Living, Caring, Learning – Setting boundaries for the wellbeing of everyone in bleeding disorders care by Harrison Cathy

“…Cathy, a haemophilia nurse specialist in the UK, reflects on a challenging patient with a rare inherited platelet disorder. The patient did not attend regular clinic appointments, and when presenting at clinic due to severe bleeding or feeling unwell was often aggressive and abusive towards staff. …”
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Surface Modification of Biomaterials: A Quest for Blood Compatibility by Achala de Mel, Brian G. Cousins, Alexander M. Seifalian

“…These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. …”
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A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence by Shoja Rahimian, Timothy Johnson, Ronald Herb

“…Improved management of such cases depends on the recognition of the combined occurrence of ET and glomerular diseases and uncovering the shared pathogenesis between platelets and glomeruli.…”
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Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient by Jorge Avila, Huseyin Berk Degirmenci, Pamela Contreras Chavez, Elisabeth M. Battinelli, Jorge Fleisher

“…He responded to the first-line ITP treatment with corticosteroids and intravenous immunoglobulin (IVIG) as evidenced by the fast recovery of platelet count and lack of recurrence of thrombocytopenia.…”
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An Atypical Presentation of Brucellosis in a Patient with Isolated Thrombocytopenia Complicated with Upper Gastrointestinal Tract Bleeding by Suleyman Baldane, Serdar Sivgin, Tahsin Sezgin Alkan, Fatih Kurnaz, Cigdem Pala, Muzaffer Keklik, Ahmet Karaman, Leylagul Kaynar

“…In laboratory tests, the platelet count was found to be /L. Intravenous or oral corticosteroid treatment was thought to be given for ITP but disclaimed due to upper GIS bleeding. …”
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Effects of esculentoside A on turnour necrosis factor production by mice peritoneal macrophages by Fang Jun, Zheng Qin Yue, Wang Hong Bin, Ju Dian Wen, Yi Yang Hua

“…Previous studies have showed that EsA reduced the releasing of platelet activating factor (PAF) from rat macrophages. …”
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Splenic Complications of Babesia microti Infection in Humans: A Systematic Review by Igor Dumic, Cristian Madrid, Libardo Rueda Prada, Charles W. Nordstrom, Pahnwat Tonya Taweesedt, Poornima Ramanan

“…Furthermore, admission hemoglobin of 10 mg/dl or less, platelet count of 50 × 10⁹/L or less, presence of hemodynamic instability, and splenic rupture were associated independently with an increased risk of requiring splenectomy. …”
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Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy by Irina Gringauz, Narin Nard Carmel-Neiderman, Tobin Mangel, Orith Portnoy, Gad Segal, Idan Goren

“…Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. …”
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Immune complex induced arthritis in rats: role of lipid mediators on cell infiltration by F. A. C. Rocha, L. E. C. Andrade, S. Jancar

“…Pretreatment with WEB 2170, a platelet activating factor (PAF) antagonist, also significantly inhibited cell influx. …”
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Multiple Culprit Coronary Artery Thrombosis in a Patient with Coronary Ectasia by Bruno da Silva Matte, Gustavo Neves de Araujo, Felipe Homem Valle, Ana Maria Rocha Krepsky

“…We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may have caused plaque disruption in another already vulnerable vessel.…”
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Simultaneous Manifestation of Chronic Myelomonocytic Leukemia and Multiple Myeloma during Treatment by Prednisolone and Eltrombopag for Immune-Mediated Thrombocytopenic Purpura by Masao Hagihara, Morihiro Inoue, Kenichiro Kodama, Tomoyuki Uchida, Jian Hua

“…He was diagnosed with idiopathic thrombocytopenia, and prednisolone together with eltrombopag was started, leading to significant improvement of platelet counts. Four years later, there was a prominent increase of peripheral blood monocytes, which was accompanied by recurrence of thrombocytopenia. …”
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Performance of Novel Randomly Oriented High Graphene Carbon in Lithium Ion Capacitors by Rahul S. Kadam, Kishor P. Gadkaree

