Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines by Klara Dégardin, Aurélie Guillemain, Yves Roggo

“…A second validation was performed using counterfeits, placebos, and generics. All the counterfeits were rejected, with p values close to zero. …”
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The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis: A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men by Peter Schwarz, Niklas Rye Jorgensen, Leif Mosekilde, Peter Vestergaard

“…Studies included were randomised, placebo-controlled trials of men. Results. Five BMD studies of antiresorptive treatment were included. …”
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Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis by Tingting Bao, Liuting Zeng, Kailin Yang, Yuehua Li, Fengying Ren, Yulong Zhang, Ziren Gao

“…In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. …”
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Safety of a Bioactive Polyphenol Dietary Supplement in Pediatric Subjects with Acute Diarrhoea by Shafiqul A. Sarker, Shamima Sultana, Mark Pietroni, Arthur Dover

“…Subjects were randomized to the study group (N=44) given a bioactive polyphenol dietary supplement in oral rehydration solution (ORS) or to the control group (N=41) given distilled water as a placebo in ORS twice daily for up to 4 days. All subjects received 10 mg zinc daily for the 4 days in the study. …”
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The effects of haloperidol on motor vigour and movement fusion during sequential reaching. by Sebastian Sporn, Joseph M Galea

“…Crucially, MTs could be reduced via: 1) enhanced speed of individual movements (motor vigour effect) and/or 2) enhanced speed of transition between movements (movement fusion effect). 95 participants were randomly assigned to a reward or no reward group and were given either 2.5mg of the dopamine antagonist haloperidol or a placebo (control group). An independent decision-making task performed prior to the main experiment suggested that haloperidol was active during the sequential reaching task (positive control). …”
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Induced Neurocysticercosis in Rhesus Monkeys (Macaca mulatta) Produces Clinical Signs and Lesions Similar to Natural Disease in Man by N. Chowdhury, A. Saleque, N. K. Sood, L. D. Singla

“…In this study, neurocysticercosis was induced in two rhesus monkeys each with 12,000 and 6,000 eggs, whereas three monkeys were given placebo. The monkeys given higher dose developed hyperexcitability, epileptic seizures, muscular tremors, digital cramps at 10 DPI, and finally paralysis of limbs, followed by death on 67 DPI, whereas the monkeys given lower dose showed delayed and milder clinical signs. …”
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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…The KEYNOTE-811 trial revealed an improved objective response rate (74% vs. 52%; P=.0001) and median duration of response (10.6 vs 9.5 months) with the addition of pembrolizumab (PD-1) to chemotherapy plus trastuzumab compared to that with the addition of placebo in patients with HER-2 overexpression-positive advanced adenocarcinoma. …”
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Oral administration of Limosilactobacillus reuteri VHProbi® M07 alleviates ovalbumin-induced allergic asthma in mice. by Guoqing Meng, Hongchang Cui, Congrui Feng, Chaoqun Guo, Lei Song, Zhi Duan

“…Serum levels of OVA-specific immunoglobulin (Ig) E and IgG1, inflammatory cells and cytokines in bronchoalveolar lavage fluid were assessed, along with histopathological examination of lung tissue. Compared to the placebo (PLA) group, mice treated with M07 exhibited significantly lower levels of OVA-specific IgE and IgG1 (P < 0.01). …”
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Effectiveness of Onion Extract Gel on Surgical Scars in Asians by Kumutnart Chanprapaph, Somsak Tanrattanakorn, Penpun Wattanakrai, Pranee Wongkitisophon, Vasanop Vachiramon

“…Each side was randomly assigned treatment with onion extract gel or placebo at 7 days after surgery. The product was applied three times daily for 12 weeks. …”
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Impact of Preventive Intravenous Amiodarone on Reperfusion Ventricular Fibrillation in Patients With Left Ventricular Hypertrophy Undergoing Open-Heart Surgery: Randomized Controll... by Chan-Juan Gong, Xiao-Kai Zhou, Zhen-Feng Zhang, Yin Fang

“…MethodsA total of 54 patients with LVH scheduled for open-heart surgery were enrolled and randomly divided (1:1) into 2 groups—group A (amiodarone group) and group P (placebo-controlled group). Thirty minutes before removal of the ACC, the trial drugs were administered intravenously. …”
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Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder by Manuel Arrojo-Romero, María Tajes Alonso, Jose de Leon

