Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…However, clopidogrel responsiveness shows variability based on CYP2C19 polymorphism. Therefore, we planned a study with an objective of evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of a novel thienopyridine antiplatelet agent AT-10 in healthy Indian subjects compared with standard dosage regimen of clopidogrel based on their CYP2C19 genotyping.Methods Two CYP2C19 genotype–based groups were identified, that is, poor metabolisers and extensive metabolisers, with 20 subjects in each group (n=40) for participating in a randomised, two-period, crossover study. …”
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Smallholder farmers’ knowledge, attitudes and practices towards biological control of papaya mealybug in Kenya by Kate Constantine, Fernadis Makale, Idah Mugambi, Harrison Rware, Duncan Chacha, Alyssa Lowry, Ivan Rwomushana, Frances Williams

“…By building awareness and capacity, and developing a management plan with farmers that will support the release and establishment of the biological control agent, Acerophagus papayae, long-term, sustainable control of PMB in Kenya is possible.…”
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Analysis of Factors Affecting Consumer Decision-Making in Choosing Online Food Delivery in Indonesia by Elysia Elverda, Tasliyah Athaya Nahdah, Sambudi Hamali

“…Research implication: The desire to repurchase through OFDs can be achieved through affordable product prices, having a communication plan that makes customers feel valued when using the website, implementing advertising strategies to make the website easy to use, fast and quality responses, and attractive visual features and designs. …”
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Cardiometabolic risk factors in the Swedish Werlabs cohort based on self-initiated health screening: cohort profile by Peter Ueda, Kerstin Brismar, Anna Norhammar, Daniel Peter Andersson, Hannah Coudé Adam, Omid Hajimirsadeghi, Lovisa Krantz, Nadia Bandstein Forsberg

“…In an analysis restricted to 621 individuals with recorded blood pressure data between the age of 40 and 70 years and without existing cardiovascular disease, diabetes or kidney disease, 35,4% were classified as high or very high cardiovascular risk according to the 2021 ESC guidelines on cardiovascular disease prevention and with lipid levels that made them eligible for lipid-lowering therapy.Future plans The Werlabs cohort comprises a rather healthy and young population that can provide opportunities for future studies on individuals undergoing self-initiated health examinations and has the potential to impact treatment of cardiometabolic risk factors.…”
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Villes durables : leviers de nouveaux modèles économiques et de développement? by Jean-Christophe Lipovac, Antoine Boutonné

“…La concrétisation de la ville durable requiert de réinterroger le modèle de développement économique du territoire et les modèles économiques d’entreprise qui y sont associés afin de mettre en œuvre des solutions nouvelles répondant à d'autres modes de vie urbains, prenant en charge des effets non souhaités (positifs ou négatifs) sur un plan environnemental, écologique et social, et favorisant l'intégration des fonctions de la ville. …”
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Actualización sobre COVID-19 y embarazo by Alberto Antonio Sosa Osorio, Yoan Hernández Cabrera, Yuleydi Alcaide Guardado, Yadira Nualla Pérez

“…Se considera que las embarazadas están en mayor riesgo de complicaciones por COVID-19, morbilidad obstétrica y mortalidad perinatal. El plan terapéutico para gestantes no difiere al establecido para el resto de los grupos poblacionales y está basado en el cumplimiento del aislamiento y las medidas generales.…”
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Metodología con enfoque multicriterio para la gestión de riesgos tecnológicos de Ortopedia en hospitales by Leudis Orlando Vega de la Cruz, Milagros de la Caridad Pérez Pravia, Mayra del Rosario Moreno Pino

“…Con la implementación del Plan de prevención de riesgos se logró incrementar el nivel de detección de riesgos y su actualización; así como una disminución de la relación evaluación-riesgos.…”
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Orthodontic interventions as a management option for children with residual obstructive sleep apnea: a cohort study protocol by Carlos Flores-Mir, Nathalia Carolina Fernandes Fagundes, Arnaldo Perez-Garcia, Daniel Graf, Giseon Heo

“…A sample size of 70 participants (n=35 per cohort) is planned. Effectiveness data will be assessed through nocturnal polysomnography, a craniofacial index, sleep questionnaires and medical records. …”
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Economía circular y ambiente: una evaluación económico-financiera para la instalación de una planta de reciclaje de residuos de aparatos eléctricos y electrónicos en la ciudad de B... by José Ignacio Diez, Lorena Tedesco, Agustín Imaz-Harguindeguy

“…También se incluyó la posibilidad de un financiamiento, lo que hizo que el plan fuera menos rentable aún, y se midió la sensibilidad de los resultados: se halló que el precio debiera ser 1.48 % superior al utilizado en el análisis. …”
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Conductas sexuales en hombres que tienen sexo con hombres con exceso de peso by Carlos Alberto Catalán-Gómez, Raquel Alicia Benavides-Torres, Dora Julia Onofre Rodríguez, Velia Margarita Cárdenas Villareal

