Hypoxia-Induced GST1 Exerts Protective Effects on Trophoblasts via Inhibiting Reactive Oxygen Species (ROS) Accumulation by Lingjuan Chen, Gaoli Chen, Lixuan Guo, Yaping Wang, Chengjin Ai

“…GSTP1 expression in first-trimester villi placentas was much higher than that in full-term placentas. …”
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Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages by Fred Owino, Fred Owino, Fred Owino, Caroline Kijogi, Caroline Kijogi, Caroline Kijogi, Omu Anzala, Omu Anzala, Edwin Walong, Obiero Jael, Steven G. Nyanjom, Agola Lelo Eric, Bernard N. Kanoi, Bernard N. Kanoi, Jesse Gitaka, Jesse Gitaka

“…Here, we determined the influence of placental malaria on decidual macrophages, by assessing their distribution based on their unique phenotypes, and examining their expression levels of transcription factors as well as angiogenic factors, in placentas from women living in a malaria-endemic area.MethodsWe compared these macrophage parameters in placentas from malaria infected women to those from the uninfected women. …”
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Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy by Alexander Zheleznyak, Joel R. Garbow, Michal Neeman, Suzanne E. Lapi

“…Hypoxic placentas and fetuses retained more 64 Cu-ATSM compared to normoxic placentas and fetuses. …”
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Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E2 and F2α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Di... by Hisham Y. Al-Matubsi, Ghaleb A. Oriquat, Mahmoud Abu-Samak, Othman A. Al Hanbali, Maher D. Salim

“…Decreased levels of PGEM and elevated levels of PGFM in the fetuses, placentas, and membranes were characteristic of experimental diabetic gestation associated with malformation. …”
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A Prospective Study of Villous Capillary Lesions in Complicated Pregnancies by Anu Priyadharshini Srinivasan, B. O. Parijatham Omprakash, Kandhimalla Lavanya, Priyadharshini Subbulakshmi Murugesan, Saraswathi Kandaswamy

“…In this study, we attempted to identify villous vascular changes in a group of term placentae from mothers with diseases complicating pregnancy. …”
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Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia by Alejandra María Gómez-Gutiérrez, Beatriz Elena Parra-Sosa, Julio Cesar Bueno-Sánchez

“…To examine the expression of hypoxia-inducible factor-1α (HIF-1α), TfR1, and TfR1-attached terminal monosaccharides in placentas of women with IDAP and severe preeclampsia. …”
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Placental Pathology and Blood Pressure’s Level in Women with Hypertensive Disorders in Pregnancy by Vassiliki Krielessi, Nikos Papantoniou, Ioannis Papageorgiou, Ioannis Chatzipapas, Efstathios Manios, Nikos Zakopoulos, Aris Antsaklis

“…Vessels number was significantly decreased, and infarction and villous fibrinoid necrosis were significantly increased in the placentas of the severe hypertension group compared to the mild hypertension group (𝑃<0.001). …”
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Umbilical Coiling Index as a Marker of Perinatal Outcome: An Analytical Study by T. Chitra, Y. S. Sushanth, S. Raghavan

“…Hypocoiling (<0.12) was found to be significantly associated with hypertensive disorders, abruptio placentae, preterm labour, oligohydramnios, and fetal heart rate abnormalities. …”
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11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia by Katarzyna Kosicka, Anna Siemiątkowska, Franciszek K. Główka

“…The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. …”
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Prevalence of Brucellosis among Women Presenting with Abortion/Stillbirth in Huye, Rwanda by Nadine Rujeni, Léonidas Mbanzamihigo

“…More mechanistic studies will also demonstrate the pathogenicity of Brucella in human placentas.…”
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Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance by Zengfang Wang, Ruizhen Yang, Jiaojiao Zhang, Pingping Wang, Zengyan Wang, Jian Gao, Xue Liu

“…Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. …”
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Antioxidant Capacity and Total Phenolic Content in Fruit Tissues from Accessions of Capsicum chinense Jacq. (Habanero Pepper) at Different Stages of Ripening by Lizbeth A. Castro-Concha, Jemina Tuyub-Che, Angel Moo-Mukul, Felipe A. Vazquez-Flota, Maria L. Miranda-Ham

