Exosomes Derived from Mesenchymal Stem Cells Ameliorate Hypoxia/Reoxygenation-Injured ECs via Transferring MicroRNA-126 by Qunwen Pan, Yan Wang, Qing Lan, Weiquan Wu, Zhenxuan Li, Xiaotang Ma, Liming Yu

“…Akt, p-Akt, p-eNOS, and cleaved caspase-3 expressions were examined by western blot. The PI3K inhibitor (LY294002) was used in pathway analysis. …”
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AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Additionally, this process activates the pSTAT3/PI3K-AKT signaling pathway. Organoid models and liposomal-chitosan nanocomplex drug delivery systems showed that reducing AGD1 expression enhanced the therapeutic effect of docetaxel in CRPC. …”
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Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1’s role in promoting vasculogenic mimicry in clear cell renal cell carcinoma by Chao Xu, Sujing Zhang, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Shengtao Dai, Bowei Zhang, Meng Zhu, Yuepeng Liu, Junfei Gu

“…Additionally, FOXM1 was found to be upregulated in ccRCC, correlating with clinical pathological features and positively regulating PYCR1, thereby activating the PI3K/AKT/mTOR signaling pathway and promoting VM formation. …”
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Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway by Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S

“…Meanwhile, remimazolam increased NRF2, HO-1, P-AKT, P-GSK-3β, and the nuclear accumulation of NRF2. The PI3K/AKT inhibitor LY294002 reversed the role of remimazolam in brain I/R injury.Conclusion: This study demonstrates that remimazolam activates the AKT/GSK-3β/NRF2 pathway, thereby attenuating oxidative stress and apoptosis to protect against brain I/R injury.Keywords: remimazolam, AKT/GSK-3β/NRF2 signaling pathway, ischemia-reperfusion injury, apoptosis, oxidative stress…”
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Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…The best models achieved high AUC scores, namely 0.7 for RTK-RAS, 0.8 for PI3K, 0.75 for TP53, and 0.4 for NOTCH, and therefore, demonstrated the potential of ML models in accurately predicting oncogenic signaling pathways from radiomic features, thereby informing personalized therapeutic approaches and improving patient outcomes. …”
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Addition of Vitamin C on Diet to Improve Immunity on Tiger Grouper, Epinephelus fuscoguttatus to Infection Viral Nervous Necrosis by F. Johnny, K. Mahardika, I.N.A. Giri, D. Roza

“…Perception of test fish immunities parameter done to phagocytic activity (PA), make of phagocytic index (PI) and lysozyme activity (LA). Attempt result indicated that addition of vitamin C in diet dose between 600-1,200 mg/kg after 60 treatment day yield highest survival rate, PA and LA compared to other treatments. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Keywords such as ''Oridonin,'' ''Apoptosis,'' ''Cancer Cell Signaling Pathways,'' ''PI3K/AKT,'' ''ROS,'' and ''Nanotechnology'' were used, yielding 96 relevant studies. …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…The oxidative stress induced by MAP17 activates the p53, PI3K-AKT, and Wnt pathways, all of which contribute to the progression of NASH.Keywords: NASH, MAP17, macrophage infiltration, immunotherapy response, oxidative stress…”
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Effect of different hormonal protocols with timed AI on clinical signs of estrus and conception rates in Bulgarian Murrah buffaloes by Radena Nenova

“…The results show that the factor protocol has the most pronounced effect on TAI success (p<0.01), significantly lowest being the pregnancy rate (pi val- ues) under the Presynch/Ovsynch protocol – only 23.9%, com- pared to 40.7 and 47.4% under Ovsynch and Ovsynch+PRID, respectively. …”
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24 个常用STR基因座的突变观察与分析

“…【目的】 观察24个常用STR基因座等位基因突变的现象及特点65377; 【方法】 对5 084例肯定亲权关系的案例进行分析,筛选等位基因突变事件,确定突变等位基因的来源,统计各STR基因座的突变率,分析突变的规律及其特点65377; 【结果】 在24个STR基因座中共观察到172个突变事件,STR基因座的突变率介于0 ~ 0.492%65377;每个突变案例的突变基因座数目为1 ~ 3个65377;突变模式符合逐步突变模式,最多突变步数为四步65377;父系突变与母系突变比例为3.55:165377; 【结论】 STR基因座等位基因突变现象较为常见65377;当出现STR基因座突变时,应结合突变的STR基因座信息计算PI值65377;…”
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Adaptive Trajectory Tracking Algorithm of a Quadrotor with Sliding Mode Control and Multilayer Neural Network by Kang Niu, Di Yang, Xi Chen, Rong Wang, Jianqiao Yu

