Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis by Hoyeon Lee, Sang Woo Cho, Hyo Sun Cha, Kun Tae, Cheol Yong Choi

“…Morusin, a compound extracted from Morus alba, has shown potential in cancer therapy by targeting multiple signaling pathways, including the PI3K/Akt/mTOR, JAK/STAT, MAPK/ERK, and apoptosis pathways. …”
Get full text

Using micro:bit for building distributed sensor networks in robotic systems by Roman Duban, Yurii Yurko

“…The paper uses an experimental approach, examining the use of standard communication protocols to connect micro:bit with external sensors and controllers, such as Raspberry Pi, to build a modular sensor network. Findings. …”
Get full text

Cytotoxic and Apoptotic Effects of Different Extracts of Artemisia turanica Krasch. on K562 and HL-60 Cell Lines by Zahra Tayarani-Najaran, Mahla Sareban, Atefeh Gholami, Seyed Ahmad Emami, Mahdi Mojarrab

“…In this study, we have investigated the cytotoxic effects of n-hexane, CH2Cl2, EtOAc, EtOH, and EtOH/H2O (1 : 1) extracts of A. turanica Krasch. on two human leukemic cancer cell lines (K562 and HL-60) and J774 as normal cells using alamarBlue (resazurin) assay. PI staining of the fragmented DNA and western blot analysis were used to evaluate the possible apoptotic effect of the extract. …”
Get full text

Genomic landscape and comparative analysis of tissue and liquid-based NGS in Taiwanese anaplastic thyroid carcinoma by Chun-Nan Yeh, Shu-Fu Lin, Chia-Ling Wu, Miaw-Jene Liou, I-Wen Chen, Chiao-Ping Chen, Ching-Fu Chang, Qi‑An Wang, Chiao-En Wu

“…Genetic alterations showed highly heterogeneity, including mutations in RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, cell cycle regulation, other receptor tyrosine kinases, DNA damage response, mismatch repair, and chromatin remodeling. …”
Get full text

Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

“…VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in oncology. …”
Get full text

The association of serum phospholipids levels with chronic kidney disease: A systematic review of observational studies by Zahra Shahveghar Asl, Faezeh Ghalichi, Mohadeseh Badpeyma, Zohreh Ghoreishi

“…The studies demonstrated a significant association between serum levels of total phospholipids (TPLs), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidic acid (PA) and plasmalogen with renal diseases. …”
Get full text

Evaluation of Clinical Effectiveness and Subjective Satisfaction of a New Toothbrush for Postsurgical Hygiene Care: A Randomized Split-Mouth Double-Blind Clinical Trial by Marco Montevecchi, Annalisa Moreschi, Maria Rosaria Gatto, Luigi Checchi, Vittorio Checchi

“…Baseline evaluation took place on the day of surgery and follow-ups were performed at days 7, 14, and 30 postoperatively. A more evident PI reduction was recorded for test toothbrush where a regular decrease was observed till day 14; then, this parameter tended to stabilize, remaining however lower than that recorded for the control toothbrush. …”
Get full text

Metabolic profiles and potential antioxidant mechanisms of hawk tea by Sixia Jiang, Hong Zhang, Ya Song, Mingji Xiao, Hao Hu, Shirui Yu, Feng Xie

“…These pathways included the MAPK and PI3K/AKT signaling pathways, which may be closely related to antioxidant activity. …”
Get full text

A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients by Shayma Ghazi, Dilyar Ahmed Baban, Saif Monem Aziz

“…Before and after 14 days, PI, GI, BOP, salivary IL-1β and AST were evaluated. …”
Get full text

Biochemical profile and milk fat/protein in Saanen and Nubian goats by R.O.F. Prado, M.F. Valencia, R.J.A. Hernández, B.J.L. Zepeda, C.A.C. García

“…Milk fat, milk protein, fat/protein ratio, glucose (GLU), cholesterol (COL), non-esterified fatty acids (NEFA), triacylglycerol (TAG), β-hydroxybutyrate (β-HBA), blood urea nitrogen (BUN), albumin (ALB), globulin (GLOB), total protein (PROT-T), calcium ion (Ca2+), inorganic phosphate (Pi), sodium ion (Na+), potassium ion (K+), magnesium ion (Mg2+), and chloride ion (Cl-) was calculated. …”
Get full text

