The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. by Alexander M Cole, Dorothy L Patton, Lisa C Rohan, Amy L Cole, Yvonne Cosgrove-Sweeney, Nicole A Rogers, Deena Ratner, Alexandra B Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I Lehrer, Alan J Waring, Phalguni Gupta

“…One day following the last film application, cervical biopsies from RC-101-exposed and placebo-controlled macaques were collected and were subjected to challenge with RT-SHIV in an ex vivo organ culture model. …”
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Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders by Fernando Kurita Varoli, Murillo Sucena Pita, Sandra Sato, João Paulo Mardegan Issa, Cássio do Nascimento, Vinícius Pedrazzi

“…NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. …”
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Effects of carob rich-polyphenols on oxidative stress markers and physical performance in taekwondo athletes by Nawel Gaamouri, Hassane Zouhal, Katsuhiko Suzuki, Mehrez Hammami, Aloui Ghaith, El Hafedh El Mouhab, Anthony C. Hackney, Ismail Laher, Omar Ben Ounis

“…We utilized a double-blind randomized placebo-controlled design to study the putative antioxidant role of six weeks of daily polyphenol supplementation on selected blood markers of oxidative stress and performance in taekwondo athletes. …”
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Clinical Effect of Teucrium polium Extract Ointment on Post Pilonidal Sinus Excision Wound Healing: A Randomized Controlled Trial by Reza Hosseinpour, Nuruddin Hosseini, Seyedeh Fatemeh Hekmatzadeh, Saadat Mehrabi, Hossein Sadeghi Mansourkhani, Marita Mohamadshahi

“…A total of 132 participants admitted to public hospitals in Yasuj with pilonidal sinus disease were randomized into three groups: T. polium ointment, serum, and placebo. The primary outcomes were changes in wound size and wound recovery time after surgery, while secondary outcomes included changes in wound edema and wound exudate. …”
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Effect of phenylbutazone administration on the enteroinsular axis in horses with insulin dysregulation by Kate L. Kemp, Jazmine E. Skinner, François‐René Bertin

“…In horses with ID, phenylbutazone treatment significantly decreased GIP Cmax compared with placebo (168.1 ± 59.26 pg/mL vs 242.8 ± 121.8 pg/mL; P = .04), but no significant effect of phenylbutazone was detected on aGLP‐1 and GLP‐2 concentrations. …”
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Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Rec... by Beatrice Setnik, Veeraindar Goli, Naama Levy-Cooperman, Catherine Mills, Megan Shram, Ira Smith

“…OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.…”
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Management of Fistulas in Patients with Crohn'S Disease: Antibiotic to Antibody by Pierre Paré

“…Antibiotics, cyclosporine, methotrexate and thalidomide have been used in uncontrolled trials; only azathioprine, 6-mercaptopurine and infliximab have been assessed in double-blind, placebo controlled studies. Relapse of the fistula occurs with all drugs, unless treatment is continued long term. …”
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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Participants randomised to PCV13 and placebo will also be randomised to one of two clinically relevant SPN3 strains from distinct lineages within clonal complex 180, clades Ia and II, creating five study groups. …”
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Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

“…The placebo patch was identical in appearance to ensure blinding. …”
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Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial by Sue F Plummer, Iveta Garaiova, Elizabeth A Williams, Bernard M Corfe, Simon Tazzyman, Nicholas Richards, Andrew R Trueman, Amy L Evans, Vicky A Grant

“…We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.Methods This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. …”
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Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents by Lian Tock, Ana R. Dâmaso, Aline de Piano, June Carnier, Priscila L. Sanches, Henrique Manoel Lederman, Regina M. Y. Ernandes, Marco Túlio de Mello, Sérgio Tufik

“…Metformin was more effective than the placebo in improving clinical parameters associated with obesity and steatosis.…”
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Efficacy of acupuncture for primary osteoporosis: a systematic review and meta-analysis of randomized controlled trials by Tianyi Ma, Tiantian Zhang, Le Zhang, Haoming Zhao, Ke Liu, Jianjun Kuang, Liang Ou

