Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity by Wenlong Liu, Qingxiang Zeng, Yanqiu Chen, Ren Zhong Luo

“…Our results suggested that in an obese state, upregulation of leptin and OPN regulates apoptosis, adhesion, migration, and activation of eosinophils, and this process may be mediated by the PI3K and anti-α4 pathways.…”
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Oral health status in children undergoing chemotherapy at Erbil city: A case control study. by Zahraa Emaad Ahmed, Sazan Sherdl Salim

“…Data on decayed, missing and filled teeth as (DMFT/dmft) scores and simplified plaque index (PI) were collected through and intra-oral examination. …”
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Neural Network-Based Parameter Estimation and Compensation Control for Time-Delay Servo System of Aeroengine by Hongyi Chen, Qiuhong Li, Zhifeng Ye, Shuwei Pang

“…Compared to the existing PI and PI with Smith predictor methods, the ML-NNPC method achieves better control performance in the control of both the SVS and the engine rotor speed system. …”
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Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress by Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng

“…The mechanism is linked with the upregulation of HIF-1α and UCP2, which subsequently activate the PI3K/AKT/Nrf2 signaling pathway.…”
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Inactivation of Different Salmonella enteriditis Phage Types and Safety and Efficacy of Inactivated Products in Chicken by A. Akhtar, M. Hair-Bejo, Elawad A. Hussein, Zunita Zakaria

“…Sampling was conducted on day 14 after inoculation (pi). Eight chickens from each group were separated on day 14 pi for oral challenge with 0.20 mL/chicken (1010 cfu/mL) SE pt 6A and designated CV1C, CV3AC, CV6AC, CV7C, CV35C, and CV0C as control chickens. …”
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Transcatheter closure of multiple ventricular septal ruptures after acute myocardial infarction: a case report highlighting the role of 3D transthoracic echocardiography by Tengku Winda Ardini, Yuke Sarastri, Joy Wulansari Purba, Yasdika Imam Taufik, Suci Asriri, Ali Nafiah Nasution

“…Abstract Background Post-infarct ventricular septal rupture (PI-VSR) is a rare complication of acute myocardial infarction (AMI) but has very serious implications. …”
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YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells by Yu Yan, Qiang Song, Li Yao, Liang Zhao, Hui Cai

“…We also identified that both G13-RhoA and PI3K/Akt signaling pathway were necessary for CM-YAP+ induced activation of YAP. …”
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Pretreatment of Small-for-Size Grafts In Vivo by γ-Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation by Tomohide Hori, Shinji Uemoto, Lindsay B. Walden, Feng Chen, Ann-Marie T. Baine, Toshiyuki Hata, Justin H. Nguyen

“…GABAR regulation appeared to reduce DNA damage via the ATM/H2AX pathway and to promote cell survival via the PI3K/Akt pathway. Conclusions. Pretreatment in vivo by GABAR regulation improves graft damage after SOLT with an SFSG. …”
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Determination of inorganic elements in pine pollen by ICP-MS and safety and health risk assessment by Hao LIU, Haitao GUO, Aixi JI, Shuqi LI, Shaojun YU, Guohua YANG, Zhuoer LIU, Yonggang LIU

“…The results show that pine pollen mainly contains six inorganic elements: Na, Mg, K, Ca, Fe and Zn. The results of Pi show that the pine pollen samples are not contaminated and the level is excellent. …”
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Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia by David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

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Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kuehling, Mirjam Lechner, Hermann Willems, Robert Ringseis, Gerald Reiner

“…For this purpose, the three to five least affected (SINS-low) and most SINS affected (SINS-high) 3d-old piglets, each of three boars, a relatively SINS stable Duroc boar (DU), a relatively stable Pietrain boar (PI+) and a highly susceptible Pietrain boar (PI-) were selected from 27 litters of mixed semen to minimize environmental effects. …”
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H-89和wortmannin对霍乱毒素促进受损视网膜节细胞再生作用的影响

“…【目的】研究蛋白激酶A(PKA)抑制剂H-89和磷酸肌醇3-激酶(PI3-K)特异抑制剂wortmannin对霍乱毒素(CTx)促进受损视网膜节细胞(RGCs)再生的影响,探讨CTx促进受损视网膜节细胞(RGCs)再生的作用机制。…”
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Activity trypsin-like proteinases and intestinal mucosa collagen degradation at gastro-intestinal diseases by О. E. Akbasheva, V. A. Burkovskaya, A. E. Dehand, E. I. Beloborodova, L. A. Akimova, E. L. Naumova, E. A. Kvach

