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6481
Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric...
Published 2025-02-01“…The DNA was extracted directly from the oronasal swabs, amplified using Mycobacterium genus-specific PCRs, then amplicons were pooled and sequenced using Oxford Nanopore Technologies (ONT) long-read platform. Mycobacterium tuberculosis complex DNA, along with various NTM species, were identified in 8/19 samples. …”
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6482
Performance of a twin-intake diesel engine with a bionic functional surface during an intake process
Published 2025-01-01“…Taking a visualized optical engine as the test platform, the turbulent motion in the cylinder of a diesel engine with different twin-intake combined bionic functional surfaces is studied with the help of particle image velocity (PIV). …”
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6483
Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers
Published 2025-02-01“…Differentially expressed genes (DEGs) identified through scRNA-seq were validated on classical monocytes, and CD4+ and CD8+ T cell subsets derived from an independent cohort of patients using the NanoString nCounter® platform. Protein expression was measured in CD4+ and CD8+ T cells by immunoblotting.ResultsA total of 18 immune cell population clusters were identified. …”
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6484
A retrospective study to understand the differences in maternal mortality among women admitted in critical and stable conditions in Malawi
Published 2025-01-01“…Data were sourced from the national maternal and newborn health surveillance platform. We performed descriptive analyses, stratified by condition on admission, to identify differences in case characteristics between the two groups, and an exploratory survival analysis, to understand the differences in time to death since admission. …”
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6485
Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma
Published 2025-01-01“…<b>Conclusions:</b> These findings demonstrate that nanosilica-crosslinked antioxidant nanoparticles (siRNP) enhance the stability, delivery efficiency, and safety of lipophilic drugs like sorafenib for oral administration. This platform holds promise for improving therapeutic outcomes in lung cancer while minimizing adverse effects.…”
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6486
Current research status and trends of potassium-competitive acid blockers in the treatment of acid-related diseases: a bibliometric analysis
Published 2025-01-01“…We evaluated the publication volume and citation status over the years using the WOS platform, and visualized the authors, countries, institutions, keywords, and citations of the publications using CiteSpace and VOSviewer.ResultsThis study included a total of 455 articles. …”
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6487
EARice10: a 10 m resolution annual rice distribution map of East Asia for 2023
Published 2025-02-01“…Therefore, to acquire the latest rice distribution of the EA, this study proposed a novel rice distribution mapping method based on the Google Earth Engine (GEE) platform, producing a 10 m resolution annual rice distribution map (EARice10) of EA for 2023. …”
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6488
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Published 2025-01-01“…We assessed a semi-high throughput zebrafish screening platform for rapid in vivo functional testing of candidate FBD genes. …”
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6489
A patient-led survey on information and communication needs of patients with metastatic breast cancer in Ireland and Northern Ireland (CTRIAL-IE 23–05)
Published 2025-02-01“…The online survey was publicised nationally on all media platforms. Results: 246 patients completed the survey between July and October 2023. …”
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6490
Polymorphisms in immunosuppression-related genes are associated with AML
Published 2025-02-01“…SNP genotyping was performed on the MassARRAY platform. We then analyzed the relationship between these SNPs and AML susceptibility, treatment response, and prognosis.ResultsOur findings indicated that rs4883263 in the CD163 gene is a protective factor for AML susceptibility and chromosomal karyotype abnormalities. …”
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6491
RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2
Published 2025-02-01“…Conclusions This vaccine platform offers an alternative strategy for developing recombinant subunit vaccines against SARS-CoV-2, potentially enhancing immune responses and improving vaccine efficacy. …”
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6492
Fluorescence Lifetime Imaging of NAD(P)H in Patients’ Lymphocytes: Evaluation of Efficacy of Immunotherapy
Published 2025-01-01“…Conclusions: The proposed platform that includes tumor explants co-cultured with lymphocytes and the NAD(P)H FLIM assay represents a promising solution for the patient-specific immunotherapeutic drug screening.…”
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6493
An ecosystem approach to the evaluation and impact analysis of heterogeneous preventive and/or early interventions projects for veterans and first responders in seven countries
Published 2025-04-01“…Analysis tools include Global Impact Analytics Framework, multi-layered statistical analysis, performance evaluation using an efficient decision support approach, Project and Grant program social return on investment, visual linking and data connection platform and assessment of gendered lens approaches. …”
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6494
Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis
Published 2025-01-01“…Our study highlights the reliability of our FC platform in assessing FVIII abundance on leukocytes’ membranes across coagulation states. …”
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6495
Promoting Computational Access to Digital Collections in the Nordic and Baltic Countries: An Icelandic Use Case
Published 2025-01-01“…Low barrier-to-entry tools, such as the web-based interactive computing platform Jupyter Notebooks have been gradually gaining popularity among users who want to explore digital collections and GLAM institutions that want to provide access to them. …”
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6496
AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma
Published 2025-02-01“…Our NPs act as a facile and effective drug delivery platform for enhanced immunotherapy combined with enhanced PDT in treating MM.…”
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6497
A comprehensive overview of acupuncture therapy over the past 20 years: Machine learning-based bibliometric analysis
Published 2025-03-01“…Methods: The MeSH term ''Acupuncture Therapy'' was used for searching publications from 1st January, 2004–31 st December, 2023 on the PubMed database, while the R platform was adopted to obtain associated data. A topic network was constructed by latent Dirichlet allocation (LDA) and the Louvain algorithm. …”
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6498
Design of a double-blade swirl wet dust collector for comprehensive mining faces
Published 2024-12-01“…Tests on a dust collection experimental platform and in a simulated tunnel indicated that the average dust collection efficiency of the dust collector was 94.80%. …”
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6499
Finite-Time Output Robust Control for Restricted Joint Flight Emulator Robotic Arm With Adaptive Tangent Barrier Gains
Published 2025-01-01“…The robust controller is tested on a reliable platform, a digital replica of the robotic manipulator. …”
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6500
Simultaneous detection of human neutrophil elastase and cathepsin G on a single substrate using a fluorometric quantum dots probe and chemometric models
Published 2025-03-01“…In this study, we propose a novel method combining distinctly sized CdTe quantum dots (QDs) as a fluorescent probe to implement a platform for simultaneous discrimination and quantification of HNE and CatG, applying chemometric analysis.The fluorometric response was acquired using two different methods: kinetic and excitation/emission matrices (EEM). …”
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