Components of cognitive–behavioural therapy for mitigating core symptoms in attention-deficit hyperactivity disorder: a systematic review and network meta-analysis by Sayo Hamatani, Kazuki Matsumoto, Yoshihiko Kunisato, Yoshifumi Mizuno

“…Third-wave therapy (OR=4.80, 95% credible interval (CrI) 2.50 to 9.10), behaviour therapy (OR=3.50, 95% CrI 1.70 to 7.30) and CBT (OR=3.10, 95% CrI 1.70 to 5.70) were treatments that demonstrated superior efficacy compared with placebo. The component-level analyses showed organisational strategies (incremental OR (iOR)=2.03, 95% CI 1.27 to 3.24) and third-wave components (iOR=1.95, 95% CI 1.30 to 2.93) were associated with increase in treatment response. …”
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NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…A safety profile and tolerability of daclatasvir is good, comparable to placebo group. The drug is not registered in Russia yet, its approval in combination to asunaprevir is expected soon.Conclusion. …”
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Effect of Fentanyl as an Adjuvant to Brachial Plexus Block for Upper Extremity Surgeries: A Systematic Review and Meta-Analysis of RCTs by Liangsong Song, Shulian Tan, Qingmin Chen, He Li

“…We explore the PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar databases for all randomized controlled trials (RCTs) comparing adjuvant fentanyl with placebo/no drug for patients undergoing upper extremity surgery under brachial plexus block. …”
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Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The combination of faldaprevir to interferon and ribavirin has essentially increased efficacy of treatment at previously untreated patients with hepatitis C genotype 1 (according to results of SILEN-C1 study, frequency of SVR achievement was 82% in group receiving faldaprevir in comparison to 56% of patients, who received placebo). Addition of faldaprevir to treatment mode has allowed to increase frequency of SVR (to 50%) in patients with unsuccessful course of standard antiviral therapy. …”
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Safety and Phosphate‐Binding Capacity of Oxylanthanum Carbonate in Healthy Volunteers by Pablo E. Pergola, Melanie S. Joy, Armando Garsd, Steve J. Hasal, Atul Khare, Guru Reddy, Pramod Gupta, William F. Finn

“…In a double‐blind dose‐escalation phase 1 study, healthy volunteers (n = 32) were randomly divided into four treatment arms and randomly assigned to receive oxylanthanum carbonate tablets or a placebo over a period of 4 days to evaluate safety, urinary and fecal excretion of phosphorus, and pharmacokinetics. …”
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Inhaled corticosteroids' effect on COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials by Yasra Badi, Mohamed Hammad, Abdelrahman G. Tawfik, Mona Muhe Eldeen Eshag, Mahmoud M. Elhady, Khaled Mohamed Ragab, Anas Zakarya Nourelden, Mohamed Hesham Gamal, Ahmed Hashem Fathallah

“…Our study showed a significant decrease in the LOS in ICS patients over placebo (MD = -1.52, 95% CI \[-2.77 to -0.28\], *p-value* = 0.02). …”
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Prophylactic antibiotics in laparoscopic cholecystectomy: Reducing postoperative infection risk–A meta-analysis and trial sequential analysis by Shufeng Wang, Qing Gao, Xiaogang Qi, Lihua Hong, Hai Huang

“…RCTs comparing prophylactic antibiotics versus placebo or no treatment in patients undergoing laparoscopic cholecystectomy were included. …”
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Effectiveness of 4 weeks of electrical vestibular stimulation in the management of temporomandibular pain by Yashica Gowda R, Asha G, Doreswamy Kanakaiah, Karthik N, Sai Sailesh Kumar Goothy, Mukkadan JK

“…The intervention group received electrical vestibular nerve stimulation for 4 weeks and regular treatment as an adjunctive therapy. Placebo stimulation was administered to the control group along with the regular treatment. …”
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Intra-Articular Injection of Human Bone Marrow–Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial by Bong-Woo Lee, Jennifer Jooha Lee, Joon-Yong Jung, Ji Hyeon Ju

“…To assess the impact of a single intra-articular (IA) injection of bone marrow–derived mesenchymal stem cells (BM-MSCs) in patients with knee osteoarthritis (OA), a randomized, double-blind, placebo-controlled study was conducted. The study included 24 patients with knee OA who were randomly assigned to receive either a single IA injection of BM-MSCs or normal saline. …”
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Issues of diagnostics and treatment of abdominal pain at irritable bowel syndrome at outpatient stage of the healthcare by Yu. A. Kucheryavy, T. L. Lapina, M. A. Livzan, M. F. Osipenko

“…The rate of adverse events and tolerability of hyoscine butylbromide are comparable to that of placebo.Conclusion. Symptomatic treatment by antispasmodic drugs is justified from the moment of referral for medical aid to outpatient department. …”
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Efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial by Jianxin Jiang, Jimin Wu, Shuqi Shi, Xiaoli Dong, Jiaxiang Yin, Yini Wu

