Efeitos do Orforglipron no tratamento da obesidade by Marcelo José da Silva de Magalhães, Pedro Henrique Martins de Souza, Victória Toledo Oliva Ferreira Silva

“…Foi avaliada a perda de peso absoluta por meio do uso do Orforglipron dose de 45 mg diária versus placebo. Resultados: foram selecionados cinco ensaios clínicos randomizados. …”
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Feasibility of Cognitive Training in Combination With Transcranial Direct Current Stimulation in a Home-Based Context (TrainStim-Home): study protocol for a randomised controlled t... by Ulrike Grittner, Agnes Flöel, Rafal Nowak, Friederike Thams, Daria Antonenko, Merle Rocke, Robert Malinowski

“…With this study, we aim to provide evidence for the feasibility and the effects of a multisession home-based cognitive training in combination with tDCS on cognitive functions of healthy older adults.Methods and analysis The TrainStim-Home trial is a monocentric, randomised, double-blind, placebo-controlled study. Thirty healthy participants, aged 60–80 years, will receive 2 weeks of combined cognitive training and anodal tDCS over left dorsolateral prefrontal cortex (target intervention), compared with cognitive training plus sham stimulation. …”
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Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models by Alexander J. Szalai, Mark A. McCrory, Dongqi Xing, Fadi G. Hage, Andrew Miller, Suzanne Oparil, Yiu-Fai Chen, Michelle Mazzone, Richard Early, Scott P. Henry, Thomas A. Zanardi, Mark J. Graham, Rosanne M. Crooke

“…CRP specific ASOs might pave the way towards a placebo-controlled trial that could clarify the role of CRP in cardiovascular disease.…”
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Comparing apples and oranges in youth depression treatments? A quantitative critique of the evidence base and guidelines by Samuele Cortese, Glyn Lewis, Argyris Stringaris, Georgina Krebs, Marinos Kyriakopoulos, Lucy Foulkes, Carmen Moreno, Charlotte Burman, Raphaelle Delpech, Rudolph Uher, Dayna Bhudia, Despoina Miliou, Ioannis-Marios Rokas

“…There was a dramatic difference in the within-subject improvement due to placebo (SMD=−1.9 (95% CI: −2.1 to −1.7)) vs. psychotherapy controls (SMD=−0.6 (95% CI: −0.9 to −0.3)). …”
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Admission Hyperglycemia and Acute Myocardial Infarction: Outcomes and Potential Therapies for Diabetics and Nondiabetics by Anjan K. Chakrabarti, Priyamvada Singh, Lakshmi Gopalakrishnan, Varun Kumar, Meagan Elizabeth Doherty, Cassandra Abueg, Weici Wang, C. Michael Gibson

“…There is now a need for a large placebo-controlled randomized trial with an adequate sample size and adherence to glucose targets in order to establish the benefit of treating hyperglycemia in patients presenting with AMI.…”
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Carbohydrate Restriction During Recovery from High-Intensity–Interval Training Enhances Fat Oxidation During Subsequent Exercise and Does Not Compromise Performance When Combined W... by Camilla Soegaard, Simon Riis, Jesper Friis Mortensen, Mette Hansen

“…Methods: By using a randomized, double-blinded, placebo-controlled, crossover design, 17 female endurance athletes completed 3 experimental blocks. …”
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Economic Evaluation of a Novel Treatment of Attention-Deficit/Hyperactivity Disorder in US Motor Vehicle Drivers by Jacie T. Cooper, John E. Schneider, Jim Potenziano, David S. Fam

“…A randomized controlled trial showed that DXR patients were 43% less likely to crash during a driving simulation than individuals taking placebo. Study outcomes suggest a DXR crash rate similar to that of a driver without ADHD, while patients treated with the current standard of care (SOC) have a 52% higher crash risk than non-ADHD drivers. …”
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The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment by Yilmaz Ozbay, Mehmet Akbulut, Mehmet Balin, Hidayet Kayancicek, Adil Baydas, Hasan Korkmaz

“…We think that hs-CRP measurement may be a good prognostic value in CAE patients as in stenotic ones. Further placebo-controlled studies are needed to evaluate the clinical significance of this decrease in hs-CRP.…”
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Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…However, the success of placebo-controlled clinical trials has been limited, so new ways of improving the therapeutic effects of MSC are being developed, such as their assembly in a 3D conformation. …”
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Efficacy of Hot Tea Infusion vs. Ethanolic Extract of Moringa oleifera for the Simultaneous Treatment of Nonalcoholic Fatty Liver, Hyperlipidemia, and Hyperglycemia in a Murine Mod... by Salma I. Cortes-Alvarez, Ivan Delgado-Enciso, Alejandrina Rodriguez-Hernandez, Gustavo A. Hernandez-Fuentes, Nomely S. Aurelien-Cabezas, Norma A. Moy-Lopez, Nadia Y. Cortes-Alvarez, Jorge Guzman-Muñiz, Jose Guzman-Esquivel, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Karen A. Mokay-Ramirez, Carlos E. Barajas-Saucedo, Carmen A. Sanchez-Ramirez