“…This study aimed to determine the efficacy of acupuncture in treating POP compared to conventional medicine or placebo. Methods We searched for potentially relevant studies in PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, China Biology Medicine disc, Wanfang database and ClinicalTrials.gov up to December 20, 2024. …”
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Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach by Liliana Sachelarie, Ioana Scrobota, Ioana Romanul, Raluca Iurcov, Georgiana Ioana Potra Cicalau, Liana Todor

“…Group A received standard periodontal therapy (non-surgical periodontal therapy (NSPT)) with probiotic supplementation (<i>Lactobacillus reuteri</i>, 2 × 10⁹ CFU daily for 8 weeks), and Group B received standard treatment with a placebo. Microbiological changes were assessed via quantitative PCR, while inflammatory markers (IL-1β, TNF-α) were analyzed using ELISA. …”
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Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo by Lisiane Conte, Sabrina Somacal, Sabrina Marafiga Nichelle, Cristine Rampelotto, Silvino Sasso Robalo, Miguel Roehrs, Tatiana Emanuelli

“…The effect of daily supplementation (0.05 mg/kg of body weight (b.w.)) with bixin, norbixin, lycopene, or placebo for 7 days was evaluated in a randomized, controlled crossover study in 16 healthy volunteers (8 men and 8 women). …”
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Sodium‐glucose cotransporter‐2 inhibitors in heart failure: an updated meta‐analysis by Yang Cao, Pengxiao Li, Yi Li, Yaling Han

“…Methods and results PubMed, Web of Science, and Cochrane Library were searched to identify randomized controlled trials comparing SGLT2i vs. placebo in HF patients. A total of 10 studies with 23 852 HF patients were eventually included. …”
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The use of methylene blue in adult patients with septic shock: a systematic review and meta-analysis by Ka Ting Ng, Pei En Kwok, Wei En Lim, Wan Yi Teoh, Mohd Shahnaz Hasan, Mohd Fitry Zainal Abidin

“…Randomized Clinical Trials (RCT) comparing methylene blue and placebo in adults with septic shock were included. …”
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Incremental long-term benefit of drug therapies for chronic obstructive pulmonary disease in quality of life but not mortality: a network meta-analysis by Qiong Pan, Jiongzhou Sun, Shiyuan Gao, Zian Liu, Yiwen Huang, Yixin Lian

“…The 7 drug therapies were not significantly associated with a lower risk of death compared to placebo. Nevertheless, ICS/LABA/LAMA/dupilumab is the most likely to be effective in decreasing mortality. …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…Our team developed Xiongzhitongluo granules specifically for AIS and is conducting a randomized controlled trial (RCT) to validate their effectiveness.Methods and analysisThis multi-center, randomized, double-blind, placebo-controlled clinical trial includes 120 participants randomly allocated to the intervention or placebo group. …”
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Prophylactic Theophyline reduces birth asphyxia related renal injury in term neonates by Salma Aziz, Syeda Maimoona Qudrat, Tanzeela Rani, Qurat-ul-Ain Chughtai, Misbah Aziz, Rai Muhammad Asghar

“…After taking written informed consent, all neonates were randomized into either A (Theophylline group) or B (Placebo group). Theophylline group received single dose of intravenous aminophylline (5 mg/kg, 0.25 ml/kg) while 0.25 ml/kg of normal saline was administered to placebo group over five-minute period within the first hour of presentation. …”
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Aerobic Exercise Training Adaptations Are Increased by Postexercise Carbohydrate-Protein Supplementation by Lisa Ferguson-Stegall, Erin McCleave, Zhenping Ding, Phillip G. Doerner III, Yang Liu, Bei Wang, Marin Healy, Maximilian Kleinert, Benjamin Dessard, David G. Lassiter, Lynne Kammer, John L. Ivy

“…The present study compared the effects of a carbohydrate and protein supplement in the form of chocolate milk (CM), isocaloric carbohydrate (CHO), and placebo on training adaptations occurring over 4.5 weeks of aerobic exercise training. …”
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