“…Firstly, the paper establishes the quadrotor dynamic model and introduces the conception of Sigma-Pi neural network. Then, the paper adds the neural network to the attitude and trajectory tracking control loop. …”
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Analysis of Production Performance and Medicine Cost Expenditure Before and After Avian Infectious Bronchitis in Commercial Broiler Farms by Muhammad Viqih, Gunistiyo Gunistiyo, Hartanto Mulyo Raharjo

“…The results of this analysis revealed significant differences in the variables of performance index (PI), feed conversion ratio (FCR), and medicine costs within several clusters before and after being infected with avian infectious bronchitis. …”
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Control of a Three-Input DC-DC Converter Suitable for DC Motors by Amin Alizadeh Asl, Seyed Hossein Hosseini, Naser Vosoughi Kurdkandi, Ramin Alizadeh Asl

“…In the third step, the system is decoupled in the steady state by a simple matrix. The PI controller tracks the reference inputs of the controller. …”
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Design and Dynamic Modelling of a Hybrid Power System for a House in Nigeria by Lawrence O. Aghenta, M. Tariq Iqbal

“…The proposed PV system consists of PV arrays, DC–DC boost converter, MPPT controller, single-phase full-bridge inverter, inverter voltage mode controller (PI controller), and single-phase step-up transformer. …”
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The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways by Wanqiong Yuan, Chunli Song

“…In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. …”
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Real-time energy efficiency analysis of buildings using ir imaging and computer vision by Lupoiu Teodor, Carutasiu Mihail-Bogdan, Necula Horia

“…Additionally, an experimental stand comprising of a miniature model house made from different materials and insulation types, an IR camera and a Raspberry Pi were considered. It will provide data for an AI based model, which employs a robust and already proven architecture, YOLOv8 namely, used to determine the thermal characteristics of the analysed materials and the energy performances respectively.…”
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The Rank-One property for free Frobenius extensions by Bellamy, Gwyn, Thiel, Ulrich

“…Examples where the result is applicable include graded Hecke algebras, extended affine Hecke algebras, quantized enveloping algebras at roots of unity, non-commutative crepant resolutions of Gorenstein domains and 3 and 4 dimensional PI Sklyanin algebras.In particular, since the multiplicity matrix for restricted rational Cherednik algebras has the rank-one property if and only if its Cartan matrix does, our result provides a different proof of the original conjecture.…”
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Research Advances in Antitumor Mechanism of Evodiamine by Luning Li, Cunxin Zhang, Chen Huang, Xinchen Tian, Wenxue Sun, Shulong Jiang

“…Evodiamine can inhibit Wnt/β-catenin, mTOR, NF-κB, PI3K/AKT, JAK-STAT, and other signaling pathways in various cancer cells, and it can significantly downregulate the expression of many tumor markers, such as VEGF and COX-2. …”
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BDNF 基因修饰淋巴细胞培养上清对 PC12 细胞氧化应激损伤的保护作用

“…【方法】MTT法检测H2O2和多巴胺(dopamine,DA)对PC12细胞生长的抑制率,Hoechst染色和PI染色流式细胞仪(flowcytometry,FCM)检测H2O2和DA对PC12细胞凋亡的诱导作用。…”
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Glucosinolates, Carotenoids, and Vitamins E and K Variation from Selected Kale and Collard Cultivars by Moo Jung Kim, Yu-Chun Chiu, Kang-Mo Ku

“…For collard, total glucosinolate was the highest in “Top Bunch” while carotenoids were the highest in “Green Glaze.” An accession PI261597 was the highest in phylloquinone. In addition to the total content of each phytonutrient class, their composition differed among cultivars, indicating that each cultivar may have differential regulatory mechanisms for biosynthesis of these phytonutrients. …”
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