Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty: a prospective, double-blind, pilot, randomised controlled trial by Chunyan Li, Jie Yang, He Liu, Wen Tan, Song Zhang, Hongxing Zhang, Yuan Han, Mingshu Tao, Rongguang Liu, Jiaxing Fang, Dexian Chen, Qi Wei, Xingyu Xiong, Wenxin Zhao, Junli Cao

“…Background Postoperative sleep disturbance (PSD) is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective, double-blind, pilot, randomised, sham-controlled trial, patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS (a-tDCS) or sham tDCS (s-tDCS). …”
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A Feasibility Study on Utilizing Remote Sensing Data to Monitor Grape Yield and Berry Composition for Selective Harvesting by Leeko Lee, Andrew Reynolds, Briann Dorin, Adam Shemrock

Subjects: “…remotely piloted aircraft system (RPAS)…”
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Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study by Elie Nemr, Elie El Helou, Georges Mjaess, Albert Semaan, Josselin Abi Chebel

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Correlation of nailfold capillaroscopic changes using handheld dermatoscope with varying grades and severity of diabetic retinopathy in patients with type 2 diabetes mellitus: A pilot observational cross-sectional analytical study by Rohit Raina, Neha Chhabra, Shruti Barnwal, Shivani Vasisht, Naveen Kumar Kansal, Ravi Kant

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Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Randomized Clinical Trial Pilot Study by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

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Efficacy of Nonpreserved Sodium Hyaluronate Artificial Tears in Dry Eye Disease Patients Treated with Prostaglandin Analogs for Primary Open-Angle Glaucoma: A Prospective, Nonrandomized, Open-Label Pilot Study by Giulia Coco, Danilo Iannetta, Igino Febbraro, Ester Elmo, Gianluca Manni

“…In this prospective, nonrandomized, open-label pilot study, we evaluated the efficacy of a 0.15% hyaluronic acid (HA) nonpreserved ophthalmic formulation in decreasing DED symptoms in patients with open-angle glaucoma treated with prostaglandin analogs. …”
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A pilot mixed methods randomized control trial investigating the feasibility and acceptability of a culturally tailored intervention focused on beliefs, mistrust and race-congruent peer support for Black adults with diabetes by Meng-Jung Wen, Martha Maurer, Annika L. Pickard, Makenzie Hansen, Olayinka O. Shiyanbola

“…IntroductionBlack adults disproportionately experience poor glycemic control and medication nonadherence, yet few diabetes self-management programs address their unique health beliefs, provider mistrust and sociocultural barriers to taking diabetes medications. This 6-month pilot randomized feasibility trial compared a culturally tailored diabetes self-management program, incorporating beliefs about diabetes, mistrust, and race-congruent peer support to a standard diabetes program.MethodsAn embedded mixed methods design examined the feasibility of the pilot trial, including recruitment, retention, intervention adherence and participant acceptability. …”
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Combined real-time fMRI and real time fNIRS brain computer interface (BCI): Training of volitional wrist extension after stroke, a case series pilot study. by Avi K Matarasso, Jake D Rieke, Keith White, M Minhal Yusufali, Janis J Daly

“…<h4>Objective</h4>Pilot testing of real time functional magnetic resonance imaging (rt-fMRI) and real time functional near infrared spectroscopy (rt-fNIRS) as brain computer interface (BCI) neural feedback systems combined with motor learning for motor recovery in chronic severely impaired stroke survivors.…”
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Impact of a public health center nutrition education program on patients with type 2 diabetes in a primary care-based chronic disease management project: a pilot intervention study by Haerim Yang, Yoo Kyoung Park, Ji-hyun Lee, Hee-Sook Lim, Heejoon Baek, Hyejin Lee, Haeran Park, Pyunghwa Lee, Jooyoun Chung, Won Gyoung Kim

“…These patients were referred to public health centers for lifestyle management based on physician assessments at local clinics that were participating in a pilot project on primary health care-based chronic disease management. …”
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Use of virtual reality in port implantation to reduce perioperative anxiety and pain: protocol for a randomised controlled pilot trial at a single German university hospital (VIP-trial; DRKS00028508) by Christoph W Michalski, Felix J Hüttner, Colette Dörr-Harim, Sandra Graf, Hannah Feldmann, Lisa S Hunold, Kira C Steinkraus, Nadir Nasir

