Society for Immunotherapy of Cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing by Ignacio I Wistuba, Michael T Tetzlaff, Carlo B Bifulco, Benjamin Green, Sacha Gnjatic, Scott J Rodig, Joel C Sunshine, Janis M Taube, Keith E Steele, Marlon C Rebelatto, David L Rimm, Ana Lako, Edwin R Parra, Guray Akturk, Michael Angelo, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Kurt A Schalper, Cláudia S Ferreira, Konstanty Korski, Emanuel Schenck, Michael J Surace, Jennifer H Yearley, Jeffrey S Roskes, Margaret Eminizer, Logan L Engle, Daniel Jiménez-Sánchez, Jamie Rodriguez-Canales, Alexander S Szalay

“…The best practice guidelines for staining and validation of mIHC/IF assays across platforms were previously published by this task force. …”
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Effects of NK cell-related lncRNA on the immune microenvironment and molecular subtyping for pancreatic ductal adenocarcinoma by Jinze Li, Chuqi Xia, Yuxuan Li, Hanhan Liu, Cheng Gong, Daoming Liang

“…Immunotherapy, especially therapy based on natural killer (NK) cells, presents a promising avenue for the treatment of PDAC.AimsThis research endeavor seeks to formulate a predictive tool specifically designed for PDAC based on NK cell-related long non-coding RNA (lncRNA), revealing new molecular subtypes of PDAC to promote personalized and precision treatment.MethodsUtilizing the Tumor Immune Single-cell Hub 2 platform, we discovered genes associated with NK cells in PDAC. …”
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Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…Taken together, our results provide an opportunity for developing armored immune cells as an “off-the-shelf” platform for targeted delivery of lactaptin to cancer cells.…”
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Constructing a metadata knowledge graph as an atlas for demystifying AI pipeline optimization by Revathy Venkataramanan, Revathy Venkataramanan, Aalap Tripathy, Tarun Kumar, Sergey Serebryakov, Annmary Justine, Arpit Shah, Suparna Bhattacharya, Martin Foltin, Paolo Faraboschi, Kaushik Roy, Amit Sheth

“…To address this issue, we propose to source AI pipeline metadata from open-source platforms such as Papers-with-Code, OpenML, and Hugging Face. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Following rigorous refinement using the STRING platform and Cytoscape software, we pinpointed ten core targets, encompassing KDM1A, EP300, HDAC2, EHMT2, DNMT1, and several others. …”
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What strategies are used to select patients for direct admission under acute medicine services? A protocol paper for a systematic review of the literature by Elizabeth Sapey, Catherine Atkin, Samuel Evans, Austin Hunt, Georgina Ball, Charlotte Cassidy, Alexander Costley-White, Louise Toy, Rebecca Wilding

“…Covidence software will be the platform for the extraction of data and paper screening with the selection process reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. …”
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Spatial identification of regions exposed to multi-hazards at the pan-European level by T.-E. Antofie, T.-E. Antofie, S. Luoni, A. Tilloy, A. Sibilia, S. Salari, G. Eklund, D. Rodomonti, C. Bountzouklis, C. Corbane

“…<p>The European Commission Disaster Risk Management Knowledge Centre (DRMKC) has developed and hosts a web platform, the Risk Data Hub (RDH), designed to facilitate access to and sharing of curated, EU-wide risk data, tools, and methodologies, ultimately supporting disaster risk management (DRM) initiatives. …”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Methods Using the PRISMA and MOOSE guidelines, Medline, Embase, PsycINFO, and CINAHL+, as well as Clinical Trials gov.uk, OpenGrey, WHO International Clinical Trials Registry Platform, Current Controlled Trials, United States National Institute of Health Trials Registry, and the Irish Health Repository, will be searched from inception. …”
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#emergencymedicine: A TikTok Content Analysis of Emergency Medicine-related Content by Madison Stolly, Erika Wilt, Nathan Gembreska, Mohamad Nawras, Emily Moore, Kelly Walker, Rhonda Hercher, Mohamad Moussa

“…Background: TikTok has rapidly become one of the most extensively downloaded and used social media platforms worldwide. Our focus on emergency medicine (EM)-related content on TikTok is to identify what specific video characteristics result in higher degrees of audience engagement, defined in this study as a total of video likes, comments, and shares. …”
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mHealth-based intervention by community workers to support family caregivers of persons with dementia living at home: study protocol for a cluster randomised controlled trial by Pankaj Bhardwaj, Hanne Konradsen, Manoj Kumar Gupta, Abhik Sinha, Nitin Kumar Joshi, Suresh K Sharma, Naresh Nebhinani, Marie Tyrrell, Åsa G Craftman, Zarina Nahar Kabir

