Integrating feedback control for improved human-structure interaction analysis by Santiago A. Lopez, Daniel Gomez, Albert R. Ortiz, Sandra Villamizar

“…This study introduces three closed-loop control models to represent the human-structure interaction (HSI) effect: a Proportional Integral (PI) controller, the Pole Placement control algorithm (PP), and the Linear Quadratic Regulator with an Observer (LQR + L). …”
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Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line by Faeze Vali, Vahid Changizi, Majid Safa

“…To investigate the apoptotic effect of experimental groups PI-flow cytometry was used and expression of apoptotic proteins (caspase-7, caspase-9, PARP, and p53) was studied by western blot. …”
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Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation by Lingchen Yang, Hongwei Ma

“…Depending on results, Que. exhibited antitumor effects by stimulating autophagy via regulating the ATF5/JUN/PI3K/AKT/mTOR pathway in EC.…”
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Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Aci... by Olga Gordeeva, Sergey Khaydukov

“…Stimulation of the Activin/Nodal and BMP signaling cascades and inhibition of the MEK/ERK and PI3K/Act signaling pathways resulted in a significant decrease in the number of Oct4-expressing ES cells and a loss of tumorigenicity, similar to retinoic acid-stimulated EC cells. …”
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Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension by Amer Youssef, Victor K. M. Han

“…Low PO2 and IGFs maintained higher IR-A which was switched to IR-B in room air. PI3K/AKT was required for osteogenic differentiation, while MEK/ERK was required to repress an RUNX2 and OPN increase in low PO2. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. …”
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Model-Free Speed Control for Pumping Kite Generator Systems Based on Nonlinear Hyperbolic Tangent Tracking Differentiator by Mouaad Belguedri, Abdeldjabar Benrabah, Farid Khoucha, Emmanuel Delaleau, Mohamed Benbouzid, Khelifa Benmansour

“…Conventional use of proportional–integral (PI) controllers faces difficulties in meeting requirements for dynamic response, tracking performance, stability, and disturbance rejection encountered in this technology, notably the periodical variation in the rotational speed reference in maximum power point tracking in generation phases and the dynamic response for the step reference in transient ones. …”
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Oculodentodigital Dysplasia: A Case Report and Major Review of the Eye and Ocular Adnexa Features of 295 Reported Cases by Virang Kumar, Natario L. Couser, Arti Pandya

“…There were 73 different GJA1 mutations associated with these cases, of which the most common were the following missense mutations: c.605G>A (p.R202H) (11%), c.389T>C (p.I130T) (10%), and c.119C>T (p.A40V) (10%). Mutations most commonly affect the extracellular-1 and cytoplasmic-1 domains of connexin-43 (gene product of GJA1), predominately manifesting in microphthalmia and microcornea. …”
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PEGylated Cisplatin Nanoparticles for Treating Colorectal Cancer in a pH-Responsive Manner by Wei Li, Yongjun Sun, Jian Chen, Zhibin Jiang, Jinbao Yang

“…The HA-mPEG-Cis NPs exhibited antitumor efficacy via the PI3K/AKT/mTOR signaling pathway. The HA-mPEG-Cis NPs showed the lowest tumor volume and weight among all the groups in CT26 cell-bearing mouse model. …”
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Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature by Kurt J. Knowles, Eric X. Wei, Abhishek Seth, John Bienvenu, James Morris, Kenneth Manas, Paul Jordan, Moheb Boktor

“…In this case, testing revealed that the patient was also heterozygous for alpha-1-antitrypsin (A-1-AT) with the phenotype of PI⁎EM. This mutant phenotype has never been reported as a cause of A-1-AT disease and the abuse of SCs in a patient with this phenotype has also never been reported. …”
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Evaluation of the cytogenetic and genotoxic effects of an abamectin-based pesticide on Allium cepa roots by Ili Pinar, Sari Fikret

“…Mitotic index (MI) and phase index (PI) values were used for cytotoxicity assessment. …”
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PNMA1 is a novel immune modulator and therapeutic target in hepatocellular carcinoma linked to bile acid metabolism by Hongyu Chu, Yuezhan Shan, Chengwei Jiang, Yumin Zhong, Zijing Liu, Xuedong Fang, Zhaoying Yang

“…It promotes tumor progression via immune inhibition and PI3K–AKT pathway activation. Notably, PNMA1 has emerged as a promising therapeutic target for tyrosine kinase inhibitors, as confirmed by reduced IC50 values and molecular docking. …”
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An IoT-Based Hydroponic Monitoring and Control System for Sustainable Food Production by Omolola Ogbolumani, Bonginhlanhla Mabaso

“…Using IoT technologies, we enabled real-time data transmission from sensors to a dedicated web server - Amazon web services (AWS) and an Android mobile application powered by a Raspberry Pi3. This setup allows remote monitoring and control of the hydroponic system, reducing human intervention. …”
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Myogenic differentiation markers in muscle tissue after aerobic training by Rastegar Hoseini, Zahra Hoseini, Ayob Kamangar

“…The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. …”
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Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells by Sonia Martínez-Herrero, Ignacio M. Larráyoz, Laura Ochoa-Callejero, Josune García-Sanmartín, Alfredo Martínez

“…AM regulates the proliferation rate and the differentiation into neurons, astrocytes, and oligodendrocytes of stem/progenitor cells, probably through the PI3K/Akt pathway. The active peptides derived from the AM gene are able to regulate the cytoskeleton dynamics, which is extremely important for mature neural cell morphogenesis. …”
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Classification of Severity of Lung Parenchyma Using Saliency and Discrete Cosine Transform Energy in Computed Tomography of Patients With COVID-19 by Santiago Tello-Mijares, Francisco Flores, Fomuy Woo

“…A final fused (FF) image combining Q and DCT of PP and GGO-PI images was then obtained. Five convolutional neural networks (CNNs) and five classic classification techniques, trained using FF and grayscale PP images, were tested. …”
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Novel approaches in myelofibrosis by Steffen Koschmieder

“…These drugs target transcription, nuclear export, survival pathways, or various intracellular pathways, ranging from JAK‐STAT signaling to PI3‐Kinase, TP53, PIM1, or S100A8/A9/toll‐like receptor pathways. …”
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X射线致人骨髓间充质干细胞放射损伤细胞模型的建立 by 孔祥波, 尹萍, 任婕, 钟婉珍, 刘仰, 李洁, 房思炼

“…【方法】hBMMSC经X射线照射后，通过Westernblotting和RT-qPCR方法检测Beclin1、Sox2、Nanog、RUNX2和OGN的基因表达变化；应用Annexin-V/PI双标法检测凋亡率的变化；通过克隆形成实验检测增殖率的变化；采用微板法检测成骨诱导后碱性磷酸酶活性的变化。…”
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Plausible Last Interglacial Antarctic Ice Sheet Changes Do Not Fully Explain Antarctic Ice Core Water Isotope Records by Huiling Zou, Louise C. Sime, Nancy A. N. Bertler, Elizabeth D. Keller, Eric W. Wolff

“…Some LIG AIS configurations show higher skill than PI AIS configurations in simulating the inter‐core differences. …”
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