“…A significant reduction of SGPT, SGOT, lipids, urea, and glucose in blood among NAFLD groups treated with MO (infusion or extract) was found, when compared to the NAFLD-placebo group. Steatosis and liver inflammation were found to be decreased in the MO groups, as infusion or ethanolic extract. …”
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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI. …”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…The ALS responses were vaccine-specific since no responses were detected among placebo recipients at any time. A strong correlation and agreement between responders/non-responders were noted between ALS and other mucosal (ASC and fecal IgA) and systemic (serum antibody) immune responses. …”
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Effect of Dipeptidyl Peptidase-4 (DPP-4) Inhibition on Biomarkers of Kidney Injury and Vascular Calcification in Diabetic Kidney Disease: A Randomized Controlled Trial by Thananda Trakarnvanich, Bancha Satirapoj, Swangjit Suraamornkul, Thanit Chirananthavat, Anoma Sanpatchayapong, Torpong Claimon

“…This study employed a multicenter, prospective, randomized, placebo-controlled design. A total of 201 participants were enrolled and randomly assigned to one of two groups, one received treatment with 50 mg gemigliptin daily along with standard care for diabetes mellitus for 6 months. …”
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Comparative Evaluation of Efficacy of Chlorhexidine and Herbal Mouthwash as a Preprocedural Rinse in Reducing Dental Aerosols: A Microbiological Study by Sangeeta Umesh Nayak, Anushka Kumari, Valliammai Rajendran, Vijendra Pal Singh, Ashwini Hegde, Keshava K. Pai

“…This was a single-center, double-masked, placebo-controlled, randomized, three-group parallel design study. 30 patients (10 patients in each group) were recruited in the study. …”
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Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer’s Disease: A Systematic Review by Joanna Campbell, Louis Lavoie, Mariana Farraia, Rachel Huelin, Quanwu Zhang, Amir Abbas Tahami Monfared

“…Interventions were generally associated with smaller declines in PROs compared to placebo, suggesting a positive impact of treatment in mitigating QoL deterioration. …”
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Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial by Rolf Wachter, Sanjiv J. Shah, Martin R. Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske

“…BMIC includes (i) enalapril, (ii) valsartan, and (iii) placebo depending on the type of medical therapy prior to enrolment. …”
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Safety, Immunogenicity, and Efficacy of Cytomegalovirus Vaccines: A Systematic Review of Randomized Controlled Trials by Manuela Chiavarini, Anita Genga, Giorgia Maria Ricciotti, Marcello Mario D’Errico, Pamela Barbadoro

“…<b>Methods</b>: According to the PRISMA guidelines (PROSPERO ID: CRD42024516601), a comprehensive literature search was conducted to identify all the randomized controlled trials that have evaluated the safety, immunogenicity, and efficacy of vaccine candidates compared to a placebo. A total of 26 studies were identified: 11 on transplant patients and 15 on healthy individuals. …”
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Therapeutic effects of acupuncture therapy for kidney function and common symptoms in patients with chronic kidney disease: a systematic review and meta-analysis by Shan Liu, Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

“…This systematic review and meta-analysis aim to examine the therapeutic role of acupuncture therapy in kidney function and common symptoms in CKD patients.Methods We searched Embase, PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, WanFang, and WeiPu for randomized controlled trials comparing acupuncture treatment with control or placebo groups. We assessed the effect of acupuncture therapy in CKD patients using a meta-analysis with the hartung-knapp-sidik-jonkman random effects model. …”
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Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Literature supports the intraoperative use of lidocaine infusions to decrease postoperative opioid requirements, however, whether the use of postoperative lidocaine infusions is associated with lower opioid requirements and subsequently a reduction in postoperative delirium has not been investigated.Methods and analysis The Lidocaine Infusion for the Management of Postoperative Pain and Delirium trial is a randomised, double-blinded study of a postoperative 48-hour infusion of lidocaine at 1.33 mg/kg/hour versus placebo in older patients undergoing major reconstructive spinal surgery at the University of California, San Francisco. …”
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Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility by Xiaomei Jiang, Yongfeng Wang, Hong Tang, Jin Ma, Heyue Li

“…Over a two-month study period, the control group received light fasting diet therapy with rice flour as a placebo, while the intervention group received light fasting diet therapy supplemented with flaxseed powder. …”
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