Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Study by Haiyan Zhou, Shuhua Li, Hongmei Yu, Shenggang Sun, Xinhua Wan, Xiaodong Zhu, Chun-Feng Liu, Ling Chen, Wei Xiang, Yaqing Sun, Haibo Chen, Shengdi Chen

“…SUSTAIN was an open-label, randomised, active-controlled parallel group exploratory pilot study (NCT03521635). A total of 98 patients were randomly allocated (1 : 1) to either pramipexole SR (n = 49) or pramipexole IR (n = 49) groups. …”
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Feasibility, safety and tolerability of estrogen and/or probiotics for improving vaginal health in Canadian African, Caribbean, and Black women: A pilot phase 1 clinical trial. by Biban Gill, Jocelyn M Wessels, Christina L Hayes, Jenna Ratcliffe, Junic Wokuri, Elizabeth Ball, Gregor Reid, Rupert Kaul, Jesleen Rana, Muna Alkhaifi, Wangari Tharao, Fiona Smaill, Charu Kaushic

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Evaluation of the Performance of an Ocular Surface Modulator Containing ST-Lysyal Versus Hyaluronic Acid Eyedrops in Patients with Dry Eye Disease: A Pilot Study by Stefano Barabino, Andrea Rosa, Sara Marini, Carlo Domenico Bianchi, Maurizio Rolando

“…Abstract Introduction Dry eye disease (DED) is a multifactorial condition of the ocular surface, primarily treated with tear substitutes, which do not fully restore natural tear functions. In this pilot study, we tested the hypothesis that T-Lysyal (T-Lys) improves symptoms and signs in patients with DED. …”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

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Authors' Reply: Commentary on “Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line” by Anthony R Pisani, Carlos Gallo, Madelyn S Gould, Nitya Kanuri, John E Marcotte, Brian Pascal, David Rousseau, Megan L Ranney, Bob Filbin, Shairi Turner

“… We appreciate Reierson’s thoughtful commentary on our 2019 paper, which described our experiences, ethical process, judgment calls, and lessons from a 2016-2017 data-sharing pilot between Crisis Text Line and academic researchers. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…Twelve anodal-left/cathodal-right 2 mA tDCS sessions over the dorsolateral prefrontal cortex will be performed in 6 weeks. Results. In the pilot phase, five patients received active tDCS and were double-blindly assessed, two presenting clinical response. …”
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Hidden costs of providing care: a pilot study of Japanese migrant care workers’ experiences in Aotearoa New Zealand during the COVID-19 pandemic by Shinya Uekusa

“…Employing the perspective of Critical Migration Studies (CMS), this pilot study explores the hidden costs of care provision, drawing insights from in-depth interviews conducted with 10 Japanese MCWs in late 2022 and early 2023, and presents mixed findings. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…The pilot EQA programme demonstrated potential scalability and provided data on the reliability of test results at the site. …”
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Virtual Reality High-Intensity Interval Training Exergaming Compared to Traditional High-Intensity Circuit Training Among Medical Students: Pilot Crossover Study by Pietro Merola, Marcos Barros Cardoso, Gabriel Barreto, Matheus Carvalho Chagas, Luana Farias Oliveira Saunders, Bryan Saunders, Danilo Cortozi Berton

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Virtual delivery of Go4Life® resources: A pilot study enhancing physical activity in older adults through pre- and post-intervention evaluation by Nazia Naz S. Khan, MD, MS, Syed S. Raza, BS, Nikhil Regmi, MD, Ling Wang, Ph.D

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Enhancing epigenetic aging clocks in cetaceans: accurate age estimations in small endangered delphinids, killer whales, pilot whales, belugas, humpbacks, and bowhead whales by Joseph A. Zoller, Ake T. Lu, Amin Haghani, Steve Horvath, Todd Robeck

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Ascertaining provider-level implicit bias in electronic health records with rules-based natural language processing: A pilot study in the case of prostate cancer by Ashwin Ramaswamy, Michael Hung, Joe Pelt, Parsa Iranmahboub, Lina P. Calderon, Ian S. Scherr, Gerald Wang, David Green, Neal Patel, Timothy D. McClure, Christopher Barbieri, Jim C. Hu, Charlotta Lindvall, Douglas S. Scherr

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D’un « regard-pilote » à l’écart. L’impact de Dubuffet sur les collectes de l’association L’Aracine by Déborah Couette

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Feasibility, safety and tolerability of estrogen and/or probiotics for improving vaginal health in Canadian African, Caribbean, and Black women: A pilot phase 1 clinical trial by Biban Gill, Jocelyn M. Wessels, Christina L. Hayes, Jenna Ratcliffe, Junic Wokuri, Elizabeth Ball, Gregor Reid, Rupert Kaul, Jesleen Rana, Muna Alkhaifi, Wangari Tharao, Fiona Smaill, Charu Kaushic

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Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

“…Pilot study outcomes include AF detection rate, anticoagulation uptake and other parameters to incorporate into sample size calculations for the main trial. …”
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The development and pilot testing of a behavioral activation-based treatment for depressed mood and multiple health behavior change in patients with recent acute coronary syndrome. by Emily C Gathright, Katherine Diaz Vickery, Woubeshet Ayenew, Matthew C Whited, Melissa Adkins-Hempel, Michelle Chrastek, Jill K Carter, Rochelle K Rosen, Wen-Chih Wu, Andrew M Busch

“…After the BA-HD manual was finalized, eight participants were enrolled in a single-arm pilot trial. The mean CSQ score was 30.57 ± 2.23, indicating high satisfaction. …”
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Qualitative and Quantitative Assessment of the Regenerate Bone Formed During Intramedullary Limb Lengthening Using a Goat (Caprine) Tibia Model: A Pilot Study by Anirejuoritse Bafor, Aidan Isler, Kell Sprangel, Sara McBride-Gagyi, Christopher A. Iobst

“…Using a goat tibia model, this pilot study is the first to evaluate the regenerate bone formed from intramedullary limb lengthening comprehensively. …”
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Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study by Hila Emmert, Franziska Rademacher, Matthias Hübenthal, Regine Gläser, Hanne Norsgaard, Stephan Weidinger, Jürgen Harder

“…Histologically, IL-13 alone and in combination with IL-4 increased epidermal spongiosis, a histological hallmark of AD skin. Taken together, our pilot study suggests that hair follicle–derived KCs from patients with AD represent a useful model system to study AD-related inflammation in a personalized in vitro model.…”
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Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

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Pilot-Scale Removal of Trace Steroid Hormones and Pharmaceuticals and Personal Care Products from Municipal Wastewater Using a Heterogeneous Fenton’s Catalytic Process by George Tangyie Chi, John Churchley, Katherine D. Huddersman

“…A continuous stir tank reactor incorporating a modified polyacrylonitrile (PAN) catalyst and dosed with hydrogen peroxide in a heterogeneous Fenton’s process was used at pilot scale to remove these compounds from wastewater that has undergone previous treatment via a conventional wastewater treatment system. …”
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