Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats by Karoline Klumpp, Frauke Lange, Alexandra S. Muscher-Banse, Nadine Schnepel, Kathrin Hansen, Adrian L. Lifschitz, Laura Mate, Mirja R. Wilkens

“…Forty-eight female rats were divided into three treatment and corresponding placebo groups: (1) a single intraperitoneal injection of 1,25-(OH)2D3 or placebo 12 h before sacrifice; (2) daily supplementation with 25-OHD3 by oral gavage or placebo for 10 days; and (3) a single intramuscular injection of vitamin D3 10 days before sacrifice. …”
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Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis by Beibei Zeng, Doudou Jia, Shengen Li, Xuna Liu, Boxu Zhu, Yanqi Zhang, Yan Zhuang, Fei Dai

“…Double-blind randomized controlled trials comparing biologics with placebo in patients with EoE and non-EoE EGIDs were collected and further screened for inclusion and exclusion. …”
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Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors by Riber Fabián Donoso Noroña, Nairovys Gómez Martínez, Adisnay Rodríguez Plasencia

“…Randomized clinical trials comparing sodium-glucose cotransporter type 2 inhibitors with placebo or standard treatment in patients with heart failure were included. …”
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Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol by Genane Loheswaran, Mera S. Barr, Reza Zomorrodi, Tarek K. Rajji, Daniel M. Blumberger, Bernard Le Foll, Zafiris J. Daskalakis

“…Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. …”
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Biomedicine or Holistic Medicine for Treating Mentally Ill Patients? A Philosophical and Economical Analysis by Søren Ventegodt, Isack Kandel, Joav Merrick

“…Another problem is that the effect of holistic medicine must be documented in a way that respects this school's philosophical integrity, allowing for subjective assessment of patient benefit and using the patient as his/her own control, as placebo control cannot be used in placebo-only treatment. …”
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The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia by Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi

“…The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. …”
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The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial by M. Sadeghzadeh, A. Rabieefar, P. Khoshnevisasl, N. Mousavinasab, K. Eftekhari

“…Materials and Methods. In this placebo controlled trial, fifty-six children aged 4–12 years with constipation received randomly lactulose plus Protexin or lactulose plus placebo daily for four weeks. …”
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Clinical Pharmacokinetics of Atogepant in Healthy Japanese and White Adults by Ramesh R. Boinpally, Brian McNamee

“…Methods A total of 50 participants (40 Japanese and 10 white) were enrolled into five cohorts; Japanese cohorts were randomized in a 4:1 ratio to atogepant (10 mg, 30 mg, or 60 mg daily dosing and 60 mg twice daily) or placebo. The white participants were randomized to atogepant (60 mg twice daily) or placebo. …”
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Whey Protein Lycosome Formulation Improves Vascular Functions and Plasma Lipids with Reduction of Markers of Inflammation and Oxidative Stress in Prehypertension by Ivan M. Petyaev, Pavel Y. Dovgalevsky, Victor A. Klochkov, Natalya E. Chalyk, Nigel Kyle

“…Control groups received lycopene or WP as a singular formulation or placebo pills for the same period of time. Combined WPL formulation of whey protein and lycopene has caused multiple favorable changes in the cardiovascular function (including a tendency to the reduced systemic blood pressure), the plasma lipid profile, and the inflammatory status of patients with prehypertension, whereas singular formulations of the compounds and placebo did not have such an effect. …”
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Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…The IL-6/IL-10 ratio in the control group was significantly increased (p=0.036) on the 14th day after placebo administration. We also found that most of the subjects who received placebo had high levels of IL-6 and ferritin (p=0.043) on the seventh day after the intervention. …”
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Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…In particular, the increase in bile acid-related metabolites in the 2 mg BID group was significantly greater than that in the placebo group, and unsaturated fatty acid-related metabolites decreased in both the 2 mg BID group and the placebo group, but there was no significant difference between the two groups. …”
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Effect of an inhaled glucocorticoid on reactive oxygen species production by bronchoalveolar lavage cells from smoking COPD patients by Gert T. Verhoeven, Annemarie J.M. Wijkhuijs, Herbert Hooijkaas, Henk C. Hoogsteden, Wim Sluiter

“…Paired results were obtained from 6 FP- and 9 placebo-treated patients. No significant change of Vmax was found in both patient groups. …”
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Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes by Mitsushi Fukukita, Masashi Ido, Syunsuke Osawa, Mikio Sasoh, Motoyasu Furuta, Kunio Ito, Masahiko Sugimoto, Yukitaka Uji

“…Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. …”
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The complexity of caffeine's effects on regular coffee consumers by Mateja Lesar, Jakob Sajovic, Dušanka Novaković, Maša Primožič, Eva Vetrih, Martin Sajovic, Anja Žnidaršič, Peter Rogelj, Andreas Daffertshofer, Zoran Levnajić, Gorazd Drevenšek

“…To answer this question, we recruited twenty habitual coffee drinkers who received either caffeinated or decaffeinated coffee (placebo) in a double-blind, randomized fashion. The two substances were identical except for the presence of caffeine. …”
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The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial by Kasra Saeedian, Saeed Davaryar, Maryam Emadzadeh, Alireza Akhavan Rezayat

“…The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. …”
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Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis. by Yi Wang, Ping Lei

“…However, probiotics were found to significantly improve overall muscle strength compared with the placebo group. MD: 2.99, 95%CI: 2.14-3.85; Z = 6.86, P < 0.001. …”
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The efficacy of Topical Clascoterone versus systematic spironolactone for treatment of acne vulgaris: A systematic review and network meta-analysis. by Mohammad A Basendwh, Amer Abdulaziz Alharbi, Sarah Abdulla Bukhamsin, Rahaf Abdulrashid Abdulwahab, Sarah Abdullah Alaboud

“…The random-effect size showed that TC 1% BID was significantly associated with a 12-week treatment success compared to placebo (Odds ratio, OR = 2.44, 95% CI: 1.12 to 5.30). …”
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Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial by Lea Kyhälä, Panu Mentula, Leena Kylänpää, Eeva Moilanen, Pauli Puolakkainen, Ville Pettilä, Heikki Repo

“…The results of the intervention and placebo groups were comparable showing that recombinant APC treatment did not alter the course of systemic inflammation in severe acute pancreatitis. …”
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Tyrosine supplementation is ineffective in facilitating soccer players' physical and cognitive performance during high-intensity intermittent exercise in hot conditions. by Kate J Donnan, Emily L Williams, Nicholas Stanger

“…Eight trained male soccer players completed a 92-minute high-intensity intermittent cycling sprint protocol whilst responding to soccer-specific decision-making tasks at various time points in 32°C (50%rh), in two counterbalanced conditions; tyrosine (150mg.kg-1) and placebo. No differences were found for peak power output (p = .486; 715 ± 98W vs 724 ± 98W, respectively), decision-making (p = .627; 86.9 ± 10.7% vs 88.6 ± 7.0%, respectively), cognitive appraisal (p = .693, 0.90 ± 0.42 vs 0.88 ± 0.39, respectively) nor affective states (p = .918; 1.15 ± 1.55 vs 1.14 ± 1.70, respectively) between tyrosine and placebo conditions. …”
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Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children by Rana Tafrishi, Hamid Ahanchian, Seyed ali Jafari, Abolfazl Pahlevanloo, Hamidreza Kianifar, Mohammadali Kiani, Nasrin Moazzen, Tahereh sadeghi, Peter D. Sly

“…There was no significant difference in the evaluated scores for asthma control (c-ACT) in both probiotic and placebo groups. After the intervention, the difference between the 2 groups has become significant (p < 0.05). …”
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