Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…Theoretical simulations and experimental studies were combined to optimize their structure and functionality. In vitro platelet aggregation, antibacterial assays, cytotoxicity tests, and hemolysis evaluations were performed. …”
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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…We simultaneously detected blood lipid levels, observed ventricular function using ultrasound examination, measured platelet aggregation, and checked changes in inflammatory factors, oxidative stress factors, and vascular endothelial injury-related indexes applying ELISA assays. …”
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Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC) by M. Jäpel, H. Lötzerich, K. Rogalla

“…In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. …”
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Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports by Xin Liao, Yuxia Guo, Yali Shen, Jianwen Xiao

“…Cases of bleeding disorders ultimately result in thrombocytopenia, but platelet aggregation dysfunction induced by dasatinib has also been demonstrated in Ph + B-ALL and CML patients. …”
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Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells by Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi

“…These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
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Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy by Irina Gringauz, Narin Nard Carmel-Neiderman, Tobin Mangel, Orith Portnoy, Gad Segal, Idan Goren

“…Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. …”
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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…However, after adjustment for baseline differences, platelet aggregation and thromboelastography parameters showed no significant differences between patients with CKD and healthy controls. …”
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Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice by Jui-Chi Tsai, Yi-Wen Lin, Chun-Yao Huang, Feng-Yen Lin, Chien-Sung Tsai

“…However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored. …”
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COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient by Mariana Codevila Buere Pereira, Bruna Ruschel, Bruna Schneider, Vitor Salomão Gonçalves Melo de Melgar, Tatiana Helena Rech

“…The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. …”
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The Interaction of Src Kinase with β3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer by Stephan Huveneers, Erik H. J. Danen

“…The same integrin β3-c-Src interaction not only drives platelet aggregation, but it also promotes the oncogenic potential of c-Src and drives tumor growth by αvβ3-expressing tumor cells, which may explain why increased activity of c-Src and elevated levels of integrin αvβ3 are often found in the same tumor types. …”
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Magnesium and Vascular Changes in Hypertension by Ana Rosa Cunha, Bianca Umbelino, Margarida L. Correia, Mario Fritsch Neves

“…In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. …”
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Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions: Application in Thrombogenicity Testing of Differ... by Wim van Oeveren, Ignace F. Tielliu, Jurgen de Hart

“…Platelet numbers were reduced in the roller pump and Chandler loop (P<0.05), but remained high in the Hemobile. Platelet aggregation was reduced in all models. The Hemobile was applied for testing vascular graft materials, and allowed different circuits circulated simultaneously at 37°C. ePTFE, Dyneema Purity UHMWPE fiber and PET fiber based tubes, all showed hemolysis below 0.2% and reduced platelet count and function. …”
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Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati by N. Abdel Karim, S. Haider, C. Siegrist, N. Ahmad, A. Zarzour, J. Ying, Z. Yasin, R. Sacher

“…Thrombotic Thrombocytopenic Purpura (TTP) is a rare hematologic emergency, congenital or acquired, characterized by ischemic damage of various organs because of platelet aggregation. It is the common name for adults with microangiopathic hemolytic anemia, thrombocytopenia, with or without neurologic or renal abnormalities, and without another etiology; children without renal failure are also described as TTP. …”
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Glanzmann’s Thrombasthenia Diagnosed following Knee Arthroscopy by John E. Zvijac, Sharhabil S. Ammus, Fernando Aran, Gary M. Kiebzak

“…A hematologist was consulted and comprehensive platelet aggregation testing revealed previously undiagnosed Glanzmann’s thrombasthenia. …”
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Perbandingan Jumlah Trombosit pada Pasien COVID-19 dengan Kadar Glukosa yang Berbeda by Imanta Alifia Octavira, Agrijanti Agrijanti, Lalu Srigede, Siti Zaetun

“…Thrombocytopenia in COVID-19 patients occurs through a variety of mechanisms, such as uncontrolled production of cytokines destroying bone marrow progenitor cells, direct inhibition of hematopoiesis viral infection of the bone marrow, increase in autoantibodies and immune complexes that cause platelet destruction, and lung injury that causes platelet aggregation and consumption of platelets so that platelets in the circulation are reduced. …”
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The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions by Gulbarchyn Alisherovna Asrankulova, Zhyldyz Akmatovna Makhmudova, Mahira Rysbaevna Mirzaeva, Meerim Taalaibekovna Taalaibekova, Zyinat Samidinovna Boronova, Mairambu Bektemirovna Zhorobekova

“…It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. …”
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Subcutaneous Dorsal Penile Vein Thrombosis or Penile Mondor’s Disease: A Case Report and Literature Review by Adama Ouattara, Abdoul Karim Paré, Aristide F. Kaboré, Clotaire Yaméogo, Gnimdou Botcho, Désiré Ky, Abdoul Aziz Ouédraogo, Amidou Bako, Rigobert Kiba, Zakari Nikiéma, Timothée Kambou

“…The patient receives nonsteroidal anti-inflammatory drugs and coagulation and platelet aggregation inhibitors drugs. Healing and total recovery occur after eight weeks without any complications.…”
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Atypical Thrombotic Thrombocytopenic Purpura Presenting as Stroke by Pradeepthi Badugu, Modupe Idowu

“…In the early stages of the disease, platelet aggregation and thrombus formation may not be widespread, and thrombocytopenia and microangiopathic hemolytic anemia may not be clinically evident. …”
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Comparison of effectiveness of aspirin, clopidogrel and cilostazol monotherapy treatment in ischaemic stroke by Endarwati Tuti, Kurniasih Khamdiyah Indah, Fauziah Fauziah, Sunarti Sunarti, Agus Salim Muh.

“…Because antiplatelet medication does not improve platelet aggregation, ischemic stroke patients have significant death and disability rates. …”
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Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review by Amber N. Edinoff, Keerthiga Raveendran, Marc A. Colon, Bennett H. Thomas, Katie A. Trettin, Grace W. Hunt, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye

“…The inhibition of serotonin reuptake can affect platelet aggregation since platelets also express the serotonin transporter. …”
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