Establishing nomograms for predicting disease-free survival and overall survival in patients with breast cancer by Ling Zhou, Lifen Bai, Huiyin Zhu, Chongyong Guo, Sheng Liu, Lu Yin, Jian Sun

“…Stratified analysis was performed with the cut-off value of exp (pi) of 4.0-fold in DFS and OS, respectively.Results Multivariate Cox regression analysis indicated that ALDH, p-AKT and pathological stage III were independent risk factors for the recurrence among BC patients. …”
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The effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance: a systematic review and meta-analysis by Thomas P. J. Solomon, Matthew J. Laye

“…The effect of post-exercise heat exposure on performance in hot conditions (33–40 °C) was trivial (ratio of means = 1.04) with poor precision (95%CI 0.94–1.15, P = 0.46) and low predictive certainty (95%PI 0.81–1.33). There were also trivial effects on performance in thermoneutral conditions (18–24 °C) and speed at lactate threshold, small effects on V̇O2max, heart rate, core temperature, and sweat rate, and a moderate effect on thermal sensations. …”
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A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1 by Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen

“…The regulation on the GLP1 receptor and its downstream transcription factor PI3K/AKT/FOXO1 pathway, which causes increased pancreatic and duodenal homeobox 1 (Pdx1) and MafA mRNA expression but causes decreased MAFB expression, may be the mechanism involved in this process.…”
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Sex reversal induced by 17β-estradiol may be achieved by regulating the neuroendocrine system of the Pacific white shrimp Penaeus vannamei by Tao Wang, Shihao Li, Yang Yu, Fuhua Li

“…The observed retardation in growth in the EM group may be attributed to the potential for neuronal damage and disruptions in the cell cycle and PI3K-Akt signaling pathways. Furthermore, the success of E2-induced sex reversal may be associated with the downregulation of neuroactive ligand-receptor interaction, dopaminergic synapse, and insulin signaling pathways, as well as the activation of steroidogenesis. …”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…When tested in vivo in GRPR expressing PC-3 xenografts, both radioantagonists demonstrated high tumor accumulation (6.3 ± 0.5%IA/g and 5 ± 1%IA/g at 1 h pi, respectively), with good retention over time (4 ± 2%IA/g and 3.1 ± 0.1%IA/g at 4 h pi, respectively). …”
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Sistem Identifikasi Kesehatan Pencernaan Berdasar Suara Usus Menggunakan Embedded System by Ryzaldi Ananda Fabiana, Barlian Henryranu Prasetio, Eko Setiawan, Syahrul Chilmi, Edita Rosana Widasari

“…Penelitian ini menggunakan stetoskop yang dimodifikasi dengan soundcard yang terhubung dengan raspberry pi dan ditampilkan melalui aplikasi VNC Viewer. …”
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感染后肠易激综合征小鼠IL-17、occludin和ZO-1的动态改变 by 彭云丽, 代迎欢, 周旭春

“…【结论】IL-17的动态改变及紧密连接蛋白occludin和ZO-1的减少可能是导致PI-IBS小鼠内脏高敏感 性和粪便含水百分数增高的原因之一，参与了PI-IBS的发生。…”
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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage by Shan Tian, Ruixue Li, Jiao Li, Jinhui Zou

“…Exposure to PS-NPs activated the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway both in the AOM/DSS mouse model and cellular model. …”
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Impact of 17-alpha ethinyl estradiol (EE2) and diethyl phthalate (DEP) exposure on microRNAs expression and their target genes in differentiated SH-SY5Y cells by Agnese Graziosi, Camilla Corrieri, Giulia Sita, Luca Ghelli, Sabrina Angelini, Roberta d’Emmanuele di Villa Bianca, Emma Mitidieri, Raffaella Sorrentino, Patrizia Hrelia, Fabiana Morroni

“…Gene expression analysis revealed the upregulation of EGFR, IGF1R, BTG2, and SH3BP4, implicating these miRNAs in the regulation of the Ras and PI3K/Akt/mTOR pathways. Our findings highlight distinct cellular responses: DEP disrupts PTEN activity, while EE2 enhances phosphorylation within the PI3K/Akt/mTOR pathway, promoting pro-survival and anti-apoptotic signals. …”
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Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…Notably, the use of the JNK inhibitor SP600125, the PI3K inhibitor LY294002, and the ERK1/2 inhibitor U0126 antagonized the protective effects of DHEA, with SP600125 showing the most significant impact on both HVSMCs and HUVECs.ConclusionOur study has identified a novel mechanism underlying the cardioprotective effects of DHEA. …”
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Boundary plasma studies for a spherical tokamak with lithium walls by A. Antony, L. Carbajal, T.D. Rognlien, M.V. Umansky, A. Froese, S. Howard, C. Ribeiro, R. Ivanov, C. Dunlea, C.P. McNally