The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets by Peng Wang, Qian Zhang, Liang Tan, Yanan Xu, Xubiao Xie, Yong Zhao

“…The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family. The mTOR signaling pathway is closely involved in a variety of cell biological processes, including cell growth and cell metabolism, by senses and integrates various environmental cues. …”
Get full text

A Modified RBF Neuro-Sliding Mode Control Technique for a Grid Connected PMSG Based Variable Speed Wind Energy Conversion System by Rostand Marc Douanla, Godpromesse Kenné, François Béceau Pelap, Armel Simo Fotso

“…Furthermore, a flexible grid side voltage source converter control structure which can handle both grid connected and standalone modes based on conventional proportional integral (PI) control method is presented. Simulations are done in Matlab/Simulink environment to verify the effectiveness and assess the performance of the proposed controller. …”
Get full text

The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer by Guomin Gu, Chunling Liu, Yan Yang, Yan Zhao, Xiaodan Zhu, Gang Sun

“…A total of 1323 DEGs were predominantly enriched in the PI3K-Akt signalling pathway, cell adhesion molecules, and metabolism of xenobiotics by cytochrome P450. …”
Get full text

Rotor Speed Control of a Direct-Driven Permanent Magnet Synchronous Generator-Based Wind Turbine Using Phase-Lag Compensators to Optimize Wind Power Extraction by Ester Hamatwi, Innocent E. Davidson, Michael N. Gitau

“…The proportional-integral (PI), proportional-derivative (PD), and proportional-integral-derivative (PID) controllers have widely been employed in MPPT studies owing to their simple structure and simple design procedure. …”
Get full text

A Review on the Role of Human Solute Carriers Transporters in Cancer by Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

“…Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. …”
Get full text

PSO-Aided Inverse Design of Silicon Modulator by Zijian Zhu, Yingxuan Zhao, Zhen Sheng, Fuwan Gan

“…As a result, we incorporate the inverse design method with the particle swarm optimization (PSO) algorithm and achieve a G-shaped doping profile for the modulator, exhibiting superior <inline-formula><tex-math notation="LaTeX">$V_{\pi } L$</tex-math></inline-formula> of 0.68 V<inline-formula><tex-math notation="LaTeX">$\cdot$</tex-math></inline-formula>cm and low loss of 9.3 dB/cm. …”
Get full text

An Approach to Fall Detection Using Statistical Distributions of Thermal Signatures Obtained by a Stand-Alone Low-Resolution IR Array Sensor Device by Nishat Tasnim Newaz, Eisuke Hanada

“…The system was implemented using a Raspberry Pi-based stand-alone device that provides a cost-effective solution without the need for additional computational devices. …”
Get full text

Cicer arietinum abscisic acid receptor PYL1 and glycine-rich RNA-binding, abscisic acid-inducible protein-like differential expression under induced draught conditions by Slishchuk Heorhii, Volkova Nataliia, Dilafruz Kholmurodova

“…This study focuses on the differential expression of two key drought- responsive genes: abscisic acid receptor PYL1 and glycine-rich RNA- binding abscisic acid-inducible protein-like in two chickpea genotypes, Desi PI598080 (non-drought-tolerant) and Kabuli Flip07 318C (drought- tolerant), under both control and simulated drought stress conditions. …”
Get full text

Transcriptome analysis of testis in response to silencing of Piwi2 sheds light on spermatogenesis in the mud crab Scylla paramamosain by Tao Wang, Li Lu, Fang Liu, An Liu, Haihui Ye

“…Piwi proteins act in interaction with piRNAs to influence germline development in a variety of organisms. …”
Get full text

Novel fusion protein REA induces robust prime protection against tuberculosis in mice by Sintayehu Kebede Gurmessa, Han-Gyu Choi, Yong Woo Back, Zongyou Jiang, Thuy An Pham, Seunga Choi, Hwa-Jung Kim

“…REA-activated macrophages operated the killing mechanisms of Mycobacterium tuberculosis (MTB), such as phagosomal maturation and phagolysosome fusion, through the (PI3K)–p38 MAPK-Ca2+-NADPH oxidase pathway. Dendritic cells and macrophages activated by REA elicited synergistic anti-mycobacterial responses. …”
Get full text