Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Although several forward genetic screens performed in the same context have identified a broad range of resistance genes that poorly overlap, an integrative analysis revealed a much smaller functional diversity of resistance mechanisms, including reactivation of the MAPK pathway, PI3K-AKT pathway, and Hippo pathway, suggesting that a relatively small number of therapeutic strategies might overcome resistance manifested by a large gene set. …”
Get full text

Analysis of Melanin Concentration on Reflective Pulse Oximetry Using Monte Carlo Simulations by Maximilian Reiser, Oliver Amft, Andreas Breidenassel

“…We model a reflective pulse oximeter and analyse the perfusion index (PI), to represent the signal change due varying blood flow during systole and diastole. …”
Get full text

Improvement of the Power System's Transient Stability Using the Unified Power Flow Controller with Fuzzy Logic Technique by Raghad Hameed Ahmed, Ahmed Said Nouri

“…This article discusses the power flow mechanism in a transmission line, which is necessary for understanding the functioning of UPFC in a transmission line and using a standard PI controller with voltage references in the control circuit of both converters. …”
Get full text

DEFINING RISK CURVES IN FEASIBILITY ANALYSES OF URBAN REGENERATION PROJECTS WITH MONTE CARLO METHOD by Nicholas Fiorentini, Diego Mariotti, Massimo Rovai

“…The financial sustainability of the project was then assessed using indicators such as Net Present Value (NPV), Internal Rate of Return (IRR), Payback Period (PP), and Productivity Index (PI). The DCFA confirmed the economic viability of the project. …”
Get full text

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. …”
Get full text

Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors by Gianluigi Zaza, Paola Tomei, Paolo Ria, Simona Granata, Luigino Boschiero, Antonio Lupo

“…Additionally, the inhibition of the crosstalk among mTORC1, mTORC2, and PI3K confers the antineoplastic activities of these drugs. …”
Get full text

Transcriptomics-based investigation of resistance differences to swine fever between large white pigs and min pigs by Jia Li, Deming Ren, Xiangxu Meng, Yiyun He, Lixian Wang, Xihui Sheng, Ligang Wang

“…The results indicated that a greater number of immune-related pathways such as the JAK-STAT and PI3K-AKT signaling were enriched in Min pigs. Furthermore, genes involved in inflammation and antiviral responses, including IL16, IL27, USP18, and DHX58, were upregulated in post-vaccination Min pigs compared to post-vaccination Large White pigs. …”
Get full text

CIMA: A Novel Classification-Integrated Moving Average Model for Smart Lighting Intelligent Control Based on Human Presence by Aji Gautama Putrada, Maman Abdurohman, Doan Perdana, Hilal Hudan Nuha

“…It consists of a PIR sensor, a NodeMCU microcontroller, a Raspberry Pi-based platform, a relay, and LED lighting. With a sampling rate of 10 seconds and a collection period of 7 days, the system achieved 56852 data records. …”
Get full text

Representações sociais da saúde mental de jovens adultos pós-pandemia do COVID-19 // Social representation of mental health of young adults post- pandemic of COVID-19 by Lorena Beathriz Costa Dourado, Valéria Sena Carvalho

“…Foram entrevistados 20 usuários, de 18 a 29 anos, de um CRAS da cidade de Teresina-PI. Os resultados evidenciaram que os participantes compreendem a saúde mental como um estado de bem-estar, em contrapartida, outros entendem a saúde mental como a ausências de problemas psicológicos. …”
Get full text

Mogućnost primjene dinamičkog programiranja u problemu transporta by Milorad Bojanić

“…To je naročito značajno kada se radi o velikom težinskom značenju W i malom težinskom značenju (Pi) predmeta koji su u transportu. Razmatrani model dinamičkog programiranja može se koristiti i u nekinv drugim praktičnim situacijama. …”
Get full text

Alcoolismo e interferências cognitivas nos processos de atenção e percepção. by Regina Maria Fernandes Lopes, Rejane Corrêa Menezes, Marianne Farina, Allana Moraes, Alan Saloum Bastos