“…This data clearly shows advantage of the randomly oriented graphene platelet structure of ROHG in lithium ion capacitor performance.…”
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A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease by Keynaz Keykavousi, Fahimeh Nourbakhsh, Nooshin Abdollahpour, Farzaneh Fazeli, Alireza Sedaghat, Vahid Soheili, Amirhossein Sahebkar

“…The purpose of this review is to investigate the role of hematological (white blood cell (WBC), lymphocyte, and neutrophil count, neutrophil-to-lymphocyte ratio (NLR), platelet, and red blood cell (RBC) count), inflammatory (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH)), and biochemical (Albumin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, D-dimer, total Cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) biomarkers in the pathogenesis of COVID-19 disease and how their levels vary according to disease severity.…”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…Subsequent experiments including scanning electron microscopy, flow cytometry, western blotting, and network pharmacology analysis have revealed that AC-AgNPs can cause platelet activation and aggregation, stimulated kallikrein-kinin system, shorten activated partial thromboplastin and prothrombin time, and increase fibrinogen content. …”
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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments by Juan Marta-Enguita, Florencio J.D. Machado, Josune Orbe, Roberto Muñoz

“…Thus, variable proportions of fibrin-/platelet-rich and erythrocyte-rich areas are closely interrelated within the thrombus, frequently associated with a protective outer shell with high concentrations of fibrin, NETs, and von Willebrand Factor. …”
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Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy by N.O. Pertseva, T.S. Turlyun, N.A. Sanina

“…The obtained results testify to the dominant role of type 2 diabetes as a factor in platelet disorders of hemostasis. Taking into account the positive dynamics of the above-mentioned markers of ED during the year of treatment, their relationship with the reduction of blood pressure, indicators of the lipid spectrum and abdominal obesity, it should be noted the positive effect of angiotensin II receptor blockers (BRA II) as endothelioprotective drugs. …”
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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 by Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Yoshiko Kadokawa, Takuya Tsutsumi, Shotaro Tsuruta, Yuji Kato, Osami Inoue, Noboru Kinoshita, Kazuo Ohba, Hiroyuki Kato, Kazuyuki Ohata, Junichi Masuda, Keisuke Hamasaki, Hiroshi Yatsuhashi, Kazuhiko Nakao

“…There was no significant difference in the level of HCV RNA, BMI, platelet, TG, or stage of fibrosis between the groups. …”
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Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies by Lisa M. Billesberger, Kyle M. Fisher, Yawar J. Qadri, Richard L. Boortz-Marx

“…Newer injectable therapies are gaining attention as alternatives to medications because of a safer side effect profile and are much less invasive than a joint replacement. Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect. …”
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FREQUENCY OF NEONATAL SEPSIS AMONG NEONATES PRESENTING WITH SEIZURES by Abid Imran, Sijad-Ur- Rehman, Imran Qadir, Kainaat Sheikh, Romana Bibi, Muhammad Idrees

“…From all neonates, 5cc of venous blood was obtained under strict aseptic technique and was sent to hospital laboratory for measuring the TLC, Absolute neutrophil count, CRP and platelet count to confirm the presence or absence of neonatal sepsis.   …”
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Aortic Pseudoaneurysm following Ventricular Septal Defect Closure in a Pediatric Patient: A Case Report and Literature Review by Hassan Zamani, Kourosh Vahidshahi, Mohammad Reza Khalilian, Tahmineh Tahouri, Ehsanollah Rahimi-Movaghar

“…The fever started on the 30th day after the surgery, and the patient exhibited abnormal laboratory results, including a white blood cell (WBC) count of 28.3×109/L, neutrophil percentage of 68%, platelet count of 880×109/L, erythrocyte sedimentation rate (ESR) of 200 mm/hour, and 3+ positive C-reactive protein. …”
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