Dynamic Changes in Parameters of Complete Blood Count Predict Disease Severity and Prognosis in Patients with COVID-19; A Prospective Study by Toktam Alirezaei, Mahdi Baratnia, Rama Bozorgmehr, Yasamansadat Keshmiri, Faezeh Ebrahimpour, Maryam Arefnia, Mohammadali Ghodsirad

“…Considering dynamic changes in blood elements, repeated measured ANOVA showed patients who survived had a decrease in WBC and Neutrophil count as well as Neutrophil to lymphocyte ratio (NLR) compared to expired patients; in contrast, platelet and lymphocyte count increased in survivors while dropped in deceased ones. …”
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The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Secondary outcomes were glycosylated hemoglobin A1c (HbA1c), body mass index (BMI), lipid profiles, hematological indexes including hematocrit and platelet count, and systematic inflammatory level expressed as a C-reactive protein (CRP) level. …”
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Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy by Qianqian Li, Ran Wang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Kexin Zheng, Xiaolong Qi, Yingying Li, Xingshun Qi

“…Liver fibrosis blood tests, platelet count/spleen diameter ratio (PSR), and contrast-enhanced CT are diagnostic alternatives for gastroesophageal varices, but they have heterogeneous diagnostic performance among different study populations. …”
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Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Previously, we reported a novel BCL2 inhibitor, Disarib, which inhibited BCL2 by predominantly binding to its BH1 domain and exhibited platelet-sparing ability like ABT199, the only FDA-approved BCL2 inhibitor. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Frequently observed adverse events included decreases in neutrophil counts (74.4%), white blood cell counts (64.1%) and platelet counts (64.1%). Conclusions This study highlights the potential of linperlisib plus GEMOX as a treatment for R/R DLBCL, demonstrating a tolerable safety profile and encouraging efficacy results. …”
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Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study by Vlad M. Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur

“…The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae. …”
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Persistent Mortality Risk From Device-related Healthcare-associated Infection in Kidney Transplant Recipients Despite Multifaceted Interventions Action Calls for a Zero-tolerance P... by Maria Bethânia Peruzzo, MD, Luana Oliveira Calegari, MSc, Renato Demarchi Foresto, MD, PhD, Helio Tedesco-Silva, MD, PhD, José Medina Pestana, MD, PhD, Lúcio Requião-Moura, MD, PhD

“…Additional variables associated with increased risk of death included age (HR, 1.03; P < 0.001), baseline immunosuppression (HR based on mycophenolate versus others 0.74; P = 0.02), time since transplantation (HR, 1.003; P < 0.001), platelet count at ICU admission (HR, 0.998; P < 0.001), and sepsis as the reason for ICU admission (HR, 1.67; P < 0.001). …”
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The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Human blood derivatives, for example, platelet-rich plasma (PRP) releasates, are potential replacements of FCS; however, it is unclear which serum variant has the best effect on the given cell or tissue type. …”
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CYP2C19 Genotype‐Guided Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing a Neurointerventional Procedure by Kayla R. Tunehag, Ashton F. Pearce, Layna P. Fox, George A. Stouffer, Sten Solander, Craig R. Lee

“…However, patients carrying CYP2C19 no‐function alleles have diminished capacity for inhibition of platelet reactivity due to reduced formation of clopidogrel's active metabolite. …”
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Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…SII in TIC group was significantly higher than that in non-TIC group. neutrophil count (NEU), platelet count (PLT), lymphocyte count (LYM), activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB) level, and D-Dimer (D-D) level in TIC group were higher than those in non-TIC group, while LYM, FIB was lower than that in non-TIC group. …”
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Ekspresi PDGF-B dan SCUBE 1 pada Arteri Karotis Mencit yang Diligasi dan Tidak Diligasi by Ranti Verdiana, Hirowati Ali, Husnil Kadri

