Still No Substantial Evidence to Use Prophylactic Antibiotic at Operative Vaginal Delivery: Systematic Review and Meta-Analysis by Yifru Berhan, Sisay Kirba, Achamyelesh Gebre

“…In the included randomized trial, 97% of the study participants had perineal wound for whom repairs were performed; the risks of maternal infection and perineal wound breakdown were comparable, and maternal infections other than perineal wound infection did not show significant difference between prophylactic antibiotic and placebo groups. The majority of included studies demonstrated a strong association of postpartum infection and perineal wound dehiscence with episiotomy and perineal tear. …”
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Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study by Jayant Deshpande, Shankaranarayanan Jeyakodi, Vijaya Juturu

“…The study was to evaluate the safety and tolerability of the capsaicinoids (CAPs) from Capsicum extract in a beadlet form compared to placebo in a healthy overweight population. The investigational product capsaicinoids (CAPs) from Capsicum extract in a beadlet form (Capsimax®) a proprietary encapsulated form of Capsicum extract in beadlet form supplemented at 2 mg, 4 mg, 6 mg, 8 mg and 10 mg of CAPs. …”
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Management of hepatorenal syndrome and associated outcomes: a systematic review by Anahid Hamidianjahromi, Jamshid Roozbeh, Shahrokh Ezzatzadegan Jahromi, Mohamad Hossein Rezazadeh, Leila Malekmakan

“…Of which 24 articles were conducted on terlipressin versus placebo or other treatments (midodrine/octreotide, norepinephrine, etc) that showed the higher rate of HRS reversal was detected for terlipressin in 17 studies (10 of them were significant), 2 studies achieved an insignificant lower rate of the model for end-stage liver disease score for terlipressin, 15 studies showed a decreased mortality rate in the terlipressin group (4 of them were significant).Conclusion This review showed that terlipressin has a significantly higher reversal rate of HRS than the other treatments. …”
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The efficacy of parasacral transcutaneous electrical nerve stimulation for the treatment of overactive bladder in children: a systematic review and meta-analysis by Zhuoqi Cheng, Yumeng Chai, Zhongbao Zhou, Yong Zhang

“…From the literature review, eight RCTs (351 participants) comparing PTENS and other treatments (standard urotherapy/anticholinergics/biofeedback/placebo stimulation) were considered.ResultsThe overall complete response rate with PTENS was 1.90 times that of children undergoing other treatment (relative risk 1.90, 95% confidence interval 1.45–2.49). …”
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Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

“…To estimate efficacy and safety of narlaprevir (NVR) with ritonavir (RTV), pegilated interferon (peg-IFN) and ribavirin (RBV) at treatmentnaïve and earlier treated noncirrhotic patients with chronic hepatitis C caused by the 1st virus genotype in double blind placebo-controlled 3rd phase study (PIONEER). Material and methods. …”
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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

“…Methods Participants were randomized 1:1 to either active cabotegravir (CAB) plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) placebo or active TDF/FTC plus CAB placebo. Pregnancy testing was performed at each visit; participants with a positive test had study product withheld and were offered open‐label TDF/FTC. …”
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Ethanolic extract of black soldier fly (Hermetia illucens L.) larvae for wound healing in mice (Mus musculus L.) by Darman Agung Sandakila, Gracetia Devita Hadi, Riska Gultom, Seni Samalele, Rudy Agung Nugroho

“…Using a completely randomized design, 30 male mice were divided into 6 treatment groups: no treatment (K-1), placebo (K-2), povidone iodine 10% (K+), and BSFL ethanolic extract at 10%, 15%, and 20% concentrations. …”
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Response Rate and Impact on Lipid Profiles of Obeticholic Acid Treatment for Patients with Primary Biliary Cholangitis: A Meta-Analysis by Yuan Gao, Li Li, Bei Li, Yutao Zhan

“…Three trials, with 265 patients, were selected for the analysis. OCA was superior to placebo in PBC patients (RR, 1.48; 95% CI, 1.15–1.90). …”
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The effect of gonadotropin-releasing hormone or human chorionic gonadotropin administration at mating on lambing performance in konya merino yearling ewes by Mehmet Köse, Ahmet Hamdi Aktaş, Mesut Kırbaş, Bülent Bülbül

“…Group I (n=14) were injected 200 IU hCG, Group II (n=12) were injected 4 μg GnRH, and Group III (control group, n=10) were injected 1 mL placebo at mating. Pregnancy was diagnosed on day 30 by using transrectal ultrasonography.…”
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The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials by Hong Gao, YanTao Li, WenNan Yan, Fei Gao

