source, tunnel wind speed and nozzle water supply pressure, and correlation analysis was carried out on 25 groups of experimental results. …”
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