“…Intimal thickening occurs through an inflammatory process that involves cytokines such as PDGF-B and SCUBE 1 that are found in platelet and endothelial cells.The objective of this study was to determine the expression of PDGF-B and SCUBE 1 in ligated and non ligated carotid artery of mice.The design study was experimental. …”
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Synthesis and Evaluation of PCL/Chitosan/CQD‐Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression by Elham Maghareh Abed, Fatemeh Yazdian, Abbas Akhavan Sepahi, Behnam Rasekh

“…The relative expression of genes platelet‐derived growth factor (PDGF), transforming growth factor beta (TGF‐β), and matrix metalloproteinase‐1 (MMP1) was assessed through RT‐PCR. …”
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Comprehensive Evaluation of Inflammatory Biomarkers in Cervical Cancer Treated with Chemoradiotherapy by Timur Koca, Nurcihan Gocen Vardar, Rahmi Atıl Aksoy, Aylin Fidan Korcum

“…<b>Results:</b> The univariate analysis identified the following as predictors of progression-free survival (PFS): neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR), systemic immune-inflammation index (SII), PIV, C-reactive protein (CRP), albumin, and tumor size. …”
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Development and validation of predictive models of early immune effector cell–associated hematotoxicity by Emily C. Liang, Jennifer J. Huang, Andrew J. Portuguese, Valentín Ortiz-Maldonado, Aya Albittar, Natalie Wuliji, Ryan Basom, Yein Jeon, Qian Wu, Aiko Torkelson, Delaney Kirchmeier, Abigail Chutnik, Barbara Pender, Mohamed Sorror, Joshua A. Hill, Noam E. Kopmar, Rahul Banerjee, Andrew J. Cowan, Damian Green, Ajay K. Gopal, Christina Poh, Mazyar Shadman, Alexandre V. Hirayama, Brian G. Till, Erik L. Kimble, Lorenzo Iovino, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Filippo Milano, Cameron J. Turtle, David G. Maloney, Jordan Gauthier

“…We trained (n = 483) and validated (n = 208) 2 eICAHT prediction models (eIPMs): eIPMPre including preinfusion factors only (disease type and pre-LD ANC, platelet count, LDH, and ferritin) and eIPMPost containing both preinfusion (disease type and pre-LD ANC, platelet count, and LDH) and early postinfusion (day +3 ferritin) factors. …”
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Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…ObjectivesPreoperative peripheral hematological indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and prognostic nutritional index (PNI), exhibit promise as prognostic markers for glioma. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…ASCs were isolated from healthy voluntary donors, expanded using a human platelet lysate in bioreactors, and cryopreserved as per clinical use. …”
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A Clinical Monitoring Program of COVID-19 Outpatients: A Prospective Cohort Study by Hossein Kasiri, Cyrus Mahjub, Mohammadreza Mazaeri, Fahimeh Naderi-Behdani, Aliyeh Bazi, Monireh Ghazaeian, Sahar Fallah

“…C-reactive protein, white blood cell, lymphocyte, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and hemoglobin levels were recovered significantly during the first two weeks (P<0.001). …”
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Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations by Ayobami O. Sobanke, Afusat Aiyeola, Frances I. Okwuonu, Wuraola S. Nnaemeka, Jeremiah C. Ndubuisi, Franklin I. Udeoji, Jane N. Adiele

“…However, there was a significant rise in the levels of inflammatory markers, platelet counts, LDL-c triglyceride (TG), total cholesterol (TC), and white blood cell (WBC). …”
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IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis by Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee

“…The IL-6/PD-1 group had lower neutrophil percentage and platelet count compared with the CLP group; no significant difference was observed in other cytokine levels. …”
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Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver... by Mohammad Hossein Anbardar, Neda Soleimani, Kourosh Kazemi, Zahra Jafarpour, Mahsa Hasani, Sahand Mohammadzadeh, Parnia Torfehnezhad, Sedighe Jafarian, Mahsa Farhadi, Mina Salari Sardari

“…In addition, some instances revealed increased LDH, increased WBC, decreased hemoglobin, and decreased platelet count. Most patients had increased prothrombin time; hematuria and positive stool occult blood were observed in few patients. …”
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