“…The results of the meta-analysis showed that, compared with placebo, vitamin D supplementation can significantly reduce total cholesterol level (WMD = –11.32, 95% CI = [–14.51, –8.41], P<0.00001), low-density lipoprotein cholesterol level (WMD = –4.83, 95% CI = [–7.52, –2.14], P=0.0004), and triglyceride level (WMD = –8.23, 95% CI = [–13.08, –3.38], P=0.0009, but the effect on high-density lipoprotein cholesterol level is not statistically significant (WMD = –0.32, 95%CI = [–1.24, 0.60], P=0.50). …”
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Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2... by Asdar Gani, Risfah Yulianty, Supiaty Supiaty, Machirah Rusdy, Gustivanny Dwipa Asri, Dian Eka Satya, Ayu Rahayu Feblina, Harun Achmad

“…Then the femoral bone defect was made, the positive control group was given placebo gel, the positive control group was given BATAN hydroxyapatite, and the test group was given a combination of chitosan gel and hydroxyapatite crab shells. …”
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Effects of Meaningful Action Observation Therapy on Occupational Performance, Upper Limb Function, and Corticospinal Excitability Poststroke: A Double-Blind Randomized Control Tria... by Aryan Shamili, Afsoon Hassani Mehraban, Akram Azad, Gholam Reza Raissi, Mohsen Shati

“…Instead, patients in the control group watched nature videos as a placebo. Clinical outcomes were evaluated using the Canadian Occupational Performance Measure (COPM), Fugl-Meyer Assessment (FMA), Action Research Arm Test (ARAT), and Box-Block Test (BBT) on 3 occasions: baseline, post (at 4 weeks), and follow-up (at 8 weeks). …”
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Continuous Exercise but Not High Intensity Interval Training Improves Fat Distribution in Overweight Adults by Shelley E. Keating, Elizabeth A. Machan, Helen T. O'Connor, James A. Gerofi, Amanda Sainsbury, Ian D. Caterson, Nathan A. Johnson

“…The purpose of this study was to assess the effect of high intensity interval training (HIIT) versus continuous aerobic exercise training (CONT) or placebo (PLA) on body composition by randomized controlled design. …”
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The impacts of antipsychotic medications on eating-related outcomes: A mixed methods systematic review. by Rasha Alkholy, Karina Lovell, Penny Bee, Rebecca Pedley, Helen Louise Brooks, Richard J Drake, Prathiba Chitsabesan, Anam Bhutta, Abigail Brown, Rebecca L Jenkins, Andrew Grundy

“…Given the lack of direct evidence from high-quality placebo-controlled trials, it is pertinent to interpret the quantitative findings with caution. …”
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Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study by Martin Schecklmann, Anette Giani, Sara Tupak, Berthold Langguth, Vincent Raab, Thomas Polak, Csanád Várallyay, Wilma Harnisch, Martin J. Herrmann, Andreas J. Fallgatter

“…Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. …”
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Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression Surgery: A Randomized Controlled Study by Cattleya Thongrong, Patitha Chullabodhi, Pornthep Kasemsiri, Amnat Kitkhuandee, Narin Plailaharn, Lumyai Sabangban, Thirada Jimarsa

“…D) received intraoperative dexamethasone 4 mg iv and ondansetron 4 mg iv, whereas the control group (Gr. N) received placebo (0.9% normal saline 1 ml iv and 0.9% normal saline 2 ml iv). …”
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Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study by Jin Lee, Su Bum Park, Hyung Wook Kim, Hong Sub Lee, Sam Ryong Jee, Jong Hun Lee, Tae Oh Kim

“…As this is an observational study and has no placebo-controlled arm, further prospective randomized controlled trials are needed to confirm these results.…”
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Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch) by Dina Labib, Mark Haykowsky, Emer Sonnex, John R. Mackey, Richard B. Thompson, D. Ian Paterson, Edith Pituskin

“…Results We found that, contrary to the hypothesis, participants maintained LV EF over the follow-up period. Specifically, the placebo group exhibited a recovery in LV EF to levels comparable with the treatment groups, suggesting no long-term differential impact on cardiac function. …”
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Relationships of dermatologic symptoms and quality of life in patients with psoriatic arthritis: analysis of two tofacitinib phase III studies by Peter C. Taylor, Andrew G. Bushmakin, Joseph C. Cappelleri, Pamela Young, Rebecca Germino, Joseph F. Merola, Gil Yosipovitch

“…Objectives Evaluate relationships between changes in dermatologic assessments and quality of life (QoL) measures; quantify dermatologic symptom severity impacts on QoL in patients with psoriatic arthritis (PsA) treated with tofacitinib.Methods Data were from two phase III studies; patients received tofacitinib 5 or 10 mg twice daily (BID), adalimumab 40 mg every other week, or placebo advancing to tofacitinib 5 or 10 mg BID at Month 3. …”
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The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia by Mustafa Aydin, Ishak Ozel Tekin, Sait Mesut Dogan, Nesligul Yildirim, Mehmet Arasli, Muhammet Rasit Sayin, Ziyaettin Aktop

“…This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-𝛼 and IL-6 levels.…”
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