“…Additionally, usability and cost analyses will be conducted to evaluate the practicality and economic feasibility of the intervention.The expected outcomes of this study include the creation of a scalable mHealth platform that facilitates remote support, bridges geographical gaps and enhances the well-being of caregivers in India’s evolving healthcare landscape.Ethics and dissemination Ethical approval has been obtained from the Institutional Ethical Committee of AIIMS Jodhpur (AIIMS/IEC/2022/4245).Trial registration number Clinical Trials Registry: CTRI/2022/12/048320.…”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…The results will be disseminated through peer-reviewed journals, conferences, webinars in multiple languages, regional forums, stakeholder meetings with policymakers and practitioners, public communication through media engagement and open access platforms, including data sharing and early release of findings.Trial registration details Trial registration: NCT06562244; Project page: https://www.flourish-study.org/about.html…”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to improve patient care and management; however, clinical trial evidence to support their use is lacking. …”
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Headache after pediatric traumatic brain injury: a comparison between a post-acute sample of children and adolescents and general population by Marina Zeldovich, Leonie Krol, Katrin Cunitz, Christian Auer, Daniel Pinggera, Victoria Schön, Philipp Geiger, Joachim Suss, Inga K. Koerte, Emilie Isager Howe, Nada Andelic, Anna Buchheim, Matthias Gondan, Nicole von Steinbüchel

“…Trial registration The study is retrospectively registered in German Clinical Trials Register and in International Clinical Trials Registry Platform (ID DRKS00032854).…”
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Ecosystem services value for water provisioning in the Shule River Basin of northwestern China: Spatial and temporal evolution and drivers from 2000 to 2022 by Peng Shi, Dongmei Zhou, Jing Jiang, Jing Ma, Xiaoyan Zhu, Jun Zhang, Zihe Li, Qinghan Dong

“…Analyses were performed using a Geographic Information System (GIS) platform and a geodetector model. The findings were as follows: (1) The value of ecosystem water-provisioning services (measured in monetary terms) in the Shule River Basin showed a fluctuating but increasing trend from 2000 to 2022. (2) The significant fluctuations in the monetary value of ecosystem services from 2000 to 2006 could be primarily attributed to factors such as low precipitation, high temperatures, population growth, and subsequent urban expansion. …”
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TEACHERS’ PROFILE, MOTIVATION, APTITUDE, AND SATISFACTION IN A VIRTUAL UPSKILLING ENVIRONMENT by Dave E. Marcial, Jan Cynth Palama, Fredlie Bucog, Steven Binarao

“…These findings highlight the urgent need to equip teachers with the essential skills and knowledge required for effective online teaching, especially as online learning remains a pivotal platform for continuous professional development. Addressing the deficit in online learning skills while sustaining high motivation and satisfaction among teachers should be a top priority in future education initiatives. …”
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“A one-stop shop”: Real-world use and app-users' experiences of a psychoeducational smartphone app for adults with ADHD by Christina Seery, Rachel Hannah Cochrane, Martha Mulcahy, Ken Kilbride, Margo Wrigley, Jessica Bramham

“…Methods: App analytical data was audited from the Google Analytics platform. Fourteen app-users, nine of whom identified as women and five as men, with an age range of 26–65 (M = 40.29, SD = 11.14), participated in semi-structured interviews. …”
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Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential by Jasbir Kour, Bashir Ahmad Lone, Amit Kumar, Bashir A. Ganai, Govind Yadav, Prasoon Gupta, Md.Niamat Ali, Seema Akbar

“…Its administration decreased the mutagenic load on the cells both in vitro and in vivo experiments Thus the present study provides a platform for the exploration of new plants with potential antimutagenic properties.…”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…The databases/trial registries that will be searched to identify relevant randomised controlled trials (RCTs) and economic evaluations include Medline, EMBASE, CINAHL, PsycINFO, CENTRAL, the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, Cochrane Library, Scopus and the International HTA Database. …”
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Downsystem grain-size trends and mass balance of an ancient wave-influenced sediment routing system: Middle Jurassic Brent Delta, northern North Sea, offshore UK and Norway by Ikenna C. Okwara, Gary J. Hampson, Alexander C. Whittaker, Gareth G. Roberts

“…Sediment was sourced from the west (Shetland Platform), east (Norwegian Landmass) and south (Mid-North Sea High). …”
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Patient Surgical Outcomes When Surgery Residents Are the Primary Surgeon by Intensity of Surgical Attending Supervision in Veterans Affairs Medical Centers by T. Michael Kashner, PhD, JD, MPH, Paul B. Greenberg, MD, MPH, Andrea D. Birnbaum, MD, PhD, John M. Byrne, DO, Karen M. Sanders, MD, Mark A. Wilson, MD, PhD, Marjorie A. Bowman, MD, MPA

“…Using health records from the Department of Veterans Affairs (VA), the largest healthcare training platform in the United States, we estimated independent associations between the intensity of attending supervision of surgical residents and 30-day postoperation patient outcomes. …”
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