Effectiveness of the Homeopathic Preparation Neurexan® Compared with that of Commonly used Valerian-Based Preparations for the Treatment of Nervousness/Restlessness – an Observatio... by Rainer Hubner, Robbert van Haselen, Peter Klein

“…Each practice could include up to 15 subjects treated with either the homeopathic preparation Neurexan® or with combination formulations based on valerian extracts. There was no placebo group. Choice and doses of study therapies were at the respective physician's discretion. …”
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The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials by Shujie Li, Shengying Shi, Feng Chen, Jingming Lin

“…No serious adverse events or death events were reported, and there were no significant differences in the overall adverse events between baclofen and placebo. All reported side effects of baclofen were of mild-to-moderate intensity, and the drug was well tolerated. …”
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Effect of Vaginal Cream with the Combination of Honey, Olive, and Propolis on the Symptoms of Uterine Cervicitis Symptoms in Women: A Double-Blind Randomized Controlled Clinical Tr... by Hamideh Parsapour, Arezoo Shayan, Mehrnoosh Hosseinpoor, Seyedeh Zahra Masoumi, Farideh Kazemi, Shirin Moradkhani, Seyed Mohammad Hossein Oliaei, Zeinab Assareh, Mohammad Kazem Rashidi

“…The control group received a placebo cream and the same drugs as the intervention group. …”
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Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life by Zahra Hadian, Ali Akbar Moghadamnia, Sohrab Kazemi, Atena Shirzad

“…The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. …”
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Effect of Aloe Vera mouthwash on moderate gingivitis: Clinical and microbiological study by Lana Slewa Ishaq, Amal Hanna Aziz

“…The subjects in the first group (A) used 0.12% CHX mouthwash, the second group (B) used 80% AV mouthwash and the third group (C) used 0.9% normal saline as placebo for 14 days. Clinical examinations to assess PI, GI and BI were done at days 0, 14 and 21 post treatment. …”
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Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials by Stefano Marini, Domenico De Berardis, Federica Vellante, Rita Santacroce, Laura Orsolini, Alessandro Valchera, Gabriella Girinelli, Alessandro Carano, Michele Fornaro, Francesco Gambi, Giovanni Martinotti, Massimo Di Giannantonio

“…PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. …”
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Tratamento com imunobiológicos na rinossinusite crônica by Marcelo José da Silva de Magalhães, Itallo de Carvalho Soares, Pedro Henrique Sá Teixeira

“…Conclusão: o tratamento com os imunobiológicos avaliados nesta revisão sistemática mostrou superioridade clínica, laboratorial e endoscópica em relação ao placebo. Além disso, mostraram boa segurança, tolerabilidade e poucos efeitos adversos. …”
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Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experie... by Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner

“…This randomized, double-blind, double-dummy, placebo-controlled, four-way crossover study assessed the PK of morphine and its active metabolite, M6G, from crushed intranasal Morphine ARER and intact oral Morphine ARER compared with crushed intranasal ER morphine following administration to nondependent, recreational opioid users. …”
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Clinical Utility of Zuranolone for Postpartum Depression: A Narrative Review by Giannopoulos A, Singh J, Deligiannidis KM

“…In double-blind, randomized, placebo-controlled, clinical trials, zuranolone demonstrated rapid, statistically significant and clinically meaningful improvements in depressive symptoms. …”
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Short-acting growth hormone supplementation for bone age and growth rate in children with idiopathic short stature: a meta-analysis by Lianlian Yang, Fan Yang

“…The study will be strictly screened to ensure that all enrolled research subjects are patients with idiopathic short stature, and the intervention method is defined as short-acting GH replacement therapy, and a reasonable control group is set, such as placebo treatment, to ensure the scientificity and comparability of research results. …”
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Warfarin Use Is Associated with Increased Mortality at One Year in Patients with Idiopathic Pulmonary Fibrosis by Syeda Fatima Naqvi, Amir Humza Sohail, Dhairya A. Lakhani, James Maurer, Sarah Sofka, Yousaf B. Hadi

“…Previous data suggest that warfarin may worsen outcomes in IPF in patients with no indication for anticoagulation when compared to placebo. However, warfarin continues to be widely used for cardiac and thromboembolic indications in this patient population due to unavailability of data comparing warfarin with other anticoagulants in patients with IPF. …”
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Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect. by Sarah Batson, Alex Sutton, Keith Abrams