“…Aunque al menos la mitad tiene un plan para practicar sexo seguro, menos del 50% utiliza condón regularmente y muchos no son capaces de negociar su uso con sus parejas. …”
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20 ans d’Observatoire photographique des paysages dans le Parc naturel régional des Vosges du Nord by Romy Baghdadi

“…In summary, the question concerns how to privilege initially resorting to a vertical representation of a part of an area, the visible part, its perspective, successive interpretations and structural elements, rather than resorting to maps or plans, which are more often used but remain less palpable and less evocative for the inhabitants of the area.…”
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Evidencia de procesos erosivos en la bahía El Ferrol en Perú, para el periodo 1974-2020 by Rómulo Loayza-Aguilar

“…Se plantean escenarios de modelación numérica para establecer un plan de recuperación. …”
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Postoperative fever following surgery for oral cancer: Incidence, risk factors, and the formulation of a machine learning-based predictive model by Yanling Zhang, Kun Long, Zhaojian Gong, Ruping Dai, Shuiting Zhang

“…Machine learning algorithms can be effectively used to identify potential risk factors of POF, which may enhance individualized treatment plans in oral cancer patient during perioperative period. …”
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A War Tactician: K̲h̲ālid b. al-Walīd by Hüseyin Gökalp

“…His membership to brave Arab tribes or his desert environment also does not give necessary information to explain his professional diplomatic attempts, detailed field plans, and elegant army order on the battlefields. …”
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Mathematical model for energy savings in blood donations at the Cienfuegos Blood Bank by David Lorenzo Calles, Manuel E. Cortés Cortés

“…<br /><strong>Objective:</strong> to develop a statistical-mathematical model to determine the number of blood donors who minimize electricity consumption at the Cienfuegos Blood Bank and comply with the institution's plans.<br /><strong>Methods:</strong> statistical-mathematical tools were used to determine the minimum number of donations to be made at the Cienfuegos Blood Bank to reduce electricity consumption. …”
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Developing an indicator system and assessing China's progress on climate change adaptation in 2010–2022 from dual-dimension by Yang Song, Xiu Yang, Huimin Li, Mingyu Liu

“…The Chinese government has implemented a series of measures to adapt to climate change in alignment with national economic and social development plans, yielding positive outcomes. Based on relevant theories, practices, and domestic and international strategic arrangements, we have developed an assessment indicator system from dual-dimension, encompassing both the adaptive stage and the adaptive sector, to assess China's progress in adapting to climate change over the period from 2010 to 2022. …”
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Preoperative ANemiA among elderly undergoing Major Abdominal surgery (PANAMA) is associated with early postoperative morbidity and worse quality of life outcomes by Hairil Rizal Abdullah, Celestine Jia Ling Loh, Eunice Jie Yi Kok, Brenda Pei Yi Tan, Hanis Abdul Kadir, Phui-Sze Au-Yong

“…Patients were included if they were 65 years or older, could provide written informed consent and were planned for elective major abdominal surgery. Patients were excluded if they were going for organ transplant surgery. …”
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Experimental Approach for the Evaluation of the Performance of a Satellite Module in the CanSat Form Factor for In Situ Monitoring and Remote Sensing Applications by Juan Sebastián Rodríguez, Andrés Yarce Botero, Diego Valle, Julián Gálvez- Serna, Francisco Botero

“…This experiment’s interest measured thermodynamic variables and the concentration of pollutants in the stratosphere to corroborate the operating ranges planned in the above experiments using on-flight conditions and estimate the TLR (technology readiness level) of future prototypes.…”
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An Effective Sol-Gel-Functionalized Polyurethane Foams Solid Platform Packed Minicolumns for Complete Extraction of Chromium (VI) from Water: Kinetic, Sorption Isotherms, Thermodyn... by Effat A. Bahaidarah

“…Thus, the current study reports the use of sol-gel-functionalized polyurethane foams (PUFs) as a novel solid platform for complete extraction of chromium (VI) species from aqueous media. The planned protocol was based upon the complete extraction of the formed binary complex ion associates between the protonated ether and/or urethane groups of PUFs and chlorochromate anion [CrO3Cl]−aq in aqueous HCl (≥1M) medium in addition to H-bonding and the electrostatic π–π interaction that resulted between the CrO3Cl− and the silanol group (Si/ZrO2, Si–O–Zr) and siloxane (Si–O–Si) groups of the sol-gel. …”
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A Semianalytical Production Prediction Model and Dynamics Performance Analysis for Shale Gas Wells by Yingying Xu, Xiangui Liu, Zhiming Hu, Xianggang Duan, Jin Chang

“…The findings of this study can help for better ensuring the prediction accuracy of the estimated ultimate recovery and understanding the main influencing factors of the dynamic performance of gas wells so as to provide a theoretical reference for production optimization and development plan formulation of the shale gas reservoirs.…”
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