Whole-body photobiomodulation therapy for chronic pain: a protocol for a feasibility trial by Nicola R Heneghan, Andrew Soundy, Bethany Fitzmaurice, Asius Rayen

“…Research is needed to consider the feasibility of this device.Methods and analysis A single-centre single-armed (no placebo group) feasibility study with an embedded qualitative component will be conducted. …”
Get full text

Transcutaneous Electrical Nerve Stimulation Integrated into Pants for the Relief of Postoperative Pain in Hip Surgery Patients: A Randomized Trial by Yohann Opolka, Courage Sundberg, Robin Juthberg, Amelie Olesen, Li Guo, Nils-Krister Persson, Paul W. Ackermann

“…The effect of transcutaneous electrical nerve stimulation (TENS) on pain and impression of change was assessed during a 2.5-hour intervention on the first postoperative days following hip surgery in a randomized, single-blinded, placebo-controlled trial involving 30 patients. Methods. …”
Get full text

Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial by Hong Ding, Shu Liu, Ke-Xin Zhao, Jie Pu, Ya-Fei Xie, Xiao-Wei Zhang

“…Comparative studies on the efficacies of two or more antihypertensive agents or placebos for hypertensive patients were included. The outcomes were variations in mean systolic and diastolic blood pressure. …”
Get full text

Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study by Majid Shohrati, Mostafa Ghanei, Asghar Amini Harandi, Soniya Foroghi, Ali Amini Harandi

“…In a double-blind clinical trial study, 40 patients with documented history of exposure to SM were allocated to two groups: group 1 who received 1 mg morphine sulfate diluted by 4 cc normal saline 0.5% using nebulizer once daily for 5 days and group 2 serving as control who received normal saline as placebo. They were visited by pulmonologist 7 times per day to check symptoms and signs and adverse events. …”
Get full text

Effect of pasak bumi (Eurycoma longifolia Jack), DHA, and seluang fish (Rasbora spp.) on neuroinflammation and neurotransmitter alterations in malnourished rats by Triawanti, Didik Dwi Sanyoto, Meitria Syahadatina Noor, Dimas Ikhsan Airlangga

“…Methods: The study involved dividing malnourished rats into six experimental groups: (1) untreated control, (2) treated with pasak bumi extract, (3) treated with DHA, (4) treated with a combination of DHA and pasak bumi extract, (5) treated with seluang fish, (6) treated with a combination of seluang fish and pasak bumi extract; and a control group of normal rats receiving standard feed and placebo. The primary outcomes measured were levels of IL-6, TNF-α, and serotonin. …”
Get full text

Research status of east Asian traditional medicine treatment for chronic cough: A scoping review. by Boram Lee, Chan-Young Kwon, Ye Ji Kim, Jae Hyun Kim, Kwan-Il Kim, Beom-Joon Lee, Jun-Hwan Lee

“…In addition, high-quality studies assessing the efficacy of EATM with placebo control treatment should be conducted, using validated evaluation tools.…”
Get full text

Engagement in a web-based intervention for individuals who committed sexual offenses against children: observational study by Sonja Schröder, Safiye Tozdan, Peer Briken, Jürgen L. Müller, Peter Fromberger

“…Using data from an intermediate analysis of the randomized placebo-controlled clinical trial to evaluate the effectiveness of @myTabu, the current study investigated engagement with a web-based intervention for 113 individuals convicted of child sexual abuse and/or for child sexual exploitation material. …”
Get full text

Formulation Design of Orally Disintegrating Film Using Two Cellulose Derivatives as a Blend Polymer by Yoshiko Takeuchi, Fumika Hayakawa, Hirofumi Takeuchi

“…This study aimed to investigate the utility of hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC) as blend film-forming components for ODFs. <b>Methods</b>: Placebo ODFs were prepared using polymer mixtures with blend ratios ranging from 20% to 80% HPC with HPMC. …”
Get full text

Cumulative incidence and risk of infection in patients with rheumatoid arthritis treated with janus kinase inhibitors: A systematic review and meta-analysis. by Konstantinos Ouranos, Diana V Avila, Evangelia K Mylona, Athanasios Vassilopoulos, Stephanos Vassilopoulos, Fadi Shehadeh, Eleftherios Mylonakis

“…The PubMed and EMBASE databases were queried for randomized controlled trials comparing patients with RA treated with JAKi (upadacitinib, baricitinib, tofacitinib, peficitinib, or filgotinib), defined as the treatment group, compared with control subjects, defined as participants receiving placebo or treatment regimen that was similar to that of participants in the treatment group, with the exception of JAKi. …”
Get full text

Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…From the 15th to the 18th week, the animals received treatment—through orogastric gavage—with placebo or free capybara oil (5 g/kg). Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. …”
Get full text

Sustained response off treatment after fostamatinib in refractory immune thrombocytopenia: A series of four case reports by Waleed Ghanima, Francisco Javier Lucas Boronat, Valentina Carrai, Stefan Rackwitz

“…He was pre-treated with prednisone and rituximab before being in the FIT-2 clinical trial (placebo). He received fostamatinib in the FIT-3 open-label extension for seven weeks and maintained SROT for 2.5 years. …”
Get full text

Acupuncture in the Treatment of a Female Patient Suffering from Chronic Schizophrenia and Sleep Disorders by Peggy Bosch, Sabina Lim, Sujung Yeo, Sook-Hyun Lee, Heike Staudte, Maurits van den Noort

“…In sum, this study showed that acupuncture might be beneficial in the treatment of sleep disorders in patients suffering from chronic schizophrenia, but future, large, randomized (placebo), controlled, clinical trials are needed in order to replicate the present preliminary findings.…”
Get full text

Optimized Naive-Bayes and Decision Tree Approaches for fMRI Smoking Cessation Classification by Amirhessam Tahmassebi, Amir H. Gandomi, Mieke H. J. Schulte, Anna E. Goudriaan, Simon Y. Foo, Anke Meyer-Baese

“…One class took the drug N-acetylcysteine and the other class took a placebo. Then, the patients underwent a double-blind smoking cessation treatment and the resting-state fMRI scans of their brains before and after treatment were recorded. …”
Get full text

Kinesiology Tape: A Descriptive Survey of Healthcare Professionals in the United States by Scott W Cheatham, Russell T Baker, Thomas E Abdenour

“…Some respondents believed KT only created a placebo effect (40%) and use it for such therapeutic purposes (58%). …”
Get full text

Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca by Verónica Mujica, Roxana Orrego, Roberto Fuentealba, Elba Leiva, Jessica Zúñiga-Hernández

“…This was evaluated in a randomized placebo-controlled study of subjects receiving care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca, Chile. …”
Get full text

Changes in Serum TSH and T4 Levels after Switching the Levothyroxine Administration Time from before Breakfast to before Dinner by S. Ala, O. Akha, Z. Kashi, A. Bahar, H. Askari Rad, N. Sasanpour, A. Shiva

“…Each group received two tablets per day (one levothyroxine tablet and one placebo tablet) 30 minutes before breakfast and 1 hour before dinner. …”
Get full text

Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…**Background:** Recent international, randomized, placebo-controlled clinical trials (SPRINT-2; RESPOND-2) demonstrated that the triple combination of peginterferon (PEG), ribavirin (RBV) and boceprevir (BOC) was more efficacious than the standard dual therapy of PEG and RBV in treatment of patients chronically infected with genotype 1 hepatitis C virus (HCV) infection. …”
Get full text

Four Weeks of Inspiratory Muscle Training Improves Self-Paced Walking Performance in Overweight and Obese Adults: A Randomised Controlled Trial by A. M. Edwards, G. P. Maguire, D. Graham, V. Boland, G. Richardson

“…A total of 15 overweight and obese adults were randomized into experimental (EXP: 𝑛=8) and placebo (PLA: 𝑛=7) groups. Lung function, inspiratory muscle performance, 6-minute walking test, and predicted ̇VO2 max were assessed prior to and following the 4-week IMT intervention. …”
Get full text

The Role of the Gastrointestinal Microbiota in Parkinson’s Disease by Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti, Antonio Gasbarrini

“…Rigorous, large-scale, randomized placebo-controlled trials with standardized treatments in terms of composition, dosage, and duration are urgently needed to validate these findings and pave the way for microbiota-based therapeutic strategies in PD management.…”
Get full text

Virtual reality head-mounted display game for intermittent exotropia in a randomized controlled trial by Hee Kyung Yang, Dong Hyun Kim, Je Hyun Kim, Taeg Keun Whangbo, Jeong-Min Hwang

“…Patients were randomly assigned to a video-game group that induced convergence (exercise group) and a placebo-game group not inducing convergence (control group), and completed the program 15 min/day for 4 weeks. …”
Get full text