“…Methods In this prospective trial one hundred and sixty general anesthesia surgery patients (20 to 60 years) using laryngeal mask airway were randomly divided into control group (Group C, saline as placebo), lidocaine gel group (Group LG, lidocaine gel applied to the surface of the laryngeal mask), single intravenous lidocaine group (Group SL, intravenous lidocaine 1.5 mg/kg at induction of anesthesia) and continuous infusion of lidocaine group (Group CL, a bolus of 1.5 mg/kg, followed by an infusion of 2 mg/kg/h until the end of the surgical). …”
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Effect of a virtual walking and exercise-based intervention on muscle strength and activation in people with incomplete spinal cord injury by Sara Mollà-Casanova, Elena Muñoz-Gómez, Noemí Moreno-Segura, Marta Inglés, Marta Aguilar-Rodríguez, Núria Sempere-Rubio, Pilar Serra-Añó

“…Abstract This study aims to assess the effect of combining virtual walking (VW) therapy with a physical exercise (PE) program compared to PE alone on lower limb strength and muscle activation in people with incomplete spinal cord injury (iSCI). 38 participants performed 3 sessions/week during 6 weeks of Experimental Intervention (EI): VW and PE; or Control intervention (CI): Placebo-VW and PE. Strength and muscle activation of main lower limb muscles were assessed. …”
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Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention... by Yingying Luo, Sanjoy K. Paul, Xianghai Zhou, Cuiqing Chang, Wei Chen, Xiaohui Guo, Jinkui Yang, Linong Ji, Hongyuan Wang

“…Participants diagnosed as prediabetes were randomized into four groups (conventional/intensive lifestyle intervention and 30 mg pioglitazone/placebo) with a three-year follow-up. The primary endpoint was conversion into normal glucose tolerance. …”
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The efficacy of acupuncture in relieving postoperative pain in patients with low simple anal fistula: Protocol of a prospective, randomised, controlled trial. by Min Yang, De Zheng, Xingtao Jin, Huili Tang, Weiwei Cao, Qianqian Ye, Yin Qu, Zubing Mei

“…<h4>Methods</h4>This single-centre, patient-blinded, assessor-blinded, placebo-controlled randomised controlled trial (RCT) will be conducted at a tertiary referral hospital. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…Methods In this article, we describe the rationale and design of the Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE) study, a double-blinded intervention in which 80 participants over 45 years of age with knee osteoarthritis pain will be recruited to participate in a cross-over trial of 4 weeks of intranasal oxytocin or placebo administration. Primary study outcomes include preliminary changes in pain intensity and interference as well as multi-modal assessment batteries including circulating biomarkers and neuroimaging measures. …”
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Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect by Swetha Reddi, Liliia Senyshyn, Maryam Ebadi, Daniel Podlesny, Samuel S. Minot, Ted Gooley, Amanda J. Kabage, Geoffrey R. Hill, Stephanie J. Lee, Alexander Khoruts, Armin Rashidi

“…We designed a randomized, double-blind placebo-controlled trial to test whether healthy-donor fecal microbiota transplantation (FMT) early after alloHCT reduces the incidence of severe aGVHD. …”
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Mesenchymal Stem Cell-Educated Macrophages Ameliorate LPS-Induced Systemic Response by Yaoqin Hu, Chaojin Qin, Guoping Zheng, Dengming Lai, Huikang Tao, Yan Zhang, Guanguan Qiu, Menghua Ge, Lanfang Huang, Lina Chen, Baoli Cheng, Qiang Shu, Jianguo Xu

“…When macrophages were cultured with serum from ARDS patients who were treated with ASCs or placebo in our previous clinical trial, there was no difference in M2 macrophage levels before and after ASCs treatment indicating a suboptimal response to the treatment protocol. …”
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Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical... by Maryam Asadi, Fatemeh Haidari, Hossein Bavi Behbahani, Maryam J Chitsazi, Javad Mohammadi-asl, Kambiz Ahmadi-Angali

“…Methods: Participants were randomly assigned to two groups: a standard weight-loss group receiving 3 g/day of Tau capsules for 8 weeks (n=20) and a standard weight-loss group receiving placebo capsules for 8 weeks (n=18). The weight loss intervention aimed to reduce 30% of the total energy consumed by the participants.A paired t-test and an independent sample t-test were employed to assess parametric continuous data within and between the groups. …”
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Hydrocortisone for Preventing Adverse Drug Reactions to Snake Antivenom: A Meta-Analysis by Jihua Feng, Zimeng Wu, Qiao Yu, Hongyuan Li, Pan Ji, Yanli Yang, Xiaoliang Zeng, Xiaowen Zheng, Chunling Zhao, Jianfeng Zhang

“…Premedications, including hydrocortisone with or without other drugs, were compared with placebo or no premedication. Our primary end point was the risk of ADRs, which was reported as the number of patients who developed ADRs divided by the total number of snakebite patients administered with antivenom separately for the prehydrocortisone and control groups for each study. …”
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Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials by Chang Meng, Duo Wang, Yue Zhao, Jing Sun, Guobin Miao, Lijuan Chen, Ying Bai, Peng Liu

“…In terms of other end events, length of intensive care unit(ICU) stay(MD -0.16, 95%CI -1.85-1.53, I2 = 0%, P = 0.85) and mortality(OR 1.59, 95%CI 0.74–3.42, I2 = 0%, P = 0.23) were not statistically different with dexmedetomidine compared with placebo. Bradycardia (OR 0.85, 95%CI 0.54 ~ 1.34, I2 = 72%, P = 0.49) and hypotension (OR 1.97, 95%CI 0.96 ~ 4.03, I2 = 84%, P = 0.06) were not significantly different between the two groups. …”
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