“…The antioxidant capacity of Capsicum was directly related to the total amount of phenolic compounds detected. In particular, placentas had high levels of capsaicinoids, which might be the principal responsible for their strong antioxidant activities.…”
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PPAR-γ Regulates Trophoblast Differentiation in the BeWo Cell Model by Khrystyna Levytska, Sascha Drewlo, Dora Baczyk, John Kingdom

“…Common pregnancy complications, such as severe preeclampsia and intrauterine growth restriction, disrupt pregnancy progression and impair maternal and fetal wellbeing. Placentas from such pregnancies exhibit lesions principally within the syncytiotrophoblast (SCT), a layer in direct contact with maternal blood. …”
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The Impact of PTPRK and ROS1 Polymorphisms on the Preeclampsia Risk in Han Chinese Women by Huihui Li, Xingyu Yan, Man Yang, Mei Liu, Shan Tian, Mengru Yu, Wei-Ping Li, Cong Zhang

“…Both qPCR and Western blotting were utilized to investigate the levels of PTPRK in placentas of 20 PE and 20 normal pregnancies. Results. …”
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Red Light Mitigates the Deteriorating Placental Extracellular Matrix in Late Onset of Preeclampsia and Improves the Trophoblast Behavior by Jakara Griffin, John G. Krolikowski, Kenisha Kounga, Janine Struve, Agnes Keszler, Brian Lindemer, Michelle Bordas, Grant Broeckel, Nicole L. Lohr, Dorothee Weihrauch

“…Since NO is critical for placentation, we examined eNOS activity in preeclamptic placentas compared to healthy ones and found no differences; however, 670 nm light treatment triggered enhanced NO availability presumably by using alternative NO sources. …”
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Incidence and Characterization of the Hypertensive Disorders during Pregnancy by María Pérez Hernández, Viviana Sáez Cantero, Gonzalo Aguero Alfonso, Hortensia González García, Antonio Alfonso Dávila, Felicia Vilches Luis

“…Predominating conditions were primiparity in patients with eclampsia (100 %), pre-eclampsia (75 %) and transitory hypertension (74, 6 %); cesarean and abruptio placentae in patients with pre-eclampsia/eclampsia and the admission at the intensive care of patients with eclampsia (75 %). …”
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Differential Expression of Placental Glucocorticoid Receptors and Growth Arrest-Specific Transcript 5 in Term and Preterm Pregnancies: Evidence for Involvement of Maternal Stress by D. Mparmpakas, E. Zachariades, G. Sotiriadis, A. Goumenou, A. J. Harvey, Y. Gidron, E. Karteris

“…GAS5 and GRα were the predominant transcripts in both term and preterm placentas, with GAS5 being primarily localized in the syncytiotrophoblasts. …”
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Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection-A scoping review. by Janelle Y Wai, Eilidh M Wood, Kylie K Hornaday, Donna M Slater

“…SARS-CoV-2 infection was associated with perturbations in the ACE2 pathway, inflammatory mediators and immune cell populations and mitochondrial function in placentas.<h4>Conclusions</h4>Our findings suggest that changes in the ACE2 pathway, mitochondrial dysfunction, and/or inflammatory processes may lead to placental damage observed in SARS-CoV-2 infection during pregnancy. …”
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Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications by Yurong Chen, Haibo Zhu, Fucheng Guo, Luyao Wang, Wenli Zhang, Ruizhi Liu, Xiaoling Zhang, Xiangpeng Dai

“…Moreover, vitrification significantly altered transcriptome profiles of mice placentas and brains at embryonic day 18.5 (E18.5). …”
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C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation by Yongfeng Hu, Shaoqiang Li, Yunhui Hong, Dongxian Peng

“…Reduced C3AR1 in preeclamptic placentas correlated with maternal blood pressure, and showed high diagnostic potential (AUC = 0.95). …”
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