GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes by María Isabel del Olmo-Garcia, Juan Francisco Merino-Torres

“…Only liraglutide and semaglutide have shown superiority in cardiovascular benefit compared with placebo. Although many of the mechanisms by which liraglutide and semaglutide produce a cardiovascular benefit are still unknown it would be desirable for these benefits to be incorporated into the therapeutic algorithms routinely used in clinical practice. …”
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5-ASA Suppositories in Hemorrhoidal Disease by P Gionchetti, M Campieri, A Belluzzi, C Brignola, M Miglioli, L Barbara

“…At the end of the study, 5-ASA suppositories showed results superior to those of placebo for all parameters evaluated (P<0.01). There were no adverse events reported related to the use of suppositories. 5-ASA suppositories are a valid therapeutic approach for hemorrhoidal disease as it reduces the intensity of all symptoms and significantly decreases congestion of the hemorrhoidal plexus.…”
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The Effect Of 0.01% Atropine On Myopia Progression by Amber Khalid

“…Results: Our study analyzed and compared the results of the interventional group, where atropine eye drops (0.01%) were administered daily at bedtime, with the control group, which received Tear Natural II eye drops as a placebo. Patients were followed for three years, with two years dedicated to observing treatment responses and a one-year washout period for the drug. …”
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Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“…Adverse events were rare and comparable to placebo. Vitamin D deficiency correlated with elevated TSH, anti-TPO, and anti-TG levels, with HT patients showing significantly lower vitamin D levels than healthy controls or hypothyroid patients. …”
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Dexmedetomidine Attenuates Inflammation in Elderly Patients Following Major Hepatobiliary and Pancreatic Surgery: A Randomized Clinical Trial [Corrigendum] by Chen X, Chen Q, Qin Z, Alam A, Zhao H, West R, Liu X, Li J, Li X, Yi B, Ma D, Gu J

“…Notes: The distribution of (A) Crea, (B) BUN, (C) NGAL showing renal function, and (D) Horowitz Index and (E) cLac reflecting pulmonary complications, as well as other biomarkers of (F) CA, (G) Cor, and (H) Ach in the placebo group (blue points) and the Dex group (yellow points) of all individuals are shown with violin plots (n=43 patients per group). …”
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Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease by Nicole K. Scripsema, Dan-Ning Hu, Richard B. Rosen

“…Observational studies have reported that increased dietary intake and higher serum levels of lutein and zeaxanthin are associated with lower risk of age-related macular degeneration (AMD), especially late AMD. Randomized, placebo-controlled clinical trials have demonstrated that xanthophyll supplementation increases macular pigment levels, improves visual function, and decreases the risk of progression to late AMD, especially neovascular AMD. …”
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A toolkit for quantifying individual response to herbal extracts in metabolic and inflammatory stress by Soo-yeon Park, Oran Kwon, Tim van den Broek, Jildau Bouwman, Ji Yeon Kim

“…Two randomized, double-blind, placebo-controlled crossover trials were conducted involving participants with PhenFlex challenge after overnight fasting. …”
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Clinical and Microbiological Efficacy of Adjunctive Systemic Quinolones to Mechanical Therapy in Periodontitis: A Systematic Review of the Literature by Carlos-M. Ardila, Jader-Alexander Bedoya-García

“…These RCTs found superior clinical and microbiological efficacy of adjunctive systemic moxifloxacin (MOX) and levofloxacin (LV) compared to subgingival debridement plus placebo. Improvements in PD and CAL were 2.4 ± 0.8 mm and 2.7 ± 0.9 mm for LV, and 1.5 ± 0.5 mm and 1.8 ± 0.5 mm for MOX, respectively. …”
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Comparative Evaluation of Efficacy of Herbal and Chlorhexidine Mouthwash on Gingival Health by Vaishnavi Senkalvarayan, Priya Kesavan, Jayachandran Dorairaj, R Madhumala, Saranyan Ravi, Ann Theresa Tomy

“…Results: It was found that both CHX and herbal mouthwash proved to be more effective than placebo in maintaining gingival health. There was no significant difference between the test group on gingival health. …”
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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Preclinical and open-label studies have suggested that grafted fetal neural tissue or viral vector gene transfer can achieve considerable biochemical and clinical improvements, whereas subsequent double-blind, placebo-controlled protocols have produced rather more modest and variable results. …”
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Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature by Chaima Hammami, Wafa Nasri