“…Se utiliz6 eltest de atenci6n concentrada de Toulouse-Pi8ron paraevaluar 24 usuarios de alcohol (abstinencia de 12) y 12sin alcohol. …”
Get full text

Clinical and Radiological Outcomes of Corrective Surgery on Adult Spinal Deformity Patients: Comparison of Short and Long Fusion by Koichiro Ono, Kazuo Ohmori, Takeshi Hori

“…Improvement of spinal alignment revealed the advantage of long fusion compared to short fusion, in Cobb angle, sagittal vertical axis (SVA), lumbar lordosis (LL), PI-LL C7 plum line (C7PL), and center sacral vertebral line (CSVL). …”
Get full text

Autonomous Quadcopter Image Processing for Simulated Search and Rescue Flights by Budi Hartono, Muhammad Rizki Zuhri, Citra Asti Rosalia, Nofrijal Fauzan

“…If the marker is detected by the image processing system, the Raspberry Pi program will instruct control commands to the Pixhawk flight controller to ensure the quadcopter lands directly on the recognized marker. …”
Get full text

Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…Exercise significantly upregulated phosphoinositide 3 kinase (PI3K) docking site phosphorylation and downregulated the negative IRS1 phosphorylations thereby increasing the glucose transporter (GLUT) expressions and reducing the lactate accumulation. …”
Get full text

The Blockade of IL6 Counterparts the Osmolar Stress-Induced Apoptosis in Human Conjunctival Epithelial Cells by Hee-Jung Ju, Yong-Soo Byun, Jee-Won Mok, Choun-Ki Joo

“…Cell viability/apoptosis assay was performed using Annexin V/Propidium Iodide (PI) and Cell Counting Kit-8 (CCK-8). Western blot was conducted to measure the abundance of apoptotic markers and IL6 related downstream signaling pathway. …”
Get full text

Graphical Smooth Switching Control Method of Four-Switch Buck-Boost Converter in Fuel Cell Systems by Hongwei Feng, Yuanyuan Liu, Chunping Guo, Ye Li, Tai Li

“…In addition, in order to accelerate the response speed during the system mode switching process and solve the problem of sudden duty cycle changes, this paper designs input voltage feedforward functions for each of the four working modes based on the voltage-current dual loop PI control, greatly enhance the controller’s response speed and effectively reducing the output voltage fluctuation during the mode switching process. …”
Get full text

ADDITION OF RICE HUSK NANOCELLULOSE TO THE IMPACT STRENGTH OF RESIN BASE HEAT CURED by Muhammad Aditya Ramadhan Hasran, Dian Noviyanti Agus Imam, Bambang Sunendar

“…Method:  The research sample consisted of six groups, each group consisting of 8 samples selected by simple random. The PI, P2, P3, P4, P5, and K groups were PMMA with 1%, 2%, 3%, 4%, 5% nano cellulose, and without nano cellulose. …”
Get full text

High-Order Engineering Fastest Controller and Its Application in Thermal Power Units by Shangyao Shi, Jun Li, Yijia Huo, Ruiqi Li, Pengyun Chen

“…The empirical findings underscore the EFC’s pronounced superiority over PI, PID, and SOC in regulatory performance enhancements by 122.2%, 88.0%, and 77.3%, respectively, and in mitigating disturbances by 140.0%, 80.9%, and 54.5%, respectively. …”
Get full text

Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model by Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer

“…In addition, we report that the FDA-approved drug Digitoxin, at concentration close to its therapeutic level, decreased the viability of LTSs and downregulated Sox2 independent of the PI3K/AKT pathway. The potential use of LTSs generated without the addition of any external mitogenic stimulation to study the role of specific factor(s) associated with stemness properties is also discussed.…”
Get full text

A renewable integrated multi-area system for LFC incorporating electrical vehicle with SoC estimation by F. Lalhmangaihzuala, Subir Datta, Samuel Lalngaihawma, Taha Selim Ustun, Akhtar Kalam

“…This proposed system is investigated. Conventional PID, PI, and I controllers are used because they are simple, cheap, and easily available. …”
Get full text