Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain by N. David Åberg, Katarina Gustafson Brywe, Jörgen Isgaard

“…It appears that the MAPK signaling pathway is required for IGF-Istimulated proliferation in vitro, whereas the PI3K/Akt or MAPK/Erk signaling pathway appears to mediate antiapoptotic effects. …”
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Assessing the Use of Crushed Rock Aggregate and Carbon Black for Laterite Soil Stabilization in Road Construction. by Turyamureeba, Emmanuel

“…Graphical analysis of the results revealed that a blend of 50% lateritic soil, 40% aggregates, and 10% carbon black was the most effective, yielding a CBR of 63.0 at 98% relative compaction and a Plasticity Index (PI) of 6.5. These results meet the General Specifications for Roads and Bridges by Uganda’s Ministry of Works, Housing, and Communication, which require a CBR above 60%. …”
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Comparing spirometry, impulse oscillometry with computed tomography for assessing small airway dysfunction in subjects with and without chronic obstructive pulmonary disease by Suyin Huang, Fan Wu, Zhishan Deng, Jieqi Peng, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Xiaohui Wu, Qi Wan, Gaoying Tang, Shengtang Chen, Changli Yang, Yongqing Huang, Shuqing Yu, Pixin Ran, Yumin Zhou

“…Only spirometry-defined SAD group had more lower lung function (FEV1/FVC: adjusted difference=-10.7%, 95% CI: -13.5% to -7.8%, p < 0.001) and increased airway wall thickness (Pi 10: adjusted difference = 0.3 mm, 95% CI: 0 to 0.6 mm, p = 0.046) than only CT-defined SAD group. …”
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CLOVES Syndrome: A Review of Clinical, Genetic, and Therapeutic Aspects by Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Agnieszka Kulczycka-Rowicka, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…It focuses on the role of PIK3CA gene mutations, challenges in diagnosis, and treatment options, including PI3K/AKT/mTOR pathway inhibitors. Research Materials and Methods: This article is based on a review of the current literature and clinical reports from various sources. …”
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Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathway. We also found that intranasal mometasone furoate therapy can promote nasal IL-37b expression. …”
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PICT: A low‐cost, modular, open‐source camera trap system to study plant–insect interactions by Vincent Droissart, Laura Azandi, Eric Rostand Onguene, Marie Savignac, Thomas B. Smith, Vincent Deblauwe

“…We developed PICT (plant–insect interactions camera trap), an inexpensive (<100 USD) do‐it‐yourself CT system based on a Raspberry Pi Zero computer designed to continuously film animal activity. …”
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Multitask Learning-Based Pipeline-Parallel Computation Offloading Architecture for Deep Face Analysis by Faris S. Alghareb, Balqees Talal Hasan

“…A computation offloading approach, on the other hand, is leveraged to distribute computation-intensive tasks to the server edge, whereas lightweight computations are offloaded to edge devices, i.e., Raspberry Pi 4. To train the proposed deep face analysis network architecture, two custom datasets (HDDB and FRAED) were created for head detection and face-age recognition. …”
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Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

“…Five years after her first evaluation, she developed mild memory impairment and underwent PET-FDG and PiB scans that showed left frontal hypometabolism and cortical amyloidosis. …”
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Oral cannabidiol did not impair learning and memory in healthy adults by Hanna H. Gebregzi, Joanna S. Zeiger, Jeffrey P. Smith, Libby Stuyt, Luann Cullen, Jim Carsella, Daniel C. Rogers, Jordan Lafebre, Jennah Knalfec, Alfredo Vargas, Moussa M. Diawara

“…However, a highly significant interaction effect between treatment groups (CBD vs. placebo) and age of subjects was observed for the PI ratio (P = 0.008; n = 35). Conclusions The results of this study suggest that administration of oral CBD alone does not significantly impair L&M in healthy adults. …”
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Autoregulatory Feedback Mechanism of P38MAPK/Caspase-8 in Photodynamic Therapy-Hydrophilic/Lipophilic Tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc-Induced Apoptosis of Human Hepa... by Yu Wang, Chunhui Xia, Wei Chen, Yuhang Chen, Yiyi Wang, Tao Li

“…In the present study, therefore, effect of TαPcZn-PDT on apoptosis, P38MAPK, p-P38MAPK, Caspase-8, Caspase-3, Bcl-2, Bid, Cytochrome c, and mitochondria membrane potential in Bel-7402 cells without or with P38MAPK inhibitor SB203580 or Caspase-8 inhibitor Ac-IEFD-CHO was investigated by haematoxylin and eosin (HE) staining assay, flow cytometry analysis of annexin V-FITC/propidium iodide (PI) double staining cells and 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide (JC-1), and immunoblot assay. …”
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An Integrated Stacking Ensemble Model for Natural Gas Purchase Prediction Incorporating Multiple Features by Junjie Wang, Lei Jiang, Le Zhang, Yaqi Liu, Qihong Yu, Yuheng Bu