“…Collectively, different protocols have been proposed and almost all of them yield superior clinical and microbiological results compared to the placebo group. Conclusion. The overall findings of this review show a positive effect of the use of antibiotics as an adjunctive to NSPT, regardless of the antimicrobial agents used in our included studies. …”
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Impact of Pentoxifylline and Vitamin E on Ribavirin-Induced Haemolytic Anaemia in Chronic Hepatitis C Patients: An Egyptian Survey by M. Assem, M. Yousri

“…Selected 200 naïve chronic HCV patients, were randomized to receive either the standard antiviral therapy (peginterferon α-2b and RBV) plus pentoxifylline (800 mg) and high-dose vitamin E (1000 iu) daily (combined group) or received standard antiviral therapy plus placebo only (control group). They were followed up during treatment course and for 6 months posttreatment to assess the occurrence of anaemia and virological response, respectively. …”
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Pirfenidone: An Encouraging Therapeutic Approach For Enhancing Lateral Spinothalamic Tract Function After Spinal Cord Compression Injury by Noman Ullah Wazir, Ambereen Humayun, Irum Javaid, Asma Amir, Nayyab Khattak, Ayesha Iftikhar

“…The study involved three groups: Group A received a daily placebo, Group B received a daily dose of 200 mg/kg pirfenidone, and Group C received a daily dose of 500 mg/kg pirfenidone. …”
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Lack of Noradrenergic Modulation of Indirect Semantic Priming by Jacquelyne S. Cios, Regan F. Miller, Ashleigh Hillier, Madalina E. Tivarus, David Q. Beversdorf

“…Subjects attended three sessions: one each after propranolol (40 mg) (noradrenergic antagonist), ephedrine (25 mg) (noradrenergic agonist), and placebo. During each session, closely related, distantly related, and unrelated pairs were presented. …”
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The Effect of Taraxacum officinale Hydroalcoholic Extract on Blood Cells in Mice by Mehrdad Modaresi, Narges Resalatpour

“…Normal saline was administered as placebo for group, and dandelion hydro alcoholic extract in doses of 50,100, and 200 mg/kg was injected intraperitoneally for 20 days to test groups and the last group was control group.WBC, RBC, HB, HCT, platelet, and other cells were measured with automated cell counter. …”
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Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital-Acquired Bacterial Pneumonia and Ventilator-... by Wissam K. Kabbara, Elina Sadek, Hanine Mansour

“…A phase II trial showed similar tolerability and pharmacokinetics parameters of sulbactam–durlobactam in patients with urinary tract infections to placebo. However, no ABC infections were included in the trial. …”
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Elevated Blood Pressure in the Acute Phase of Stroke and the Role of Angiotensin Receptor Blockers by Simona Lattanzi, Mauro Silvestrini, Leandro Provinciali

“…Significant difference in BP values between treatment and placebo was found in two studies. No effect of the treatment was seen on dependency, death and vascular events at one, three or six months; the cumulative mortality and the number of vascular events at 12 months differed significantly in favour of treatment in one small trial which stopped prematurely. …”
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The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids by Hui Tang, Jing Lu, Yazhuo Duan, Dejun Li

“…Mirogabalin alleviated pain markedly in comparison with placebo. Administration of mirogabalin on a long-term basis is a flexible dosage regimen for patients with PHN. …”
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UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage Form by M. Ganesh, C. V. Narasimharao, A. Saravana Kumar, K. Kamalakannan, M. Vinoba, H. S. Mahajan, T. Sivakumar

“…Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. …”
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Dexmedetomidine Reduces Incidences of Ventricular Arrhythmias in Adult Patients: A Meta-Analysis by Qiaonan Zhong, Ashish Kumar, Abhishek Deshmukh, Courtney Bennett

“…Randomized controlled trials were included, examining the incidence of ventricular arrhythmias, ventricular tachycardia, or ventricular fibrillation with dexmedetomidine compared to placebo or an alternative sedative agent. For each publication that met the selection criteria, the patient demographics, incidence of arrhythmias, mortality, and adverse events were collected. …”
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