“…Fusion Energy (2019) The Plasma Injector 3 (PI3) experiment at General Fusion is a non-compressing experiment with solid lithium walls that studies the formation and quasi-steady state operation of a CHI spherical tokamak Carbajal et al. (2023). …”
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Analysis of the Production and Economic Indicators of Broiler Chicken Rearing in 2020–2023: A Case Study of a Polish Farm by Michalina Adaszyńska-Skwirzyńska, Paweł Konieczka, Mateusz Bucław, Danuta Majewska, Arkadiusz Pietruszka, Sławomir Zych, Danuta Szczerbińska

“…In all of the analyzed production cycles, the PI of broiler chicken rearing was above 100, averaging 120.48%, and the average profit per bird was 0.46 EUR. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Real-time, live, fast dynamic screening studies were performed on a dedicated bench top, mouse-sized, planar SPECT system from t=0 to 1 hour postinjection (p.i.), and consequently, tomographic SPECT/CT imaging was performed, for up to 24 hours p.i. …”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…CCG-257081, but not Vem, induced activation of caspase-3 and -7 in resistant cells and increased PARP cleavage and PI staining. CCG-257081 reduced proliferation and activated caspase-3 in YUMMER_R melanoma tumors. …”
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Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice by Chengfen Wang, Yujing Xia, Yuanyuan Zheng, Weiqi Dai, Fan Wang, Kan Chen, Jingjing Li, Sainan Li, Rong Zhu, Jing Yang, Qin Yin, Huawei Zhang, Junshan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

“…The expression of IL-2, IL-6, TNF-α, and IFN-γ was significantly reduced in the NAC-treated groups. NAC activated PI3K/Akt pathway and inhibited the activation of NF-κB. …”
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Therapeutic effects of Pueraria lobata (Willd.) Ohwi root and Hovenia dulcis Thunb. extracts on alcoholic liver disease: Network pharmacology and experimental validation by Zhendong Chen, Yu Yue, Hongyan An, Haisu Yan, Hyeok-Joo Park, Pei Lin

“…In addition, activation of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway was examined to elucidate the mechanisms underlying the effects of the extract. …”
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Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…We found that SSA exposure influenced the expression of genes involved in critical signaling pathways: mTOR, PI3K, Akt, and NF-κB were downregulated, while AMPK was upregulated. …”
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Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain by Wen S. Sheng, Priyanka Chauhan, Shuxian Hu, Sujata Prasad, James R. Lokensgard

“…Infection-induced macrophage activation and T-cell infiltration into the DRG and LSC were observed at 12 wk p.i., but this neuroinflammation was not affected by treatment with any CB2R agonist. …”
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Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged <55 years by Emiel A. M. Janssen, Håvard Søiland, Ivar Skaland, Einar Gudlaugson, Kjell H. Kjellevold, Arne Nysted, Jon-Arne Søreide, Jan P. A. Baak

“…Background: The prognostic value of the PI3K/Akt/mTOR pathway and PTEN in invasive breast cancer (IBC) is controversial. …”
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淀粉样前体蛋白胞内结构域对阿尔茨海默病模型小鼠神经发生和学习记忆的影响 by 蒋梅, 邓栩, 邱子雄, 崔晓军, 付媛

“…生物信息学结果显示，AICD参与调节AD发病进程中神经发生和学习记忆的靶点有1 723个，关键靶点有TP53、CTNNB1、Akt1、EGFR、SRC、EP300、HDAC1、STAT3、HSP90AA1和MAPK1；另外，KEGG通路注释分析发现PI3K-Akt、HIF-1等信号通路在AICD调节神经发生和学习记忆起关键作用。结论表明AICD可以抑制AD模型小鼠海马神经发生进而损害学习记忆能力，这可能与PI3K-Akt和HIF-1等信号通路有关。…”
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