Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro by Reto Eggenschwiler, Komal Loya, Malte Sgodda, Francoise André, Tobias Cantz

“…In this study, we focused on three murine models for metabolic liver disorders: the copper storage disorder Wilson's disease (toxic-milk mice), tyrosinemia type 1 (fumarylacetoacetate-hydrolase deficiency, FAH−/− mice), and alpha1-antitrypsin deficiency (PiZ mice). Colonies of iPSCs emerged 2-3 weeks after transduction of fibroblasts, prepared from each mouse strain, and were maintained as individual iPSC lines. …”
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Receiver Jitter Tracking Characteristics in High-Speed Source Synchronous Links by Ahmed Ragab, Yang Liu, Kangmin Hu, Patrick Chiang, Samuel Palermo

“…Jitter tolerance analysis for a 10 Gb/s system shows that a near all-pass delay-locked loop (DLL) and phase-interpolator- (PI-) based de-skew performs best under low skew conditions, while, at high skew, architectures which leverage band-pass clock filtering or a phase-locked loop (PLL) for increased jitter filtering are more suitable. …”
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MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology by Cesar Seigi Fuziwara, Edna Teruko Kimura

“…Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. Recently, deregulation in microRNAs (miRNAs), a class of small endogenous RNAs that regulate protein expression, has been implicated in tumorigenesis and cancer progression. …”
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Point of Common Coupling Voltage Modulated Direct Power Control of Grid-Tied Photovoltaic Inverter for AC Microgrid Application by Shameem Ahmad, Hamza Mubarak, Umme Kulsum Jhuma, Tofael Ahmed, Saad Mekhilef, Hazlie Mokhlis

“…The proposed PCC voltage modulated (PVM) theory-based DPC method (PVMT-DPC) is composed of nonlinear PVM, nonlinear damping, conventional feedforward, and feedback PI controllers. For grid synchronization rather than employing phase-locked-loop (PLL) technology, in this study, direct power calculation of the PCC voltage and current is adopted. …”
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Hyperprogressive disease induced by PD-1 inhibitor monotherapy in lung adenocarcinoma with HER2 exon 20 insertion: report of two cases and review of literature by Guangjian Yang, Linyan Tian, Yan Wang

“…Here, we reported two heavily pretreated advanced lung adenocarcinoma cases with HER2 exon 20 insertion who presented HPD after two cycles of anti-PD-1 inhibitor sintilimab monotherapy, and they both carried co-alterations in the PI3K/AKT/mTOR and cell cycle signaling pathway. …”
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Super-Twisting Sliding Mode Control for Gearless PMSG-Based Wind Turbine by Mojtaba Nasiri, Saleh Mobayen, Quan Min Zhu

“…This controller is compared with Proportional-Integral (PI) and the first-order sliding mode (FOSM) controllers to illustrate the DC-link voltage regulation capability in the normal and grid fault conditions. …”
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Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model by Tianhang Luo, Jixin Shu, Zhengmao Lu, Ting Han, Guoen Fang, Xuchao Xue

“…Our results suggest that Cav-1 expression correlated with EPC functions during MODS and Cav-1 regulates the function of endothelial progenitor cells via PI3K/Akt/eNOS signaling during MODS. Thus, Cav-1 in EPCs could be an attractive target for the treatment of MODS.…”
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The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…EZH2 oversecretion was implicated in the malfunction of several fundamental signaling pathways like Wnt/β-catenin signaling, Ras and NF-κB signaling, PI3K/AKT signaling, β-adrenergic receptor signaling, and bone morphogenetic protein as well as NOTCH signaling pathways. …”
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Groundwater Quality and Suitability Assessment in Tirupur Region, Tamil Nadu, India by Kumar G., Saravanan Kothandaraman, Kathiresan Karuppanan, Sajjad Hussain

“…Irrigation water quality parameters such as SAR, EC, PI, Na %, RSBC, MR, and KR were used to understand the irrigation suitability. …”
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Theoretical and Experimental Study on Synchronization of the Two Homodromy Exciters in a Non-Resonant Vibrating System by Xue-Liang Zhang, Chun-Yu Zhao, Bang-Chun Wen

“…Synchronization of the two exciters stems from the coupling dynamic characteristic of the vibrating system having selecting motion, especially, under the condition that the parameters of system are complete symmetry, the torque of frequency capture stemming from the circular motion of the rigid frame drives the phase difference to approach PI and carry out the swing of the rigid frame; that from the swing of the rigid frame forces the phase difference to near zero and achieve the circular motion of the rigid frame. …”
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A Microcomputer-based GNSS Scintillation Monitor using Low-Cost Receiver by Orongan Manuel Allan, Deleña Miemarc John, Macalalad Ernest, Marloun Sejera, Hsiao Tung Yuan

