Severe Late-Onset Drug-Induced Immune Thrombocytopenia Following IFN β-1a Treatment: A Case Report of a 52-Year-Old Woman with Relapse-Remitting Multiple Sclerosis by Christophe Cisarovsky, Marie Théaudin, Pierre-Alexandre Bart, Grégoire Stalder, Lorenzo Alberio

“…Platelets came back to normal after intravenous immunoglobulins and IFNβ1a was definitively discontinued. …”
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Biologic Augmentation of the Ulnar Collateral Ligament in the Elbow of a Professional Baseball Pitcher by James K. Hoffman, Nicole M. Protzman, Amit D. Malhotra

“…A construct comprising a dermal allograft, platelet rich plasma (PRP), and mesenchymal stem cells (MSCs) has been shown to successfully improve healing in the rotator cuff. …”
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Hyperacute Therapies for Childhood Stroke: A Case Report and Review of the Literature by Jose Irazuzta, Kevin J. Sullivan

“…Mechanical thrombectomy, intra-arterial administration of rt-PA, vasodilators, and platelet inhibitors, and systemic anticoagulation and subsequent critical care support. …”
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Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases by Sunita Sharma, Anita Nangia, Sonal Jain Malhotra, Shashi Narayan, Aparna Harbhajanka, Sarika Singh

“…Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. …”
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Pancytopenia in a Patient with Rendu-Osler-Weber Syndrome and Uncommon Vascular Abnormalities by Nicolò Binello, Antonio Gasbarrini, Eleonora Gaetani

“…The patient underwent coil embolization of the splenic artery aneurysm, followed by rapid and sustained increase of white blood cell and platelet count. Splenic artery aneurysms are extremely uncommon in HHT as only anecdotal cases have been reported to date. …”
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Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant by Muhammad Husnain, Trent Wang, Maikel Valdes, James Hoffman, Lazaros Lekakis

“…ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesis on bone marrow evaluation. …”
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Thrombocytopenia in Critically Ill Children: A Review for Practicing Clinicians by Balagangadhar R. Totapally, Abhinav Totapally, Paul A. Martinez

“…Finally, this review analyzes platelet transfusions, the various thresholds, and complications.…”
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Primary Cardiac Lymphoma Presenting with Thrombocytopenia, Right Heart Failure, and Cardiogenic Shock by Samantha Kurniawan, Gita Mathur, Yvonne Bogun, Giselle Kidson-Gerber

“…The patient stabilised with initiation of high dose steroids prior to tissue diagnosis and platelet counts normalised following chemotherapy. …”
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The Mechanisms of Sepsis Induced Coagulation Dysfunction and Its Treatment by Zhu L, Dong H, Li L, Liu X

“…Its mechanisms involve platelet activation, coagulation cascade activation, inflammatory reaction imbalances, immune dysregulation, mitochondrial damage, neuroendocrine network disruptions, and endoplasmic reticulum (ER) stress. …”
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A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit by Kevin Lee, Sophia Toraby, Robert Cotterman, Babatunde Oriowo, John Fish

“…We also completed a literature review of the molecular mechanisms in which testosterone can increase the clot burden through an increases human platelet thromboxane A2 receptor density and an increase in erythropoiesis.…”
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Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ... by Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, Jonas Mattsson, MD, PhD

“…This study aimed to assess the impact of granulocyte colony-stimulating factor (G-CSF) administration posttransplantation on neutrophil and platelet engraftment, incidence of bloodstream infections (BSIs), graft-versus-host disease, engraftment syndrome (ES), and survival metrics including overall survival, nonrelapse mortality, and graft-versus-host disease–free/relapse-free survival. …”
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Presumed Glenoid SLAP Tear in an Adolescent Football Player Belied the Presence of a Coracoid Growth Plate Fracture: A Diagnostic Conundrum by John G. Skedros, J. Hunter Marshall, John T. Cronin

“…Hoping to expedite his healing with platelet or stem cell injections, the parents sought an opinion from another physician who obtained a right shoulder MRI with intra-articular contrast. …”
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Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction by N. Nathan, Y. Denizot, P. Feiss

“…High plasma levels of 6- keto-prostaglandin (PG) F1α (the stable metabolite of PGI2), interleukin (IL)-6 and IL-8 are observed whereas plasma tumour necrosis factor alpha (TNFα), TxB2 (the stable metabolite of TxA2), PGE2, leukotrienes (LT)B4 and LTC4, and whole blood platelet-activating factor levels are not different from values obtained in similarly severe atherosclerotic patients. …”
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Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration by Pradeep V. Mahajan, Swetha Subramanian, Siddhesh C. Parab, Sanskruti Mahajan

“…We injected autologous mesenchymal stem cells obtained from the bone marrow and adipose tissue and platelet-rich plasma into the joint of the patient at the area of injury, as well as intravenously. …”
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ABO Blood Groups and Cardiovascular Diseases by Hanrui Zhang, Ciarán J. Mooney, Muredach P. Reilly

“…Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…These cellular therapies could be further complemented by platelet-derived biomaterials, TCM formulations, or any specific drug. …”
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Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells by Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi

“…These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
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Fat Graft Myringoplasty versus Chemical Cauterization in Small Tympanic Membrane Perforation:A Comparative Study by Vertika Tewari, Mohamed Tabrez Bahauddin Gafoor, Harendra Kumar Gautam, Azme Zehra, Priyali Singh

“…A variety of autografts have been used for closure of tympanic membrane perforation such as perichondrium. temporalis fascia, cartilage fat, platelet rich plasma, and chemical cauterization. …”
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Emergency Splenectomy in a patient with primary immune thrombocytopenia and hemoperitoneum by Liermis Michael Dita Salabert, José Eduardo Consuegra Díaz, Carlos Jaime Geroy

“…Primary immune thrombocytopenia is an acquired autoimmune disease, with a very variable clinical course, which causes an accelerated destruction by antibodies and an impaired platelet production. A case of a 40 year-old female patient of rural origin with a history of mitral stenosis and atrial fibrillation, diagnosed two months prior to her admission to the Dr. …”
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Ibrutinib-Associated Cardiac Tamponade with Concurrent Antiplatelet Therapy by Jennifer L. Miatech, John H. Hughes, Dillon K. McCarty, M. Patrick Stagg

“…The increased bleeding tendency associated with ibrutinib is thought to be related to its effect on several platelet signaling pathways, which can be exacerbated in the setting of concurrent antiplatelet or anticoagulant therapy. …”
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