“…Activity of a1-proteinase inhibitor (a1-PI) and a2-macroglobulin (a2-MG) was determined by unified method on of BAEE hydrolysis inhibition. …”
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Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model by Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu

“…These results showed that RIC protected the myocardium from I/R injury by suppressing Rho-kinase and the underlying mechanism may be related to enhancing autophagy via the PI3K/AKT pathway.…”
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Development of Smart Plate Number Recognition System for Fast Cars with Web Application by Olamilekan Shobayo, Ayobami Olajube, Nathan Ohere, Modupe Odusami, Obinna Okoyeigbo

“…Once it was less than the set time, the camera was triggered to capture the plate number and store the image on the Raspberry Pi. The image captured is processed by the Raspberry Pi to extract the numbers on the image. …”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…LF-Exos may inhibit the activity of the NLRP3 inflammasome and activate the PI3K-AKT signaling pathway to exert protective effects on acutely injured hepatocytes and a mouse model of ALF.…”
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Diagnostic Accuracy Of Spectral Doppler Ultrasound In Diagnosis Of Malignant Breast Lesions Taking Histopathology As Gold Standard by Mehwish Tabassum, Rabia Waseem, Manal Niazi, Zainab Riaz, Hamna Shakil, Wajeeha Anam

“…All spectral Doppler indices, including mean peak systolic velocity (PSV), resistive index (RI), and Pulsatility index (PI) were significantly higher in malignant tumours. …”
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Bioinformatics Analysis for Identifying Differentially Expressed MicroRNAs Derived from Plasma Exosomes Associated with Radiotherapy Resistance in Non-Small-Cell Lung Cancer by Lirong Zeng, Guilin Zeng, Zhong Ye

“…Among the 135 identified target genes of miR-92a-3p, 4 were involved in the PI3K-Akt signaling pathway (the downstream pathway of the Ras gene) and 3 in the cAMP signaling pathway (the upstream pathway of the Ras gene). …”
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Clinical and radiographic assessment of the efficacy of platform switched implant and papilla preservation flap design in minimizing crestal bone loss around single tooth implant:... by Tejaswani Kaur, Dilip Naik, Ashita Uppoor, Sangeeta Umesh Nayak, Pragya Atray

“…Material and Methods: In this parallel design randomized controlled trial, a total of 21 patients with single implant site were taken and were randomly divided into three groups—Group A: Platform matched implants with conventional flap design, Group B: Platform switched implants with conventional flap design, and Group C: Platform switched implants with papilla preservation flap design. Clinical parameters (PI, GI, mPI, and mGI index) and radiographic analysis were done to evaluate the outcome of these three techniques. …”
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蛋白酶体抑制剂MG132对Raji细胞凋亡、细胞周期及UBE1基因表达的影响

“…【目的】 探讨蛋白酶体抑制剂MG132对人Burkitt's淋巴瘤Raji细胞凋亡细胞周期及泛素活化酶(UBE1)基因表达的影响【方法】 5 μmol/L的MG132处理Raji细胞24 h,形态学观察细胞生长情况;流式细胞术Annexin V-FITC/PI双染法分析细胞凋亡PI单染法分析细胞周期;荧光定量RT-PCR检测UBE1 基因mRNA表达, Western blot 检测UBE1 蛋白表达【结果】 MG132处理组细胞生长缓慢,死亡及凋亡多见,细胞凋亡率(26.06 ± 1.10)% 较对照组(0.30 ± 0.26)%上升(P < 0.05),G2/M期细胞比率(33.2 ± 1.2)%较对照组(12.5 ± 1.1)%升高(P < 0.05);MG132处理组UBE1 mRNA表达量(0.35 ± 0.05)较对照组(1.00 ± 0.08)下降(P < 0.05),抑制率为65%; UBE1蛋白表达量(0.93 ± 0.07)较对照组(1.62 ± 0.22)下调(P < 0.05),蛋白表达率为(58 ± 6)%【结论】蛋白酶体抑制剂MG132可诱导Raji细胞发生凋亡和G2/M期阻滞,同时抑制UBE1的mRNA和蛋白表达,机制仍待深入研究…”
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