“…These two patients were characterized by lack of response to multiple treatments, making a placebo response to lamotrigine augmentation unlikely. …”
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Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats by Noor Atiqah Aizan Abdul Kadir, Asmah Rahmat, Hawa Z. E. Jaafar

“…Rats were fed on either normal chow or high fat diet for 10 weeks for obesity induction phase and subsequently received C. betacea extract at low dose (150 mg kg−1), medium dose (200 mg kg−1), or high dose (300 mg kg−1) or placebo via oral gavages for another 7 weeks for treatment phase. …”
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Cost-effectiveness Analysis of Radium-223 Dichloride in Metastatic Castration-Resistant Prostate Cancer Patients Without Previous Chemotherapy Treatment in Spain by Eva Tirado Mercier, Daniel Callejo Velasco, Marta Rubio Cabezas, Cristina Moretones Agut, Meritxell Granell Villalón

“…Main health resource use and efficacy inputs were obtained from a randomized controlled trial comparing radium-223 versus placebo. Unit costs were retrieved from Spanish databases and published sources. …”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Quantity and quality of sleep are measured in various ways, yet the consensus points towards Suvorexant's effectiveness in improving sleep time, onset, latency, and quality compared to placebo. In addition to helping improve isolated insomnia, Suvorexant helps improve sleep in patients that have other comorbidities such as obstructive sleep apnea, Alzheimer's disease, dementia, acute stroke, and delirium. …”
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Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins by Hu Wei, Jiang Wen-Bing

“…C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. …”
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Effect of Ozone Gel on Postoperative Sequelae after Surgical Removal of Impacted Lower Third Molars. by Sherwan Faisal Hamadamin, Ahmad Abdulla Haider

“…Methods: the current study enrolled 50 patients divided randomly in to two equal groups, Group I (study group) received ozone gel intra-socket and oral placebo postoperatively and Group II (control group) received a systemic antibiotic. …”
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An Assessment of Clinically Important Differences on the Worst Pain Severity Item of the Modified Brief Pain Inventory in Patients with Diabetic Peripheral Neuropathic Pain by James Marcus, Kathryn Lasch, Yin Wan, Mei Yang, Ching Hsu, Domenico Merante

“…In this post hoc analysis of a double-blind, placebo-controlled, phase 2 study, 452 randomized patients with diabetic peripheral neuropathic pain (DPNP) were followed over 5 weeks, with m-BPI data collected weekly and PGIC at treatment conclusion. …”
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TAS-102 Monotherapy and Combination Therapy with Bevacizumab for Metastatic Colorectal Cancer by Cheng-Jiang Liu, Ting Hu, Ping Shao, Wu-Yang Chu, Yu Cao, Feng Zhang

“…TAS-102 (OR=0.41, 95% CI: 0.18-0.93; OR=0.72, 95% CI: 0.63-0.83) and TAS-102 vs. placebo (OR=0.44, 95% CI: 0.29-0.67; OR=0.51, 95% CI: 0.42-0.62) were studied to actively prevent the occurrence of neutropenia, leukopenia, febrile neutropenia, anemia, and vomiting. …”
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Zuranolone for postpartum depression: a systematic review and meta-analysis of two randomized studies by Juliana Almeida Oliveira, Karine Eskandar, Marcos Aurélio Araújo Freitas, Chris Elizabeth Philip

“…We included randomized controlled trials comparing the effectiveness and safety of zuranolone versus placebo in women with postpartum depression. No time or language restrictions were applied. 297 results were retrieved, of which 11 papers were selected and fully reviewed by two authors. …”
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Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro by Jim Nicoll, Evgeniy A. Gorbunov, Sergey A. Tarasov, Oleg I. Epstein

“…Human mature adipocytes were incubated either with Subetta, with one of negative controls (placebo or vehicle), with one of nonspecific controls (release-active dilutions of antibodies to cannabinoid receptor type I or release-active dilutions of rabbit nonimmune serum), or with dimethyl sulfoxide (DMSO) at 37°C in a humidified incubator at 5% CO2 for three days. …”
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