“…Previous studies suggested that VR hypnosedation may reduce the use of sedatives or general anaesthesia, and may offer additional benefits such as reducing postoperative pain and nausea, and promoting faster patient discharge.Methods and analysis The VIP trial is a randomised controlled pilot trial comparing the usage of VR during port implantation with the current standard of care (local anaesthesia and analgosedation if needed). …”
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Computed Tomography Analysis of Postsurgery Femoral Component Rotation Based on a Force Sensing Device Method versus Hypothetical Rotational Alignment Based on Anatomical Landmark Methods: A Pilot Study by Stefan W. Kreuzer, Amir Pourmoghaddam, Kevin J. Leffers, Clint W. Johnson, Marius Dettmer

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Investment climate assessment standards’ impact on the gross regional product growth of the Russian Federation subjects by L. I. Sergeyev, A. V. Samsonov

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Unmanned Aerial Vehicles for Real-Time Vegetation Monitoring in Antarctica: A Review by Kaelan Lockhart, Juan Sandino, Narmilan Amarasingam, Richard Hann, Barbara Bollard, Felipe Gonzalez

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Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to assess feasibility of a large multicentre trial by Jane Daniels, Lee Middleton, Tina Sara Verghese, Versha Cheed, Lisa Leighton, Pallavi Manish Latthe

“…Objective To evaluate the feasibility of a multicentre randomised controlled trial (RCT) comparing oestrogen treatment with no oestrogen supplementation in women undergoing pelvic organ prolapse (POP) surgery.Design and setting A randomised, parallel, open, external pilot trial involving six UK urogynaecology centres (July 2015–August 2016).Participants Postmenopausal women with POP opting for surgery, unless involving mesh or for recurrent POP in same compartment.Intervention Women were randomised (1:1) to preoperative and postoperative oestrogen or no treatment. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People Living With HIV Attending Centre of Excellence in HIV Care at a Tertiary Level Teaching Hospital in North India—A Pilot Study by Ragini Ram, Anuradha Subramanian MD, MSc, FRCP, Rajeshwari K. MD, PhD, FRCPCH

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Effects of home-based mirror therapy and cognitive therapeutic exercise on the improvement of the upper extremity functions in patients with severe hemiparesis after a stroke: a protocol for a pilot randomised clinical trial by Josefa Gonzalez-Santos, Raul Soto-Camara, Paula Rodriguez-Fernández, Maria Jimenez-Barrios, Jeronimo Gonzalez-Bernal, Carla Collazo-Riobo, Maha Jahouh, Yolanda Bravo-Anguiano, Jose M Trejo-Gabriel-Galan

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Does p‐lactate increase in patients with GSD1 after ingesting a meal with common‐size sources of fructose and galactose? Observations from a prospective, non‐blinded, crossover pilot study by Camilla Diana B. Caroee, Allan M. Lund

“…In this randomized cross‐over pilot study, 7 patients with GSD 1a (6) and GSD1b (1) orally consumed a common‐size fructose and galactose from either 200 mL of skimmed milk, 200 mL juice or 200 mL water. …”
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A Pilot Study of Hemoglobin A1C Levels in Patients with Type 2 Diabetes after Creation of a Patient Assistance Program Enrollment Committee at a Student-Run Free Clinic by John D. Salvemini, Gregory R. Vance, Amanda Pham, Garner Fincher, Johnny Yang, Harshin Sanjanwala, Leonna Conley, Alan Penman, James Pitcock

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mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized patients with methamphetamine use and opioid use disorder by Elenore P. Bhatraju, Devin N. Kennedy, Alexander J. Gojic, Matthew Iles-Shih, Joseph O. Merrill, Jeffrey H. Samet, Kevin A. Hallgren, Judith I. Tsui

“…Methods The study is a two-arm pilot randomized controlled trial (N = 40) comparing the mHealth Incentivized Adherence Plus Patient Navigation (MIAPP) intervention to treatment as usual. …”
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Outcomes of a pilot randomized clinical trial testing brief interventions to increase HIV pre-exposure prophylaxis uptake among rural people who inject drugs attending syringe services programs by Hilary L. Surratt, Sarah Brown, Abby L. Burton, Will Cranford, Laura C. Fanucchi, Christie Green, Stephanie M. Mersch, Rebecca Rains, Philip M. Westgate

“…We observed a 12.1% difference (14.6% vs 2.5%; ITT) and 12.8% difference (15.4% vs 2.6%; per protocol) in the primary outcome (PrEP initiation), in favor of the experimental intervention. Conclusion: This pilot trial established proof of concept for integrated PrEP care within SSPs in rural areas, and demonstrated a clinically meaningful difference in PrEP initiation between interventions, which warrants examination in a larger trial. …”
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