“…The proposed design uses a U-blox EVK-6T’s GPS receiver, providing data updates at a rate of 1Hz, and a Raspberry Pi 4. The RPi calculates the S4c index with both a three-minute and a five-minute duration, then saves all the raw data and S4c values onto a locally stored CSV file. …”
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External Body Scores in Male Sakub Sheep Based on Different Physiological Age by Denis Agita Meliana, Agustinah Setyaningrum, Akhmad Sodiq, Agus Susanto

“…This study aims to determine the external body score, including body condition score (BCS), body fat percentage (BFP), plumpness index (PI), and body conformation index (BCI), of male Sakub sheep at different physiological ages (lambs vs rams). …”
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STUDI AKTIVITAS BIOLOGI SECARA IN SILICO SENYAWA NONIVAMIDE DAN NORDIHYDROCAPSAICIN SEBAGAI ANTI INFLAMASI by Theresia Nona Elfi, Yohanes Nong Bunga, Yohanes Bare

“…Ikatan Nordihydrocapsaicin dengan COX-2 membentuk ikatan pada residu asam amino TRP139 bersifat Pi-Alkyl dan ikatan hidrogen sebagai donor dengan Residu asam amino SER143 energi ikatan sebesar -248.47 cal/mol.…”
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Characterization of the Escherichia coli Antifungal Protein PPEBL21 by V. Yadav, R. Mandhan, M. Kumar, J. Gupta, G. L. Sharma

“…In-gel activity assay also showed that PPEBL21 was a propionaldehyde-specific ADH. The pI of PPEBL21 was observed to be 7.8. PPEBL21 was found to be stable up to a temperature of 40∘C with optimum activity at pH 7.5. …”
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Characterization of an allotriploid strawberry Fragaria × bifera Duchesne (Rosaceae) from Europe by Houshang Nosrati, Adam H. Price, Pedro Gerstberger, Chris C. Wilcock

“…From the mean intensity of fluorescence emitted by PI-stained nuclei for F. moschata, F. vesca, F. viridis and the hybrid, triploidy of the hybrid could be indicated. …”
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Automatic Voltage Regulator Betterment Based on a New Fuzzy FOPI+FOPD Tuned by TLBO by Mokhtar Shouran, Mohammed Alenezi

“…The unique control architecture, termed Fuzzy Fractional Order Proportional Integral (PI) plus Fractional Order Proportional Derivative (PD) plus Integral (Fuzzy FOPI+FOPD+I), integrates advanced control methodologies to achieve superior performance. …”
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转染自杀基因 pCEAcd-tk 的 SPC-A-1 细胞的死亡机制

“…取处理后的细胞, 提取 DNA, 琼脂糖凝胶电 泳; Hoechst 染色后荧光显微镜观察及碘化丙啶( PI)染色, 流式细胞仪分析细胞周期。【结果】① SPC-A-1 细胞株在转染了 pCEAcd-tk 体系后加前体药物存在明显的旁观者效应;② 处理细胞的基因组 DNA 琼脂糖凝胶电泳呈涂布状;③ 处理细胞用 荧光显微镜观察到形状变大, 无凋亡小体形成;④ 流式细胞仪分析到细胞周期发生改变。…”
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Control Characteristics Analysis of Multi-Section Morphing Wing Based on Centroid Self-Trimming by Hang Ma, Zhongbin Zhou, Dingshan Zhang

“…The computational analysis results show: 1) The asymmetry morphing of the sweep angle can significantly improve the maneuvering control performance of the UAV with a large lift coefficient. 2) The overall control efficiency of the UAV can be effectively improved by increasing the deflection rate of the sweep angle and the system parameters of the main controller and supervisory controller. 3) Increasing the feedback value of the integral term of the PI compensator in the inner loop can reduce the oscillation degree of the inner loop system in tracking the target signal when the Mach number is large, and improve the tracking accuracy of the inner loop system. 4) Increasing the wingspan ratio of the inner wing section can reduce the elevator deflection angle required to track the target pitch signal during the morphing process. …”
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Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review by Sapna Sadarangani, Melody L. Berg, William Mauck, Stacey Rizza

“…The patient’s ART was changed to a non-HIV protease inhibitor- (PI-) containing program, her symptoms improved, and she did not require hydrocortisone replacement. …”
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Antioxidant peptides encrypted in flaxseed proteome: An in silico assessment by Dawei Ji, Chibuike C. Udenigwe, Dominic Agyei

“…Most of the APs showed structural features that are important for antioxidation, including relatively low molecular weight (dipeptides and tripeptides only); amphipathic properties (hydrophobicity range of – 0.5 to + 0.5); relatively low Boman index (≤2); broad range of pI (3.7–10.8), and an abundance of antioxidant amino acid residues (e.g. glutamic acid and histidine). …”
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