“…The model was subsequently applied to predict natural gas purchase volumes in Pi County, Chengdu, China. In November 2024, a side-by-side comparison of the predicted and actual data revealed a maximum error of just 5.39%. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. These results suggested that the therapeutic efficacy of the combined treatment of Akk and CDDP was superior to the only CDDP treatment, which could enhance immune regulation and would be a promising strategy for the treatment of lung cancer.…”
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Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes by Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Beatriz Vazquez, Marta Hernández, Carmen Jurjo, Ramon Espinet, Juan Antonio Ezpeleta, Didac Mauricio

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Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular flui... by Chong Wang, Ying Feng, Yu Chen, Xianhua Lin, Xiangjuan Li

“…The OSM signaling pathway, the IL-10 anti-inflammatory signaling pathway, and the PI3K−Akt signaling pathway are three notable pathways involved in affecting ovarian reserve capacity according to bioinformatics analysis. …”
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G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth by Whitney K. Petrie, Megan K. Dennis, Chelin Hu, Donghai Dai, Jeffrey B. Arterburn, Harriet O. Smith, Helen J. Hathaway, Eric R. Prossnitz

“…Here, employing ERα-negative Hec50 endometrial cancer cells, we demonstrate that GPER mediates estrogen-stimulated activation of ERK and PI3K via matrix metalloproteinase activation and subsequent transactivation of the EGFR and that ER-targeted therapeutic agents (4-hydroxytamoxifen, ICI182,780/fulvestrant, and Raloxifene), the phytoestrogen genistein, and the “ERα-selective” agonist propylpyrazole triol also function as GPER agonists. …”
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Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress by Siyuan Luo, Junnan Li, Yuqing Zhou, Zihang Zhai, Qiang Li, Zhenglin Huang, Wencan He, Kejun Zhong, Bo Kong, Zanxian Xia, Hang Fai Kwok, Lipeng Zhu

“…C. elegans exposed to DIOP exhibit increased oxidative stress, evidenced by higher ROS levels and lipofuscin buildup. Importantly, the PI3K/AKT and MAPK pathways are implicated in the response to DIOP-induced toxicity. …”
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Metagenomics and Faecal Metabolomics Integrative Analysis towards the Impaired Glucose Regulation and Type 2 Diabetes in Uyghur-Related Omics by Rebiya Nuli, Jureti Azhati, Junxiu Cai, Aizhatiguli Kadeer, Bing Zhang, Patamu Mohemaiti

“…Alchornoic acid, PE (14 : 0/20 : 3), PI, L-tyrosine, LysoPC (15 : 0), protorifamycin I, pimelic acid, epothilone A, 7-dehydro-desmosterol, L-lysine, LysoPC (14 : 1), and teasterone are the most significant differential enriched metabolites. …”
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A Low Complexity Dual-Phase Alternating Scheme is Used With the PTS Method to Reduce PAPR for B5G Systems by Yung-Ping Tu, Chen-Wei Hsu

“…In the second stage, we use the dual-phase alternation of 0 and <inline-formula> <tex-math notation="LaTeX">$\pi $ </tex-math></inline-formula> radian to wimple the effect of the peaking power of each subcarrier on PAPR one by one until the estimated amount <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>. …”
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Posterior instrumented correction and fusion of Scheuermann´s results in physiological reconstruction of sagittal alignment and excellent overall clinical outcome- clinical trail o... by M.-L. Jensch, U. Platz, M. Quante, M. Köszegvary, B. Thomsen, J. Gliemroth, C. Berlin, H. Halm

“…Whole spine x-rays were analyzed (preop, postop, after 6, 12, 24 months): sagittal and coronary Cobb angles, and pelvic parameters were evaluated; ideal lumbar lordosis (LL) was calculated using formula of le Huec (LL = 0.54*PI + 27.6). Surgical time, complications and blood loss were compared. …”
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Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users by Dongmei Li, Zidian Xie, Sadiya Bi Shaikh, Irfan Rahman

“…KEGG pathway analysis indicated their involvement in cancer pathways, including small cell lung cancer, renal cell carcinoma, and signaling pathways (neurotrophin, ErbB, PI3K-Akt, FoxO, Hippo, MAPK, TGF-beta). Overexpression of hsa-miR-125b-5p promoted DNA damage in bronchial epithelial cells. …”
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