“…<h4>Results</h4>None of the covariates explored impacted relative treatment effects relative to placebo. Notably, the exploration of 'study follow-up' as a covariate supported the assumption that difference in trial durations is unimportant in this indication despite the variation across trials in the network.…”
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A novel (targeted) kinesio taping application on chronic low back pain: Randomized clinical trial. by María Lourdes Peñalver-Barrios, Juan Francisco Lisón, Javier Ballester-Salvador, Julia Schmitt, Aida Ezzedinne-Angulo, María Dolores Arguisuelas, Julio Doménech

“…The control group (17 female/14 male; 48.87 ± 9.09 years) underwent a placebo taping application. At post-treatment time there was a statistically significant reduction both in disability (Roland-Morris Disability Questionnaire) and pain (Numeric Pain Rating Scale) in the experimental group (disability: -2.88, 95% confidence interval [CI] -4.56 to -1.21, P < .001; pain: -1.58, 95% CI -2.67 to -0.54 P = .001) and the control group (disability: -1.82, 95% CI -3.46 to -0.17 P = .025; pain: -1.30, 95% CI -2.32 to -0.28 P = .008). …”
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Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews. by Annhild Mosdøl, Gunn Elisabeth Vist, Camilla Svendsen, Hubert Dirven, Inger Therese Laugsand Lillegaard, Gro Haarklou Mathisen, Trine Husøy

“…Evidence was often presented for intense sweeteners as a group or unspecified, and against several comparators (e.g. sugar, water, placebo, intake levels) with limited discussion on the interpretation of different combinations. …”
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Effects of intrathecal administration of sodium nitroprusside and nicardipine on cerebral pial microcirculation, cortical tissue oxygenation, and electrocortical activity in the ea... by Hyoung Youn Lee, Najmiddin Mamadjonov, Kyung Woon Jeung, Yong Hun Jung, Wan Young Heo, Yong Soo Cho, Byung Kook Lee, Tag Heo

“…At 30 min after resuscitation from cardiac arrest, 30 pigs randomly received 4 mg of SNP, 4 mg of nicardipine, or saline placebo via subdural intracranial catheters and were observed for 5 h. …”
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The effect of allergic rhinitis treatment on asthma control: a systematic review by Ellen Tameeris, Arthur M. Bohnen, Patrick J. E. Bindels, Gijs Elshout

“…Randomised controlled trials (RCTs) that reported objective (OAO) or subjective asthma outcomes (SAO) and compared the efficacy of anti-AR medication to placebo or conventional asthma medication were included. …”
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Laser Acupuncture Reduces Body Fat in Obese Female Undergraduate Students by Xiao-Guang Liu, Juan Zhang, Jian-Liang Lu, Timon Cheng-Yi Liu

“…The laser groups receiving 358 and 597 J/cm2 showed significant reductions in BW, BMI, BFM, waist girth, hip girth, and WHR after treatment compared with the placebo group. The percent reductions of BFM in the laser groups receiving 358 and 597 J/cm2 were 4.29% and 3.94%, respectively, and the corresponding values of BW were 1.99% and 1.63%, respectively. …”
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Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials by Ann Rann Wong, Angela Wei Hong Yang, Kangxiao Li, Harsharn Gill, Mingdi Li, George Binh Lenon

“…The treatment groups included CHM formulations, and the control included placebo, Western medication (WM), and lifestyle intervention (LI), with or without cointerventions (WM and/or LI). …”
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Effect of a multispecies probiotic on reducing the incidence of antibiotic-associated diarrhoea in children: a protocol for a randomised controlled trial by Hania Szajewska, Jan Łukasik

“…We aim to assess the effectiveness of a specific MP preparation (Winclove 612) in reducing the incidence of AAD in children.Methods and analysis A total of 350 children aged 6 months to 18 years, undergoing antibiotic treatment, will be randomly allocated to receive either a MP consisting of two strains of Bifidobacterium (B. bifidum W23 and B. lactis W51) and six strains of Lactobacillus (L. acidophilus W37, L. acidophilus W55, L. paracasei W20, L. plantarum W62, L. rhamnosus W71 and L. salivarius W24) at a total dose of 1010 colony-forming units daily, or a placebo, from the first day of antibiotic treatment until 7 days after antibiotic cessation, up to a maximum of 17 days. …”
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Telaprevir in treatment of chronic hepatitis C: safety issues by T. M. Ignatova

“…Tolerability of treatment with addition of telaprevir was satisfactory as a whole; however frequency of skin rashes and pruritus (over 50%), anemia (about 40%) and anorectal symptoms (26%) was higher, than at standard double therapy (placebo group). A little higher frequency of serious AE (7%), cancellation of all drugs due to AE (8%) was observed. …”
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